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Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model Kiefer, AF; Schütz, C; Englisch, CN; Kolling, D; Speicher, S; Kany, AM; Shafiei, R; Wadood, NA; Aljohmani, A; Wirschem, N; Jumde, RP; Klein, A; Sikandar, A; Park, YM; Krasteva-Christ, G; Yildiz, D; Abdelsamie, AS; Rox, K; Köhnke, J; Müller, R; Bischoff, M; Haupenthal, J; Hirsch, AKH Share Save
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity Abdelsamie, Ahmed S.; Hamed, Mostafa M.; Schuetz, Christian; Roehrig, Teresa; Kany, Andreas M.; Schmelz, Stefan; Blankenfeldt, Wulf; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Synthesis, biological evaluation, and docking studies of pyrazole-linked benzothiazole hybrids as promising anti-TB agents Mohamed-Ezzat, Reham A.; Omar, Mohamed A.; Temirak, Ahmed; Abdelsamie, Ahmed S.; Abdel-Aziz, Marwa M.; Galal, Shadia A.; Elgemeie, Galal H.; Diwani, Hoda I. El; Flanagan, Keith J.; Senge, Mathias Share Save
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections Konstantinovic, Jelena; Kany, Andreas M.; Alhayek, Alaa; Abdelsamie, Ahmed S.; Sikandar, Asfandyar; Voos, Katrin; Yao, Yiwen; Andreas, Anastasia; Shafiei, Roya; Loretz, Brigitta; Schoenauer, Esther; Bals, Robert; Brandstetter, Hans; Hartmann, Rolf W.; Ducho, Christian; Lehr, Claus-Michael; Beisswenger, Christoph; Mueller, Rolf; Rox, Katharina; Haupenthal, Joerg; Hirsch, Anna K. H. Share Save
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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle Hamed, Mostafa M.; Abdelsamie, Ahmed S.; Rox, Katharina; Schuetz, Christian; Kany, Andreas M.; Roehrig, Teresa; Schmelz, Stefan; Blankenfeldt, Wulf; Arce-Rodriguez, Alejandro; Borrero-de Acuna, Jose Manuel; Jahn, Dieter; Rademacher, Jessica; Ringshausen, Felix C.; Cramer, Nina; Tuemmler, Burkhard; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases Alhayek, Alaa; Abdelsamie, Ahmed S.; Schoenauer, Esther; Camberlein, Virgyl; Hutterer, Evelyn; Posselt, Gernot; Serwanja, Jamil; Bloechl, Constantin; Huber, Christian G.; Haupenthal, Jorg; Brandstetter, Hans; Wessler, Silja; Hirsch, Anna K. H. Share Save
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Divergent synthesis and biological evaluation of 2-(trifluoromethyl) pyridines as virulence-attenuating inverse agonists targeting PqsR Schutz, Christian; Hodzic, Amir; Hamed, Mostafa; Abdelsamie, Ahmed S.; Kany, Andreas M.; Bauer, Maximilian; Rohrig, Teresa; Schmelz, Stefan; Scrima, Andrea; Blankenfeldt, Wulf; Empting, Martin Share Save
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer Gargano, Emanuele M.; Mohamed, Abdelrahman; Abdelsamie, Ahmed S.; Mangiatordi, Giuseppe F.; Drzewiecka, Hanna; Jagodzinski, Pawel P.; Mazzini, Arcangela; van Koppen, Chris J.; Laschke, Matthias W.; Nicolotti, Orazio; Carotti, Angelo; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.; Frotscher, Martin Share Save
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms Schuetz, Christian; Ho, Duy-Khiet; Hamed, Mostafa Mohamed; Abdelsamie, Ahmed Saad; Roehrig, Teresa; Herr, Christian; Kany, Andreas Martin; Rox, Katharina; Schmelz, Stefan; Siebenbuerger, Lorenz; Wirth, Marius; Boerger, Carsten; Yahiaoui, Samir; Bals, Robert; Scrima, Andrea; Blankenfeldt, Wulf; Horstmann, Justus Constantin; Christmann, Rebekka; Murgia, Xabier; Koch, Marcus; Berwanger, Aylin; Loretz, Brigitta; Hirsch, Anna Katharina Herta; Hartmann, Rolf Wolfgang; Lehr, Claus-Michael; Empting, Martin Share Save
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies Abdel-Mohsen, Heba T.; El Kerdawy, Ahmed M.; Omar, Mohamed A.; Berrino, Emanuela; Abdelsamie, Ahmed S.; El Diwani, Hoda, I; Supuran, Claudiu T. Share Save
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation Abdelsamie, Ahmed S.; Salah, Mohamed; Siebenbuerger, Lorenz; Hamed, Mostafa M.; Boerger, Carsten; van Koppen, Chris J.; Frotscher, Martin; Hartmann, Rolf W. Share Save
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis Abdelsamie, Ahmed S.; Salah, Mohamed; Siebenbuerger, Lorenz; Merabet, Ahmed; Scheuer, Claudia; Frotscher, Martin; Mueller, Sebastian T.; Zierau, Oliver; Vollmer, Guenter; Menger, Michael D.; Laschke, Matthias W.; van Koppen, Chris J.; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W. Share Save
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Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing Abdelsamie, Ahmed S.; Herath, Steven; Biskupek, Yannik; Boerger, Carsten; Siebenbuerger, Lorenz; Salah, Mohamed; Scheuer, Claudia; Marchais-Oberwinkler, Sandrine; Frotscher, Martin; Pohlemann, Tim; Menger, Michael D.; Hartmann, Rolf W.; Laschke, Matthias W.; van Koppen, Chris J. Share Save
Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy Siebenbuerger, Lorenz; Hernandez-Olmos, Victor; Abdelsamie, Ahmed S.; Frotscher, Martin; van Koppen, Chris J.; Marchais-Oberwinkler, Sandrine; Scheuer, Claudia; Laschke, Matthias W.; Menger, Michael D.; Boerger, Carsten; Hartmann, Rolf W. Share Save
Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs Galal, Shadia A.; Abdelsamie, Ahmed S.; Shouman, Samia A.; Attia, Yasmin M.; Ali, Hamed I.; Tabll, Ashraf; El-Shenawy, Reem; El Abd, Yasmine S.; Ali, Mamdouh M.; Mahmoud, Abeer E.; Abdel-Halim, Abeer H.; Fyiad, Amal A.; Girgis, Adel S.; El-Diwani, Hoda I. Share Save
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