Not logged in Mapping the landscape of genetic dependencies in chordoma Sharifnia, Tanaz; Wawer, Mathias J.; Goodale, Amy; Lee, Yenarae; Kazachkova, Mariya; Dempster, Joshua M.; Muller, Sandrine; Levy, Joan; Freed, Daniel M.; Sommer, Josh; Kalfon, Jeremie; Vazquez, Francisca; Hahn, William C.; Root, David E.; Clemons, Paul A.; Schreiber, Stuart L. Share Save
Reference compounds for characterizing cellular injury in high-content cellular morphology assays Dahlin, Jayme L.; Hua, Bruce K.; Zucconi, Beth E.; Nelson, Shawn D.; Singh, Shantanu; Carpenter, Anne E.; Shrimp, Jonathan H.; Lima-Fernandes, Evelyne; Wawer, Mathias J.; Chung, Lawrence P. W.; Agrawal, Ayushi; O'Reilly, Mary; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena; Li, Fengling; Lak, Parnian; Cuellar, Matthew; Cole, Philip A.; Meier, Jordan L.; Thomas, Tim; Baell, Jonathan B.; Brown, Peter J.; Walters, Michael A.; Clemons, Paul A.; Schreiber, Stuart L.; Wagner, Bridget K. Share Save
Chromatin-state barriers enforce an irreversible mammalian cell fate decision Blanco, M. Andres; Sykes, David B.; Gu, Lei; Wu, Mengjun; Petroni, Ricardo; Karnik, Rahul; Wawer, Mathias; Rico, Joshua; Li, Haitao; Jacobus, William D.; Jambhekar, Ashwini; Cheloufi, Sihem; Meissner, Alexander; Hochedlinger, Konrad; Scadden, David T.; Shi, Yang Share Save
Application of MCAT questions as a testing tool and evaluation metric for knowledge graph-based reasoning systems Fecho, Karamarie; Balhoff, James; Bizon, Chris; Byrd, William E.; Hang, Sui; Koslicki, David; Rensi, Stefano E.; Schmitt, Patrick L.; Wawer, Mathias J.; Williams, Mark; Ahalt, Stanley C. Share Save
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity Sheppard, Hadley E.; Dall'Agnese, Alessandra; Park, Woojun D.; Shamim, M. Hamza; Dubrulle, Julien; Johnson, Hannah L.; Stossi, Fabio; Cogswell, Patricia; Sommer, Josh; Levy, Joan; Sharifnia, Tanaz; Wawer, Mathias J.; Nabet, Behnam; Gray, Nathanael S.; Clemons, Paul A.; Schreiber, Stuart L.; Workman, Paul; Young, Richard A.; Lin, Charles Y. Share Save
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Small-molecule targeting of brachyury transcription factor addiction in chordoma Sharifnia, Tanaz; Wawer, Mathias J.; Chen, Ting; Huang, Qing-Yuan; Weir, Barbara A.; Sizemore, Ann; Lawlor, Matthew A.; Goodale, Amy; Cowley, Glenn S.; Vazquez, Francisca; Ott, Christopher J.; Francis, Joshua M.; Sassi, Slim; Cogswell, Patricia; Sheppard, Hadley E.; Zhang, Tinghu; Gray, Nathanael S.; Clarke, Paul A.; Blagg, Julian; Workman, Paul; Sommer, Josh; Hornicek, Francis; Root, David E.; Hahn, William C.; Bradner, James E.; Wong, Kwok K.; Clemons, Paul A.; Lin, Charles Y.; Kotz, Joanne D.; Schreiber, Stuart L. Share Save
Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds Melillo, Bruno; Zoller, Jochen; Hua, Bruce K.; Verho, Oscar; Borghs, Jannik C.; Nelson, Shawn D., Jr.; Maetani, Micah; Wawer, Mathias J.; Clemons, Paul A.; Schreiber, Stuart L. Share Save
