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B

Bernard Refouvelet

universite marie et louis pasteur
H指数:19
被引数:1,411

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Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer’s Disease

多组分合成靶向调节胆碱酯酶、氧化应激和淀粉样蛋白聚集活性的多靶点喹唑啉类化合物，用于阿尔茨海默症的治疗

Molecules 2025, Vol. 30, Page 3930
IF4.6
2025-09-300
OAAI
Saida Chakhari; José Marco-Contelles; Isabel Iriepa; Maria do Carmo Carreiras; Fakher Chabchoub; Lhassane Ismaili; Bernard Refouvelet
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
ACS CHEMICAL NEUROSCIENCE
IF3.9
2024-08-290
PRE
Malek, Rim; Salat, Kinga; Totoson, Perle; Karcz, Tadeusz; Refouvelet, Bernard; Skrzypczak-Wiercioch, Anna; Maj, Maciej; Simakov, Alexey; Martin, Helene; Siwek, Agata; Szalaj, Natalia; Godyn, Justyna; Panek, Dawid; Wieckowska, Anna; Jozwiak, Krzysztof; Demougeot, Celine; Kiec-Kononowicz, Katarzyna; Chabchoub, Fakher; Iriepa, Isabel; Marco-Contelles, Jose; Ismaili, Lhassane
(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease

(±)-BIGI-3h: 结合胆碱酯酶，单胺氧化酶和糖原合酶激酶3β 抑制作用的Pentatarget定向配体，具有钙通道拮抗作用和抗聚集特性，可用于阿尔茨海默氏病

ACS CHEMICAL NEUROSCIENCE
IF3.9
2021-04-0229
PREAI
Ismaili, Lhassane; Monnin, Julie; Etievant, Adeline; Arribas, Raquel L.; Viejo, Lucia; Refouvelet, Bernard; Soukup, Ondrej; Janockova, Jana; Hepnarova, Vendula; Korabecny, Jan; Kucera, Tomas; Jun, Daniel; Andrys, Rudolf; Musilek, Kamil; Baguet, Aurelie; Garcia-Frutos, Eva M.; De Simone, Angela; Andrisano, Vincenza; Bartolini, Manuela; de Los Rios, Cristobal; Marco-Contelles, Jose; Haffen, Emmanuel
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-10-3190
PREAI
Benchekroun, Mohamed; Romero, Alejandro; Egea, Javier; Leon, Rafael; Michalska, Patrycja; Buendia, Izaskun; Jimeno, Maria Luisa; Jun, Daniel; Janockova, Jana; Sepsova, Vendula; Soukup, Ondrej; Bautista-Aguilera, Oscar M.; Refouvelet, Bernard; Ouari, Olivier; Marco-Contelles, Jose; Ismaili, Lhassane
Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids
CHEMMEDCHEM
IF3.4
2014-12-2377
OAAI
Benchekroun, Mohamed; Bartolini, Manuela; Egea, Javier; Romero, Alejandro; Soriano, Elena; Pudlo, Marc; Luzet, Vincent; Andrisano, Vincenza; Jimeno, Maria-Luisa; Lopez, Manuela G.; Wehle, Sarah; Gharbi, Tijani; Refouvelet, Bernard; de Andres, Lucia; Herrera-Arozamena, Clara; Monti, Barbara; Bolognesi, Maria Laura; Isabel Rodriguez-Franco, Maria; Decker, Michael; Marco-Contelles, Jose; Ismaili, Lhassane

研究方向

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L
Lhassane Ismaïli
H 指数:26论文数:100被引数:1,987
J
José Marco‐Contelles
H 指数:56论文数:483被引数:1.1万
A
Alain Xicluna
H 指数:12论文数:62被引数:465
H
Hélène Martin
H 指数:30论文数:152被引数:2,659
V
Vincent Luzet
H 指数:14论文数:52被引数:659
I
Isabel Iriepa
H 指数:30论文数:139被引数:2,655
I
Irène Pachón-Angona
H 指数:8论文数:14被引数:339
M
Marc Pudlo
H 指数:17论文数:44被引数:965
Y
Yves Jacquot
H 指数:23论文数:105被引数:1,585
M
Mohamed Benchekroun
H 指数:15论文数:31被引数:856