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Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases Mallart, Sergio; Ingenito, Raffaele; Magotti, Paola; Bresciani, Alberto; Di Marco, Annalise; Esposito, Simone; Monteagudo, Edith; Caretti, Fulvia; Orsatti, Laura; Santoprete, Alessia; Roversi, Daniela; Tucci, Federica; Veneziano, Maria; Brasseur, Denis; Chenede, Xavier; Corbier, Alain; Gauzy-Lazo, Laurence; Gervat, Vincent; Marguet, Frank; Minoletti, Claire; Pasquier, Olivier; Poirier, Bruno; Azam, Aurelien; Maillere, Bernard; Bianchi, Elisabetta; Janiak, Philip; Duclos, Olivier; Illiano, Stephane Share Save
R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases Poirier, Bruno; Pasquier, Olivier; Chenede, Xavier; Corbier, Alain; Prigent, Philippe; Azam, Aurelien; Bernard, Carine; Guillotel, Michel; Gillot, Florence; Riva, Laurence; Briand, Veronique; Ingenito, Raffaele; Gauzy-Lazo, Laurence; Duclos, Olivier; Philippo, Christophe; Maillere, Bernard; Bianchi, Elisabetta; Mallart, Sergio; Janiak, Philip; Illiano, Stephane Share Save
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor Johns, Douglas G.; Campeau, Louis-Charles; Banka, Puja; Bautmans, An; Bueters, Tjerk; Bianchi, Elisabetta; Branca, Danila; Bulger, Paul G.; Crevecoeur, Inne; Ding, Fa-Xiang; Garbaccio, Robert M.; Guetschow, Erik D.; Guo, Yan; Ha, Sookhee N.; Johnston, Jennifer M.; Josien, Hubert; Kauh, Eunkyung A.; Koeplinger, Kenneth A.; Kuethe, Jeffrey T.; Lai, Eseng; Lanning, Christine L.; Lee, Anita Y. H.; Li, Li; Nair, Anilkumar G.; O'Neill, Edward A.; Stoch, S. Aubrey; Thaisrivongs, David A.; Tucker, Thomas J.; Vachal, Petr; van Dyck, Kristien; Vanhoutte, Frederic P.; Volckaert, Bram; Wolford, Dennis G.; Xu, Andy; Zhao, Tian; Zhou, Dan; Zhou, Susan; Zhu, Xiaohong; Zokian, Hratch J.; Walji, Abbas M.; Wood, Harold B. Share Save
Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species Esposito, Simone; Krick, Alain; Pasquier, Olivier; Bonche, Fabrice; Ingenito, Raffaele; Magotti, Paola; Bianchi, Elisabetta; Monteagudo, Edith; Gallo, Mariana; Cicero, Daniel Oscar; Orsatti, Laura; Veneziano, Maria; Caretti, Fulvia; Mele, Riccardo; Roversi, Daniela; Gennari, Nadia; Brasseur, Denis; Gauzy-Lazo, Laurence; Duclos, Olivier; Mauriac, Christine; Illiano, Stephane; Mallart, Sergio Share Save
Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models Illiano, Stephane; Poirier, Bruno; Minoletti, Claire; Pasquier, Olivier; Riva, Laurence; Chenede, Xavier; Menguy, Isabelle; Guillotel, Michel; Prigent, Philippe; Le Claire, Stephane; Gillot, Florence; Thill, Gilbert; Lo Presti, Francois; Corbier, Alain; Le Bail, Jean-Christophe; Grailhe, Patrick; Monteagudo, Edith; Ingenito, Raffaele; Bianchi, Elisabetta; Philippo, Christophe; Duclos, Olivier; Mallart, Sergio; Bathgate, Ross; Janiak, Philip Share Save
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of and Diabetes Palani, Anandan; Nawrocki, Andrea R.; Orvieto, Federica; Bianchi, Elisabetta; Mandic, Emanuela; Pessi, Antonello; Huang, Chunhui; Deng, Qiaolin; Toussaint, Nathalie; Walsh, Erika; Reddy, Vijay; Ashley, Eric; He, Huaibing; Mumick, Sheena; Hawes, Brian; Marsh, Donald; Erion, Mark; Nargund, Ravi; Carrington, Paul E. Share Save