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer Viswanathan, Srinivas R.; Nogueira, Marina F.; Buss, Colin G.; Krill-Burger, John M.; Wawer, Mathias J.; Malolepsza, Edyta; Berger, Ashton C.; Choi, Peter S.; Shih, Juliann; Taylor, Alison M.; Tanenbaum, Benjamin; Pedamallu, Chandra Sekhar; Cherniack, Andrew D.; Tamayo, Pablo; Strathdee, Craig A.; Lage, Kasper; Carr, Steven A.; Schenone, Monica; Bhatia, Sangeeta N.; Vazquez, Francisca; Tsherniak, Aviad; Hahn, William C.; Meyerson, Matthew Share Save
Data-analysis strategies for image-based cell profiling Caicedo, Juan C.; Cooper, Sam; Heigwer, Florian; Warchal, Scott; Qiu, Peng; Molnar, Csaba; Vasilevich, Aliaksei S.; Barry, Joseph D.; Bansal, Harmanjit Singh; Kraus, Oren; Wawer, Mathias; Paavolainen, Lassi; Herrmann, Markus D.; Rohban, Mohammad; Hung, Jane; Hennig, Holger; Concannon, John; Smith, Ian; Clemons, Paul A.; Singh, Shantanu; Rees, Paul; Horvath, Peter; Linington, Roger G.; Carpenter, Anne E. Share Save
Inhibitors of the enzyme dihydroorotate dehydrogenase, overcome the differentiation blockade in acute myeloid leukemia Janzer, Andreas; Sykes, David; Gradl, Stefan; Ferrara, Steven; Christian, Sven; Merz, Claudia; Seidel, Henrik; Bernthaler, Andreas; Lesche, Ralf; Wawer, Mathias; Scadden, David T. Share Save
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay Bray, Mark-Anthony; Gustafsdottir, Sigrun M.; Rohban, Mohammad H.; Singh, Shantanu; Ljosa, Vebjorn; Sokolnicki, Katherine L.; Bittker, Joshua A.; Bodycombe, Nicole E.; Dancik, Vlado; Hasaka, Thomas P.; Hon, Cindy S.; Kemp, Melissa M.; Li, Kejie; Walpita, Deepika; Wawer, Mathias J.; Golub, Todd R.; Schreiber, Stuart L.; Clemons, Paul A.; Shamji, Alykhan F.; Carpenter, Anne E. Share Save
Real-Time Biological Annotation of Synthetic Compounds Gerry, Christopher J.; Hua, Bruce K.; Waver, Mathias J.; Knowles, Jonathan P.; Nelson, Shawn D., Jr.; Verho, Oscar; Dandapani, Sivaraman; Wagner, Bridget K.; Clemons, Paul A.; Booker-Milburn, Kevin I.; Boskovic, Zarko V.; Schreiber, Stuart L. Share Save
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset Seashore-Ludlow, Brinton; Rees, Matthew G.; Cheah, Jaime H.; Cokol, Murat; Price, Edmund V.; Coletti, Matthew E.; Jones, Victor; Bodycombe, Nicole E.; Soule, Christian K.; Gould, Joshua; Alexander, Benjamin; Li, Ava; Montgomery, Philip; Wawer, Mathias J.; Kuru, Nurdan; Kotz, Joanne D.; Hon, C. Suk-Yee; Munoz, Benito; Liefeld, Ted; Dancik, Vlado; Bittker, Joshua A.; Palmer, Michelle; Bradner, James E.; Shamji, Alykhan F.; Clemons, Paul A.; Schreiber, Stuart L. Share Save
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling Wawer, Mathias J.; Li, Kejie; Gustafsdottir, Sigrun M.; Ljosa, Vebjorn; Bodycombe, Nicole E.; Marton, Melissa A.; Sokolnicki, Katherine L.; Bray, Mark-Anthony; Kemp, Melissa M.; Winchester, Ellen; Taylor, Bradley; Grant, George B.; Hon, C. Suk-Yee; Duvall, Jeremy R.; Wilson, J. Anthony; Bittker, Joshua A.; Dancik, Vlado; Narayan, Rajiv; Subramanian, Aravind; Winckler, Wendy; Golub, Todd R.; Carpenter, Anne E.; Shamji, Alykhan F.; Schreiber, Stuart L.; Clemons, Paul A. Share Save
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