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The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial Ambery, Philip; Zajac, Grzegorz; Almquist, Joachim; Prothon, Susanne; Astbury, Carol; Brown, Mary N.; Nemes, Szilard; Nsabimana, Joselyne; Edman, Karl; Oberg, Lisa; Lepisto, Matti; Edenro, Goran; Dillmann, Inken; Mitra, Suman; Belfield, Graham; Keen, Christina; Heise, Tim Share Save
AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study van Laar, Jacob M.; Lei, Alejhandra; Safy-Khan, Mary; Almquist, Joachim; Belfield, Graham; Edman, Karl; Oeberg, Lisa; Angermann, Bastian R.; Dillmann, Inken; Berntsson, Pia; Etal, Damla; Dainty, Ian; Astbury, Carol; Belvisi, Maria G.; Nemes, Szilard; Platt, Adam; Prothon, Susanne; Samuelsson, Sara; Svanberg, Petter; Keen, Christina; SEMRA study grp Share Save
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication Postel, Sandra; Wissler, Lisa; Johansson, Carina A.; Gunnarsson, Anders; Gordon, Euan; Collins, Barry; Castaldo, Marie; Koehler, Christian; oeling, David; Johansson, Patrik; Froederberg Roth, Linda; Beinsteiner, Brice; Dainty, Ian; Delaney, Stephen; Klaholz, Bruno P.; Billas, Isabelle M. L.; Edman, Karl Share Save
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction(vol 65, pg 16818, 2022) Pallesen, Jakob S.; Munier, Claire C.; Bosica, Francesco; Andrei, Sebastian A.; Edman, Karl; Gunnarsson, Anders; La Sala, Giuseppina; Putra, Okky Dwichandra; Srdanovic, Sonja; Wilson, Andrew J.; Wissler, Lisa; Ottmann, Christian; Perry, Matthew W. D.; O'Mahony, Gavin Share Save
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction Pallesen, Jakob S.; Munier, Claire C.; Bosica, Francesco; Andrei, Sebastian A.; Edman, Karl; Gunnarsson, Anders; La Sala, Giuseppina; Putra, Okky Dwichandra; Srdanovic, Sonja; Wilson, Andrew J.; Wissler, Lisa; Ottmann, Christian; Perry, Matthew W. D.; O'Mahony, Gavin Share Save
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Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators Munier, Claire C.; De Maria, Leonardo; Edman, Karl; Gunnarsson, Anders; Longo, Marianna; MacKintosh, Carol; Patel, Saleha; Snijder, Arjan; Wissler, Lisa; Brunsveld, Luc; Ottmann, Christian; Perry, Matthew W. D. Share Save
Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor Kohler, C.; Carlstrom, G.; Gunnarsson, A.; Weininger, U.; Tangefjord, S.; Ullah, V; Lepisto, M.; Karlsson, U.; Papavoine, T.; Edman, K.; Akke, M. Share Save
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials Myrback, Tove Hegelund; Prothon, Susanne; Edman, Karl; Leander, Jacob; Hashemi, Mahdi; Dearman, Matthew; Edenro, Goran; Svanberg, Petter; Andersson, Eva-Marie; Almquist, Joachim; Ammala, Carina; Hendrickx, Ramon; Taib, Ziad; Johansson, Kicki A.; Berggren, Anders R.; Keen, Christina M.; Eriksson, Ulf G.; Fuhr, Rainard; Carlsson, Bjorn C. L. Share Save
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection Granberg, Kenneth L.; Yuan, Zhong-Qing; Lindmark, Bo; Edman, Karl; Kajanus, Johan; Hogner, Anders; Malmgren, Marcus; O'Mahony, Gavin; Nordqvist, Anneli; Lindberg, Jan; Tangefjord, Stefan; Kossenjans, Michael; Lofberg, Christian; Branalt, Jonas; Liu, Dongmei; Selmi, Nidhal; Nikitidis, Grigorios; Nordberg, Peter; Hayen, Ahlke; Aagaard, Anna; Hansson, Eva; Hermansson, Majlis; Ivarsson, Ida; Jansson-Lofmark, Rasmus; Karlsson, Ulla; Johansson, Ulrika; William-Olsson, Lena; Hartleib-Geschwindner, Judith; Bamberg, Krister Share Save
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile Ripa, Lena; Edman, Karl; Dearman, Matthew; Edenro, Goran; Hendrickx, Ramon; Ullah, Victoria; Chang, Hui-Fang; Lepisto, Matti; Chapman, Dave; Geschwindner, Stefan; Wissler, Lisa; Svanberg, Petter; Lawitz, Karolina; Malmberg, Jesper; Nikitidis, Antonios; Olsson, Roine I.; Bird, James; Llinas, Antoni; Hegelund-Myrback, Tove; Berger, Markus; Thorne, Philip; Harrison, Richard; Kohler, Christian; Drmota, Tomas Share Save
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases Hemmerling, Martin; Nilsson, Stinabritt; Edman, Karl; Eirefelt, Stefan; Russell, Wayne; Hendrickx, Ramon; Johnsson, Eskil; Mardh, Carina Karrman; Berger, Markus; Rehwinkel, Hartmut; Abrahamsson, Anna; Dahmen, Jan; Eriksson, Anders R.; Gabos, Balint; Henriksson, Krister; Hossain, Nafizal; Ivanova, Svetlana; Jansson, Anne-Helene; Jensen, Tina J.; Jerre, Anders; Johansson, Henrik; Klingstedt, Tomas; Lepisto, Matti; Lindsjo, Martin; Mile, Irene; Nikitidis, Grigorios; Steele, John; Tehler, Ulrika; Wissler, Lisa; Hanson, Thomas Share Save
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Exploring Binding Mechanisms in Nuclear Hormone Receptors by Monte Carlo and X-ray-derived Motions Grebner, Christoph; Lecina, Daniel; Gil, Victor; Ulander, Johan; Hansson, Pia; Dellsen, Anita; Tyrchan, Christian; Edman, Karl; Hogner, Anders; Guallar, Victor Share Save
Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity Nordqvist, Anneli; O'Mahony, Gavin; Friden-Saxin, Maria; Fredenwall, Marlene; Hogner, Anders; Granberg, Kenneth L.; Aagaard, Anna; Backstrom, Stefan; Gunnarsson, Anders; Kaminski, Tim; Xue, Yafeng; Dellsen, Anita; Hansson, Eva; Hansson, Pia; Ivarsson, Ida; Karlsson, Ulla; Bamberg, Krister; Hermansson, Majlis; Georgsson, Jennie; Lindmark, Bo; Edman, Karl Share Save
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Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate Furber, Mark; Tiden, Anna-Karin; Gardiner, Philip; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher; Barber, Simon; Cage, Peter; Sanganee, Hitesh; Austin, Rupert; Chohan, Kamaldeep; Beri, Raj; Thong, Bob; Wallace, Alan; Oreffo, Victor; Hutchinson, Ray; Harper, Steve; Debreczen, Judit; Breed, Jason; Wissler, Lisa; Edman, Karl Share Save
The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger Edman, Karl; Furber, Mark; Hemsley, Paul; Johansson, Cristian; Pairaudeau, Garry; Petersen, Jens; Stocks, Michael; Tervo, Anu; Ward, Alison; Wells, Edward; Wissler, Lisa Share Save
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