Not logged in Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system O'Rourke, Jacqueline G.; Bachmann, Gemma; Mazur, Curt; Zhou, Keming; Platoshyn, Oleksandr; Bravo Hernandez, Mariana; Klein, Stephanie K.; Nguyen, Jonathon; Burel, Sebastien; Hoffmaster, Christine; Zanardi, Thomas; Jafar-nejad, Paymaan; Marsala, Martin; Henry, Scott P.; Swayze, Eric E.; Powers, Berit; Kordasiewicz, Holly B. Share Save
Share Save
Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations Andersson, Patrik; Burel, Sebastien A.; Estrella, Heather; Foy, Jeffrey; Hagedorn, Peter H.; Harper, Tod A.; Henry, Scott P.; Hoflack, Jean-Christophe; Holgersen, Erle M.; Levin, Arthur A.; Morrison, Eliot; Pavlicek, Adam; Penso-Dolfin, Luca; Saxena, Utsav Share Save
Share Save
A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice Jeong, Ji-Seong; Rastogi, Archit; Kim, Tae-Won; Henry, Scott; Hoffmaster, Christine M.; Kim, Sang Yun; Kim, Woojin; Lee, Sun-Young; Park, Jeong-Dong; Wi, In-Su; Yu, Wook-Joon; Lee, Jinsoo Share Save
Share Save
Share Save
Share Save
Share Save
Assessment of the Immunogenicity Potential for Oligonucleotide-Based Drugs Henry, Scott P.; Arfvidsson, Cecilia; Arrington, Josh; Canadi, Jasna; Crowe, Dave; Gupta, Shalini; Lohmann, Sabine; Massonnet, Benoit; Mytych, Daniel; Rogers, Tina; Rogers, Hobart; Stebbins, Chris; Stovold, Craig; Verthelyi, Daniela; Vigil, Adam; Xuan, Chi; Xu, Yuanxin; Yu, Rosie; Klem, Thomas Share Save
Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis Diep, John K.; Yu, Rosie Z.; Viney, Nicholas J.; Schneider, Eugene; Guo, Shuling; Henry, Scott; Monia, Brett; Geary, Richard; Wang, Yanfeng Share Save
Share Save
Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6 Zanardi, Thomas A.; Korbmacher, Birgit; Boone, Laura; Engelhardt, Jeffrey A.; Wang, Yanfeng; Burel, Sebastien; Prill, Bobby; Aghajan, Mariam; Guo, Shuling; Henry, Scott P. Share Save
Sequence-specific 2′-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates Slingsby, Martina H. Lundberg; Vijey, Prakrith; Tsai, I-Ting; Roweth, Harvey; Couldwell, Genevieve; Wilkie, Adrian R.; Gaus, Hans; Goolsby, Jazana M.; Okazaki, Ross; Terkovich, Brooke E.; Semple, John W.; Thon, Jonathan N.; Henry, Scott P.; Narayanan, Padmakumar; Italiano, Joseph E., Jr. Share Save
Immunogenicity Assessment of Inotersen, a 2′-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety Yu, Rosie Z.; Wang, Yanfeng; Norris, Dan A.; Kim, Tae-Won; Narayanan, Padma; Geary, Richard S.; Monia, Brett P.; Henry, Scott P. Share Save
Share Save
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia Narayanan, PadmaKumar; Curtis, Brian R.; Shen, Lijiang; Schneider, Eugene; Tami, Joseph A.; Paz, Suzanne; Burel, Sebastien A.; Tai, Li-Jung; Machemer, Todd; Kwoh, T. Jesse; Xia, Shuting; Shattil, Sanford J.; Witztum, Joseph L.; Engelhardt, Jeffery A.; Henry, Scott P.; Monia, Brett P.; Hughes, Steven G. Share Save
Impurity Qualification Toxicology Study for a 2′-O-Methoxyethyl-Modified Antisense Inhibitor in Mice Kim, Tae-Won; Papagiannis, Chris; Capaldi, Daniel; McPherson, Andrew K.; Mahdi, Farah; Luu, Nhuy; Rodriguez, Andrew A.; Hoffmaster, Christine; Serota, David; Henry, Scott P. Share Save
Share Save
Share Save
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Not logged in.png){kind=icon}