logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Back
M

Michael J. Eck

Dana-Farber Cancer Institute

89H-index
406Paper Count
4.7WCitation Count
Published Papers 118
Publication Date
logo
Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-10-21
err0
PREAI
errMarina C. Primi; Maurício T. Tavares; John M. Hatcher; Hyelim Kang; Tomás A.C. Kresina; Sayan Chakraborty; Emilie Leroy; Anna M. Schmoker; Hyesung Jeon; Ellen L. Weisberg; Taisei Akatsu; James D. Griffin; David A. Scott; Michael J. Eck
errShare
errSave
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
errNature Communications
IF15.7
err2025-10-09
err0
errOAAI
errApril A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
errShare
errSave
Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases
errJournal of Biological Chemistry
IF3.9
err2025-10-08
err0
errOAAI
errEmre Tkacik; Dong Man Jang; Kayla Boxer; Byung Hak Ha; Michael J. Eck
errShare
errSave
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
errNature Communications
IF15.7
err2025-07-31
err0
errOAAI
errApril A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
errShare
errSave
Structure–Activity Relationships of Inactive-Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets
errArchiv der Pharmazie
IF3.6
err2025-07-16
err0
errOAAI
errSurbhi P. Chitnis; Florian Wittlinger; Mareike Möllers; Tyler J. Hartman; Marcel Günther; Michael J. Eck; Stefan A. Laufer; David E. Heppner
errShare
errSave
Brain penetrant allosteric EGFR inhibitors for NSCLC David Scott;
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-12-09
err0
PREAI
errScott, David; Cullis, Courtney; Beyett, Tyler; Feru, Frederic; Gero, Thomas; Gipson, Krista; Gokhalle, Praful; Gray, Nathanael; Heppner, David; Huang, Sampson; Janne, Pasi; Pusalkar, Sandeepraj; Eck, Michael
errShare
errSave
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent Type V Kinase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-12-03
err0
PREAI
errWittlinger, Florian; Chitnis, Surbhi P.; Pham, Calvin D.; Damghani, Tahereh; Patel, Kishan B.; Moellers, Mareike; Schaeffner, Ilse K.; Abidakun, Omobolanle A.; Deng, Matthew Q.; Ogboo, Blessing C.; Rasch, Alexander; Beyett, Tyler S.; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J.; Hershberger, Pamela A.; Scott, David A.; Brandt, Asher L.; Laufer, Stefan A.; Heppner, David E.
errShare
errSave
Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-29
err0
errOAAI
errZhao, Hanchen; Beyett, Tyler S.; Jiang, Jie; Rana, Jaimin K.; Schaeffner, Ilse K.; Santana, Jhasmer; Janne, Pasi A.; Eck, Michael J.
errShare
errSave
Signaling from RAS to RAF: The Molecules and Their Mechanisms
errANNUAL REVIEW OF BIOCHEMISTRY
IF20.5
err2024-08-02
err4
PREAI
errJeon, Hyesung; Tkacik, Emre; Eck, Michael J.
errShare
errSave
A ROLE FOR BRAF FUSION PARTNERS IN ONCOGENIC SIGNALING
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errMisek, Sean; Borgenvik, Anna; Fekade, Ruth; Zhang, Alexander; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung Hyun; Goodale, Amy; Condurat, Alexandra-Larisa; Cordero, Carolina; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadhayay, Pratiti
errShare
errSave
ELUCIDATING THE ROLE OF FGFR1 ALTERATIONS IN PEDIATRIC GLIOMAS
