Not logged in Discovery of I-1000233, a potent, selective and brain permeable SHP2 allosteric inhibitor Puca, Francesca; Fabbrini, Danilo; Ciammaichella, Alina; Missineo, Antonino; Bisbocci, Monica; Nibbio, Martina; Di Marco, Annalise; Apicella, Claudia; Colaceci, Fabrizio; Sasso, Romina; Natale, Daniela; Scalabri, Francesco; Alli, Cristina; Pucci, Vincenzo; Montalbetti, Christian; Petrocchi, Alessia; Carugo, Alessandro; Toniatti, Carlo Share Save
Discovery of AM E3: A novel α-TLSPR monoclonal antibody for the ADC treatment of CRLF2-rearranged Ph-like B-ALL Dall'Armi, Claudia; Di Biasio, Valentina; Paolini, Chantal; Natale, Daniela; Scalabri, Francesco; Missineo, Antonino; Alaimo, Nadine; Nuzzo, Maurizio; Demartis, Anna; Di Pasquale, Pamela; Benoni, Roberto; Caretti, Fulvia; Beghetto, Elisa; Colaceci, Fabrizio; Sasso, Romina; Pucci, Vincenzo; Carugo, Alessandro; Tomei, Licia; Toniatti, Carlo Share Save
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Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors Petrocchi, Alessia; Grillo, Alessandro; Ferrante, Luca; Randazzo, Pietro; Prandi, Adolfo; De Matteo, Marilenia; Iaccarino, Costanza; Bisbocci, Monica; Cellucci, Antonella; Alli, Cristina; Nibbio, Martina; Pucci, Vincenzo; Amaudrut, Jerome; Montalbetti, Christian; Toniatti, Carlo; Di Fabio, Romano Share Save
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors Torrente, Esther; Fodale, Valentina; Ciammaichella, Alina; Ferrigno, Federica; Ontoria, Jesus M.; Ponzi, Simona; Rossetti, Ilaria; Sferrazza, Alessio; Amaudrut, Jerome; Missineo, Antonino; Esposito, Simone; Palombo, Simone; Nibbio, Martina; Cerretani, Mauro; Bisbocci, Monica; Cellucci, Antonella; di Marco, Annalise; Alli, Cristina; Pucci, Vincenzo; Toniatti, Carlo; Petrocchi, Alessia Share Save
STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors Perera, Samanthi A.; Kopinja, Johnny E.; Ma, Yanhong; Muise, Eric S.; Laskey, Jason; Chakravarthy, Kalyan; Chen, Yiping; Cui, Long; Presland, Jeremy; Sathe, Manjiri; Javaid, Sarah; Minnihan, Ellen C.; Ferguson, Heidi M.; Piesvaux, Jennifer; Pan, Bo-Sheng; Zhao, Shuxia; Sharma, Sharad K.; Woo, Hyun Chong; Pucci, Vincenzo; Knemeyer, Ian; Cemerski, Saso; Cumming, Jared; Trotter, B. Wesley; Tse, Archie; Khilnani, Anuradha; Ranganath, Sheila; Long, Brian J.; Bennett, David Jonathan; Addona, George H. Share Save
Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells Wang, Yun; Cui, Long; Georgiev, Peter; Singh, Latika; Zheng, Yanyan; Yu, Ying; Grein, Jeff; Zhang, Chunsheng; Muise, Eric S.; Sloman, David L.; Ferguson, Heidi; Yu, Hongshi; Pierre, Cristina St.; Dakle, Pranal J.; Pucci, Vincenzo; Baker, James; Loboda, Andrey; Linn, Doug; Brynczka, Christopher; Wilson, Doug; Haines, Brian B.; Long, Brian; Wnek, Richard; Sadekova, Svetlana; Rosenzweig, Michael; Haidle, Andrew; Han, Yongxin; Ranganath, Sheila H. Share Save
Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia Liu, Ping; Wang, Liping; DuBois, Byron G.; Colandrea, Vincent J.; Liu, Rongqiang; Cai, Jiaqiang; Du, Xiaoxing; Quan, Weiro; Morris, William; Bai, Jianwu; Bishwokarma, Bimjhana; Cheng, Mangeng; Piesvaux, Jennifer; Ray, Kallol; Alpert, Carla; Chiu, Chi-Sung; Zielstorff, Mark; Metzger, Joseph M.; Yang, Liming; Leung, Dennis; Alleyne, Candice; Vincent, Stella H.; Pucci, Vincenzo; Li, Xiaofang; Crespo, Alejandro; Stickens, Dominique; Hale, Jeffrey J.; Ujjainwalla, Feroze; Sinz, Christopher J. Share Save
A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit Kopinja, Johnny; Sevilla, Raquel S.; Levitan, Diane; Dai, David; Vanko, Amy; Spooner, Edward; Ware, Chris; Forget, Robert; Hu, Kun; Kral, Astrid; Spacciapoli, Peter; Kennan, Richard; Jayaraman, Lata; Pucci, Vincenzo; Perera, Samanthi; Zhang, Weisheng; Fischer, Christian; Lam, Michael H. Share Save