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity Huang, Chunhui; Palani, Anandan; Yang, Zhiqiang; Deng, Qiaolin; Reddy, Vijay; Nargund, Ravi P.; Lin, Songnian; Altezza, Simona; Bianchi, Elisabetta; Orvieto, Federica; Carrington, Paul Share Save
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease Colarusso, Stefania; Ferrigno, Federica; Ponzi, Simona; Pavone, Francesca; Conte, Immacolata; Abate, Luigi; Beghetto, Elisa; Missineo, Antonino; Amaudrut, Jerome; Bresciani, Alberto; Paonessa, Giacomo; Tomei, Licia; Montalbetti, Christian; Bianchi, Elisabetta; Toniatti, Carlo; Ontoria, Jesus M. M. Share Save
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain Adams, Gregory L.; Pall, Parul S.; Grauer, Steven M.; Zhou, Xiaoping; Ballard, Jeanine E.; Vavrek, Marissa; Kraus, Richard L.; Morissette, Pierre; Li, Nianyu; Colarusso, Stefania; Bianchi, Elisabetta; Palani, Anandan; Klein, Rebecca; John, Christopher T.; Wang, Deping; Tudor, Matthew; Nolting, Andrew F.; Biba, Mirlinda; Nowak, Timothy; Makarov, Alexey A.; Reibarkh, Mikhail; Buevich, Alexei, V; Zhong, Wendy; Regalado, Erik L.; Wang, Xiao; Gao, Qi; Shahripour, Aurash; Zhu, Yuping; de Simone, Daniele; Frattarelli, Tommaso; Pasquini, Nicolo' Maria; Magotti, Paola; Iaccarino, Roberto; Li, Yuxing; Solly, Kelli; Lee, Keun-Joong; Wang, Weixun; Chen, Feifei; Zeng, Haoyu; Wang, Jixin; Regan, Hilary; Amin, Rupesh P.; Regan, Christopher P.; Burgey, Christopher S.; Henze, Darrell A.; Sun, Chengzao; Tellers, David M. Share Save
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor Morissette, Pierre; Li, Nianyu; Ballard, Jeanine E.; Vavrek, Marissa; Adams, Gregory L.; Regan, Chris; Regan, Hillary; Lee, K. J.; Wang, Weixun; Burton, Aimee; Chen, Feifei; Gerenser, Pamela; Li, Yuxing; Kraus, Richard L.; Tellers, David; Palani, Anand; Zhu, Yuping; Sun, Chengzao; Bianchi, Elisabetta; Colarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Pasquini, Nicolo' Maria; Amin, Rupesh P. Share Save
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer Simov, Vladimir; Altman, Michael D.; Bianchi, Elisabetta; DelRizzo, Sonia; DiNunzio, Edward N.; Feng, Guo; Goldenblatt, Peter; Ingenito, Raffaele; Johnson, Scott A.; Mansueto, My Sam; Mayhood, Todd; Mortison, Jonathan D.; Serebrov, Victor; Sondey, Christopher; Sriraman, Venkat; Tucker, Thomas J.; Walji, Abbas; Wan, Hui; Yue, Yingzi; Stoeck, Alexander; DiMauro, Erin F. Share Save
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors Tucker, Thomas J.; Embrey, Mark W.; Alleyne, Candice; Amin, Rupesh P.; Bass, Alan; Bhatt, Bhavana; Bianchi, Elisabetta; Branca, Danila; Bueters, Tjerk; Buist, Nicole; Ha, Sookhee N.; Hafey, Mike; He, Huaibing; Higgins, John; Johns, Douglas G.; Kerekes, Angela D.; Koeplinger, Kenneth A.; Kuethe, Jeffrey T.; Li, Nianyu; Murphy, BethAnn; Orth, Peter; Salowe, Scott; Shahripour, Aurash; Tracy, Rodger; Wang, Weixun; Wu, Chengwei; Xiong, Yusheng; Zokian, Hratch J.; Wood, Harold B.; Walji, Abbas Share Save
Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases Mallart, Sergio; Ingenito, Raffaele; Bianchi, Elisabetta; Bresciani, Alberto; Esposito, Simone; Gallo, Mariana; Magotti, Paola; Monteagudo, Edith; Orsatti, Laura; Roversi, Daniela; Santoprete, Alessia; Tucci, Federica; Veneziano, Maria; Bartsch, Regine; Boehm, Claudius; Brasseur, Denis; Bruneau, Patricia; Corbier, Alain; Froissant, Jacques; Gauzy-Lazo, Laurence; Gervat, Vincent; Marguet, Frank; Menguy, Isabelle; Minoletti, Claire; Nicolas, Marie-Francoise; Pasquier, Olivier; Poirier, Bruno; Raux, Alexandre; Riva, Laurence; Janiak, Philip; Strobel, Hartmut; Duclos, Olivier; Illiano, Stephane Share Save
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design Alleyne, Candice; Amin, Rupesh P.; Bhatt, Bhavana; Bianchi, Elisabetta; Blain, J. Craig; Boyer, Nicolas; Branca, Danila; Embrey, Mark W.; Ha, Sookhee N.; Jette, Kelli; Johns, Douglas G.; Kerekes, Angela D.; Koeplinger, Kenneth A.; LaPlaca, Derek; Li, Nianyu; Murphy, Beth; Orth, Peter; Ricardo, Alonso; Salowe, Scott; Seyb, Kathleen; Shahripour, Aurash; Stringer, Joseph R.; Sun, Yili; Tracy, Rodger; Wu, Chengwei; Xiong, Yusheng; Youm, Hyewon; Zokian, Hratch J.; Tucker, Thomas J. Share Save
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction Colarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Andreini, Matteo; Cerretani, Mauro; Missineo, Antonino; Moretti, Daniele; Tambone, Sara; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Munoz-Sanjuan, Ignacio; Park, Larry; Summa, Vincenzo; Tomei, Licia; Bresciani, Alberto; Dominguez, Celia; Toledo-Sherman, Leticia; Bianchi, Elisabetta Share Save
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction Ontoria, Jesus M.; Biancofiore, Ilaria; Fezzardi, Paola; Ferrigno, Federica; Torrente, Esther; Colarusso, Stefania; Bianchi, Elisabetta; Andreini, Matteo; Patsilinakos, Alexandros; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Summa, Vincenzo; Pacifici, Robert; Munoz-Sanjuan, Ignacio; Park, Larry; Bresciani, Alberto; Dominguez, Celia; Sherman, Leticia Toledo; Harper, Steven Share Save
Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations Brown, Zachary Z.; Mapelli, Claudio; Farasat, Iman; Shoultz, Alycia, V; Johnson, Scott A.; Orvieto, Federica; Santoprete, Alessia; Bianchi, Elisabetta; McCracken, Amy Bittner; Chen, Kuanchang; Zhu, Xiaohong; Demma, Mark J.; Lacey, Brian M.; Canada, Keith A.; Garbaccio, Robert M.; O'Neil, Jennifer; Walji, Abbas Share Save
The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L Buommino, Elisabetta; Carotenuto, Alfonso; Antignano, Ignazio; Bellavita, Rosa; Casciaro, Bruno; Loffredo, Maria Rosa; Merlino, Francesco; Novellino, Ettore; Mangoni, Maria Luisa; Nocera, Francesca Paola; Brancaccio, Diego; Punzi, Pasqualina; Roversi, Daniela; Ingenito, Raffaele; Bianchi, Elisabetta; Grieco, Paolo Share Save
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