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Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence Zhang, Kun; Lin, Yuhan; Dong, Ling; Niu, Yuting; Peng, Jian; Pannecouque, Christophe; De Clercq, Erik; Tran, Phuong-Thao; Li, Guobo; Zhao, Tiancong; Li, Xudong; Su, Shuo; Wang, Shuai; Chen, Fen-Er Share Save
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Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles Ji, Xiangkai; Jiang, Xiangyi; Gao, Heng; Gao, Zhen; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong Share Save
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Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Meng, Ge; Chen, Fen-Er Share Save
Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability Zhang, Kun; Xing, Tianhao; Ding, Li; Pannecouque, Christophe; De Clercq, Erik; Dettori, Laura; Tramontano, Enzo; Chen, Fen-Er Share Save
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Structure-based design of novel 2,4,5-trisubstituted pyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant regions in NNTRIs binding pocket Zhou, Zhenzhen; Xie, Minghui; Zhuo, Zongji; Wang, Yalin; Zhao, Fabao; Tao, Sining; Liang, Zhening; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Kang, Dongwei; Liu, Xinyong Share Save
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Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses Jiang, Xiangyi; Zalloum, Waleed A.; Gao, Zhen; Dai, Jiaojiao; Ji, Xiangkai; Xie, Minghui; Dong, Guanyu; De Clercq, Erik; Huang, Boshi; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong Share Save
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