The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma Pokorny, Jenny L.; Calligaris, David; Gupta, Shiv K.; Iyekegbe, Dennis O., Jr.; Mueller, Dustin; Bakken, Katrina K.; Carlson, Brett L.; Schroeder, Mark A.; Evans, Debra L.; Lou, Zhenkun; Decker, Paul A.; Eckel-Passow, Jeanette E.; Pucci, Vincenzo; Ma, Bennett; Shumway, Stuart D.; Elmquist, William F.; Agar, Nathalie Y. R.; Sarkaria, Jann N. Share Save
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants (vol 56, pg 4161, 2012) Summa, Vincenzo; Ludmerer, Steven W.; McCauley, John A.; Fandozzi, Christine; Burlein, Christine; Claudio, Giuliano; Coleman, Paul J.; DiMuzio, Jillian M.; Ferrara, Marco; Di Filippo, Marcello; Gates, Adam T.; Graham, Donald J.; Harper, Steven; Hazuda, Daria J.; Huang, Qian; McHale, Carolyn; Monteagudo, Edith; Pucci, Vincenzo; Rowley, Michael; Rudd, Michael T.; Soriano, Aileen; Stahlhut, Mark W.; Vacca, Joseph P.; Olsen, David B.; Liverton, Nigel J.; Carroll, Steven S. Share Save
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase Di Francesco, M. Emilia; Avolio, Salvatore; Pompei, Marco; Pesci, Silvia; Monteagudo, Edith; Pucci, Vincenzo; Giuliano, Claudio; Fiore, Fabrizio; Rowley, Michael; Summa, Vincenzo Share Save
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants Summa, Vincenzo; Ludmerer, Steven W.; McCauley, John A.; Fandozzi, Christine; Burlein, Christine; Claudio, Giuliano; Coleman, Paul J.; DiMuzio, Jillian M.; Ferrara, Marco; Di Filippo, Marcello; Gates, Adam T.; Graham, Donald J.; Harper, Steven; Hazuda, Darla J.; McHale, Carolyn; Monteagudo, Edith; Pucci, Vincenzo; Rowley, Michael; Rudd, Michael T.; Soriano, Aileen; Stahlhut, Mark W.; Vacca, Joseph P.; Olsen, David B.; Liverton, Nigel J.; Carroll, Steven S. Share Save
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor Harper, Steven; McCauley, John A.; Rudd, Michael T.; Ferrara, Marco; DiFilippo, Marcello; Crescenzi, Benedetta; Koch, Uwe; Petrocchi, Alessia; Holloway, M. Katharine; Butcher, John W.; Romano, Joseph J.; Bush, Kimberly J.; Gilbert, Kevin F.; McIntyre, Charles J.; Nguyen, Kevin T.; Nizi, Emanuela; Carroll, Steven S.; Ludmerer, Steven W.; Burlein, Christine; DiMuzio, Jillian M.; Graham, Donald J.; McHale, Carolyn M.; Stahlhut, Mark W.; Olsen, David B.; Monteagudo, Edith; Cianetti, Simona; Giuliano, Claudio; Pucci, Vincenzo; Trainor, Nicole; Fandozzi, Christine M.; Rowley, Michael; Coleman, Paul J.; Vacca, Joseph P.; Summa, Vincenzo; Liverton, Nigel J. Share Save
Enhancement of intestinal absorption of 2-methyl cytidine prodrugs Cianetti, Simona; Cooper, Vincent Brett; Attenni, Barbara; Pucci, Vincenzo; Fiore, Fabrizio; Giuliano, Claudio; Laufer, Ralph; Gardelli, Cristina; Monteagudo, Edith; Narjes, Frank; Pearce, Gareth Edward; Rowley, Michael Share Save
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Cyclic phosphoramidates as prodrugs of 2′-C-methylcytidine Meppen, Malte; Pacini, Barbara; Bazzo, Renzo; Koch, Uwe; Leone, Joseph F.; Koeplinger, Kenneth A.; Rowley, Michael; Altamura, Sergio; Di Marco, Annalise; Fiore, Fabrizio; Giuliano, Claudio; Gonzalez-Paz, Odalys; Laufer, Ralph; Pucci, Vincenzo; Narjes, Frank; Gardelli, Cristina Share Save
Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection Gardelli, Cristina; Attenni, Barbara; Donghi, Monica; Meppen, Malte; Pacini, Barbara; Harper, Steven; Di Marco, Annalise; Fiore, Fabrizio; Giuliano, Claudio; Pucci, Vincenzo; Laufer, Ralph; Gennari, Nadia; Marcucci, Isabella; Leone, Joseph F.; Olsen, David B.; MacCoss, Malcolm; Rowley, Michael; Narjes, Frank Share Save
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