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errApfelbaum, April A.; Morin, Eric; Bahadur, Sher; Sturm, Dominik; Novikov, Dana; DiGiacomo, Jeromy; Cameron, Amy; Rechter, Patrick; Cusick, Margaret M.; Oh, Sehee; Jeon, Hyesung; Vogelzang, Jayne; Jones, Jacquelyn; Bossi, Connor; Quang-De Nguyen; Jones, David T. W.; Eck, Michael J.; Fischer, Eric S.; Ligon, Keith L.; Bandopadhayay, Pratiti
errShare
errSave
BEYOND MAPK SIGNALING - GENOME-SCALE CRISPR/CAS9 SCREENS REVEAL NEW TARGETS FOR TREATMENT OF KIAA1549::BRAF-DRIVEN PEDIATRIC LOW-GRADE GLIOMA
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errBorgenvik, Anna; Misek, Sean; Zhang, Alexander; Fekade, Ruth; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung (Riley) H.; Goodale, Amy; Condurat, Alexandra L.; Cordero, Carolina Ortiz; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadahayay, Pratiti (Mimi)
errShare
errSave
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase
errCHEMMEDCHEM
IF3.4
err2024-05-03
err0
errOAAI
errBeyett, Tyler S.; Rana, Jaimin K.; Schaeffner, Ilse K.; Heppner, David E.; Eck, Michael J.
errShare
errSave
A chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-03-01
err0
PREAI
errLatorre, Pedro; Vitale, Tevis; Ravichandran, Matthew; Gygi, Steven; Kajimura, Shingo; Schmoker, Anna; Jeon, Hyesung; Eck, Michael; Puigserver, Pere
errShare
errSave
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality
errACS CENTRAL SCIENCE
IF10.4
err2024-02-26
err4
errOAAI
errLi, Zhengnian; Jiang, Jie; Ficarro, Scott B.; Beyett, Tyler S.; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J.; Janne, Pasi A.; Marto, Jarrod A.; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S.
errShare
errSave
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2024-02-20
err7
errOAAI
errWittlinger, Florian; Ogboo, Blessing C.; Shevchenko, Ekaterina; Damghani, Tahereh; Pham, Calvin D.; Schaeffner, Ilse K.; Oligny, Brandon T.; Chitnis, Surbhi P.; Beyett, Tyler S.; Rasch, Alexander; Buckley, Brian; Urul, Daniel A.; Shaurova, Tatiana; May, Earl W.; Schaefer, Erik M.; Eck, Michael J.; Hershberger, Pamela A.; Poso, Antti; Laufer, Stefan A.; Heppner, David E.
errShare
errSave
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-02-01
err2
PREAI
errLi, Zhengnian; Lu, Wenchao; Beyett, Tyler S.; Ficarro, Scott B.; Jiang, Jie; Tse, Jason; Kim, Audrey Yong-Ju; Marto, Jarrod A.; Che, Jianwei; Janne, Pasi A.; Eck, Michael J.; Zhang, Tinghu; Gray, Nathanael S.
errShare
errSave
A Constitutive EGFR Kinase Dimer to Study Inhibitor PharmacologyS
errMOLECULAR PHARMACOLOGY
IF3
err2024-02-01
err0
errOAAI
errKim, Justin J.; Schaeffner, Ilse K.; Heppner, David E.; To, Ciric; Janne, Pasi A.; Beyett, Tyler S.; Eck, Michael J.
errShare
errSave
EAI-432: A mutant-selective allosteric EGFR inhibitor for L858R-mutant non-small cell lung cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err2
PREAI
errEck, Michael J.; Scott, David A.; Janne, Pasi; Beyett, Tyler S.; Jiang, Jie; Gokhale, Praful; Gero, Thomas W.
errShare
errSave
Cryo-EM structure of a RAS/RAF recruitment complex (vol 14, 4580, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2023-09-07
err0
errOAAI
errPark, Eunyoung; Rawson, Shaun; Schmoker, Anna; Kim, Byeong-Won; Oh, Sehee; Song, Kangkang; Jeon, Hyesung; Eck, Michael J.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gad Getz
H-index: 248 · Papers: 1.8K
M
Matthew Meyerson
H-index: 223 · Papers: 1.9K
L
Lewis C. Cantley
H-index: 214 · Papers: 1.4K
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
J
Joseph Schlessinger
H-index: 174 · Papers: 719
View more