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Discovery of I-1000233, a potent, selective and brain permeable SHP2 allosteric inhibitor Puca, Francesca; Fabbrini, Danilo; Ciammaichella, Alina; Missineo, Antonino; Bisbocci, Monica; Nibbio, Martina; Di Marco, Annalise; Apicella, Claudia; Colaceci, Fabrizio; Sasso, Romina; Natale, Daniela; Scalabri, Francesco; Alli, Cristina; Pucci, Vincenzo; Montalbetti, Christian; Petrocchi, Alessia; Carugo, Alessandro; Toniatti, Carlo Share Save
Discovery of AM E3: A novel α-TLSPR monoclonal antibody for the ADC treatment of CRLF2-rearranged Ph-like B-ALL Dall'Armi, Claudia; Di Biasio, Valentina; Paolini, Chantal; Natale, Daniela; Scalabri, Francesco; Missineo, Antonino; Alaimo, Nadine; Nuzzo, Maurizio; Demartis, Anna; Di Pasquale, Pamela; Benoni, Roberto; Caretti, Fulvia; Beghetto, Elisa; Colaceci, Fabrizio; Sasso, Romina; Pucci, Vincenzo; Carugo, Alessandro; Tomei, Licia; Toniatti, Carlo Share Save
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors Petrocchi, Alessia; Grillo, Alessandro; Ferrante, Luca; Randazzo, Pietro; Prandi, Adolfo; De Matteo, Marilenia; Iaccarino, Costanza; Bisbocci, Monica; Cellucci, Antonella; Alli, Cristina; Nibbio, Martina; Pucci, Vincenzo; Amaudrut, Jerome; Montalbetti, Christian; Toniatti, Carlo; Di Fabio, Romano Share Save
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors Torrente, Esther; Fodale, Valentina; Ciammaichella, Alina; Ferrigno, Federica; Ontoria, Jesus M.; Ponzi, Simona; Rossetti, Ilaria; Sferrazza, Alessio; Amaudrut, Jerome; Missineo, Antonino; Esposito, Simone; Palombo, Simone; Nibbio, Martina; Cerretani, Mauro; Bisbocci, Monica; Cellucci, Antonella; di Marco, Annalise; Alli, Cristina; Pucci, Vincenzo; Toniatti, Carlo; Petrocchi, Alessia Share Save
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes Paonessa, Giacomo; Siciliano, Giulia; Graziani, Rita; Lalli, Cristiana; Cecchetti, Ottavia; Alli, Cristina; La Valle, Roberto; Petrocchi, Alessia; Sferrazza, Alessio; Bisbocci, Monica; Falchi, Mario; Toniatti, Carlo; Bresciani, Alberto; Alano, Pietro Share Save
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease Colarusso, Stefania; Ferrigno, Federica; Ponzi, Simona; Pavone, Francesca; Conte, Immacolata; Abate, Luigi; Beghetto, Elisa; Missineo, Antonino; Amaudrut, Jerome; Bresciani, Alberto; Paonessa, Giacomo; Tomei, Licia; Montalbetti, Christian; Bianchi, Elisabetta; Toniatti, Carlo; Ontoria, Jesus M. M. Share Save
Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair Biferali, Beatrice; Bianconi, Valeria; Perez, Daniel Fernandez; Kronawitter, Sophie Poehle; Marullo, Fabrizia; Maggio, Roberta; Santini, Tiziana; Polverino, Federica; Biagioni, Stefano; Summa, Vincenzo; Toniatti, Carlo; Pasini, Diego; Stricker, Sigmar; Di Fabio, Romano; Chiacchiera, Fulvio; Peruzzi, Giovanna; Mozzetta, Chiara Share Save
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation Sun, Yuting; Bandi, Madhavi; Lofton, Timothy; Smith, Melinda; Bristow, Christopher A.; Carugo, Alessandro; Rogers, Norma; Leonard, Paul; Chang, Qing; Mullinax, Robert; Han, Jing; Shi, Xi; Seth, Sahil; Meyers, Brooke A.; Miller, Meredith; Miao, Lili; Ma, Xiaoyan; Feng, Ningping; Giuliani, Virginia; Do, Mary Geck; Czako, Barbara; Palmer, Wylie S.; Mseeh, Faika; Asara, John M.; Jiang, Yongying; Morlacchi, Pietro; Zhao, Shuping; Peoples, Michael; Tieu, Trang N.; Warmoes, Marc O.; Lorenzi, Philip L.; Muller, Florian L.; DePinho, Ronald A.; Draetta, Giulio F.; Toniatti, Carlo; Jones, Philip; Heffernan, Timothy P.; Marszalek, Joseph R. Share Save
Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors Di Francesco, Maria Emilia; Marszalek, Joseph R.; McAfoos, Timothy; Carroll, Christopher L.; Kang, Zhijun; Liu, Gang; Theroff, Jay P.; Bardenhager, Jennifer P.; Bandi, Madhavi L.; Molina, Jennifer R.; Gera, Sonal; Protopopova, Marina; Sun, Yuting; Do, Mary K. Geck; Feng, Ningping; Gay, Jason P.; Muller, Florian; Konopleva, Marina; Meric-Bernstam, Funda; Toniatti, Carlo; Heffernan, Timothy P.; Draetta, Giulio F.; Jones, Philip Share Save
An inhibitor of oxidative phosphorylation exploits cancer vulnerability Molina, Jennifer R.; Sun, Yuting; Protopopova, Marina; Gera, Sonal; Bandi, Madhavi; Bristow, Christopher; McAfoos, Timothy; Morlacchi, Pietro; Ackroyd, Jeffrey; Agip, Ahmed-Noor A.; Al-Atrash, Gheath; Asara, John; Bardenhagen, Jennifer; Carrillo, Caroline C.; Carroll, Christopher; Chang, Edward; Ciurea, Stefan; Cross, Jason B.; Czako, Barbara; Deem, Angela; Daver, Naval; de Groot, John Frederick; Dong, Jian-Wen; Feng, Ningping; Gao, Guang; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Giuliani, Virginia; Han, Jing; Han, Lina; Henry, Verlene K.; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Khor, Tin; Konoplev, Sergej; Lin, Yu-Hsi; Liu, Gang; Lodi, Alessia; Lofton, Timothy; Ma, Helen; Mahendra, Mikhila; Matre, Polina; Mullinax, Robert; Peoples, Michael; Petrocchi, Alessia; Rodriguez-Canale, Jaime; Serreli, Riccardo; Shi, Thomas; Smith, Melinda; Tabe, Yoko; Theroff, Jay; Tiziani, Stefano; Xu, Quanyun; Zhang, Qi; Muller, Florian; DePinho, Ronald A.; Toniatti, Carlo; Draetta, Giulio F.; Heffernan, Timothy P.; Konopleva, Marina; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination Jiang, Hong; Rivera-Molina, Yisel; Gomez-Manzano, Candelaria; Clise-Dwyer, Karen; Bover, Laura; Vence, Luis M.; Yuan, Ying; Lang, Frederick F.; Toniatti, Carlo; Hossain, Mohammad B.; Fueyo, Juan Share Save
Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models Giuliani, Virginia; Vangamudi, Bhavatarini; Suzuki, Erika; Miller, Meredith; Liu, Chiu-Yi; Carugo, Alessandro; Bristow, Christopher; Gao, Guang; Han, Jing; Sun, Yuting; Feng, Ningping; Chang, Edward; Marszalek, Joseph; Kovacs, Jeffrey; Di Francesco, Maria Emilia; Toniatti, Carlo; Heffernan, Timothy; Jones, Philip; Draetta, Giulio Share Save
IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors Molina, Jennifer; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Cross, Jason; Daver, Naval; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Han, Jing; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Konopleva, Marina; Liu, Gang; Ma, Helen; Matre, Polina; McAfoos, Timothy; Meric-Bernstam, Funda; Morlacchi, Pietro; Muller, Florian; Protopopova, Marina; Smith, Melinda; Sonal, Sonal; Sun, Yuting; Theroff, Jay; Viale, Andrea; Xu, Quanyun; Toniatti, Carlo; Draetta, Giulio; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells Kerros, Celine; Tripathi, Satyendra C.; Zha, Dongxing; Mehrens, Jennifer M.; Sergeeva, Anna; Philips, Anne V.; Qiao, Na; Peters, Haley L.; Katayama, Hiroyuki; Sukhumalchandra, Pariya; Ruisaard, Kathryn E.; Perakis, Alexander A.; John, Lisa S. St.; Lu, Sijie; Mittendorf, Elizabeth A.; Clise-Dwyer, Karen; Herrmann, Amanda C.; Alatrash, Gheath; Toniatti, Carlo; Hanash, Samir M.; Ma, Qing; Molldrem, Jeffrey J. Share Save
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