W. Griffith Humphreys - Publications, H-index & Citations

W. Griffith Humphreys

university of michigan system

51H指数

174论文数

8.2K被引数

收录论文 49

发表时间

Mechanistic investigation of liver injury induced by BMS-932481, an experimental Γ-secretase modulator

TOXICOLOGICAL SCIENCES

IF4.1

2023-06-01

PREAI

Zhuo, Xiaoliang; Howell, Brett A.; Shen, Hong; Woodhead, Jeffrey L.; Mosure, Kathy; Zhang, Yueping; Scialis, Renato J.; Iyer, Ramaswamy; Sun, Yongnian; Boy, Kenneth M.; Lentz, Kimberley A.; Denton, R. Rex; Soars, Matthew G.; Johnson, Benjamin M.; Humphreys, W. Griffith

Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2021-07-01

PREAI

Werner, Jonathan A.; Davies, Rhian; Wahlstrom, Jan; Dahal, Upendra P.; Jiang, Min; Stauber, Jonathan; David, Benjamin; Siska, William; Thomas, Barbara; Ishida, Katsu; Humphreys, W. Griffith; Lipford, J. Russell; Monticello, Thomas M.

Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX)

DRUG METABOLISM REVIEWS

IF3.8

2020-05-26

OAAI

Russell, Laura E.; Schleiff, Mary Alexandra; Gonzalez, Eric; Bart, Aaron G.; Broccatelli, Fabio; Hartman, Jessica H.; Humphreys, W. Griffith; Lauschke, Volker M.; Martin, Iain; Nwabufo, Chukwunonso; Prasad, Bhagwat; Scott, Emily E.; Segall, Matthew; Takahashi, Ryan; Taub, Mitchell E.; Sodhi, Jasleen K.

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2019-04-13

OAAI

Yee, Sook Wah; Giacomini, Marilyn M.; Shen, Hong; Humphreys, W. Griffith; Horng, Howard; Brian, William; Lai, Yurong; Kroetz, Deanna L.; Giacomini, Kathleen M.

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2019-03-18

PREAI

Billington, Sarah; Salphati, Laurent; Hop, Cornelis E. C. A.; Chu, Xiaoyan; Evers, Raymond; Burdette, Doug; Rowbottom, Christopher; Lai, Yurong; Xiao, Guangqing; Humphreys, W. Griffith; Nguyen, Tot Bui; Prasad, Bhagwat; Unadkat, Jashvant D.

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-01-01

OAAI

Shen, Hong; Holenarsipur, Vinay K.; Mariappan, T. Thanga; Drexler, Dieter M.; Cantone, Joseph L.; Rajanna, Prabhakar; Gautam, Shashyendra Singh; Zhang, Yueping; Gan, Jinping; Shipkova, Petia A.; Marathe, Punit; Humphreys, W. Griffith

Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-01-01

OAAI

Barnett, Shelby; Ogungbenro, Kayode; Menochet, Karelle; Shen, Hong; Humphreys, W. Griffith; Galetin, Aleksandra

Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2018-04-10

OAAI

Gong, Jiachang; Iacono, Lisa; Iyer, Ramaswamy A.; Humphreys, William G.; Zheng, Ming

Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines

ACTA PHARMACEUTICA SINICA B

IF14.6

2018-03-01

OAAI

Gu, Xiaomei; Xiao, Qing; Ruan, Qian; Shu, Yuezhong; Dongre, Ashok; Iyer, Ramaswamy; Humphreys, W. Griffith; Lai, Yurong

Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B-Mediated Drug-Drug Interactions Using Population Pharmacokinetic Modeling and Simulation

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2018-01-17

OAAI

Barnett, Shelby; Ogungbenro, Kayode; Menochet, Karelle; Shen, Hong; Lai, Yurong; Humphreys, W. Griffith; Galetin, Aleksandra

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys

AAPS JOURNAL

IF3.7

2017-10-10

PREAI

Morse, Bridget L.; MacGuire, Jamus G.; Marino, Anthony M.; Zhao, Yue; Fox, Maxine; Zhang, Yueping; Shen, Hong; Humphreys, W. Griffith; Marathe, Punit; Lai, Yurong

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778 CYP2C19多态性对11-羟基类固醇脱氢酶1型抑制剂BMS-823778的代谢和药代动力学的临床意义

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2017-10-04

OAAI

Cheng, Yaofeng; Wang, Lifei; Iacono, Lisa; Zhang, Donglu; Chen, Weiqi; Gong, Jiachang; Humphreys, William Griffith; Gan, Jinping

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-09-01

OAAI

Cheng, Yaofeng; Chen, Shenjue; Freeden, Chris; Chen, Weiqi; Zhang, Yueping; Abraham, Pamela; Nelson, David M.; Humphreys, W. Griffith; Gan, Jinping; Lai, Yurong

Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-02-01

OAAI

Shen, Hong; Li, Wenying; Humphreys, W. Griffith; Lai, Yurong

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2016-12-05

PREAI

Gan, Jinping; Zhang, Haiying; Humphreys, W. Griffith

Tissue distribution and tumor uptake of folate receptor targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

ACTA PHARMACEUTICA SINICA B

IF14.6

2016-09-01

OAAI

Shen, Hong; Wang, Lifei; Chen, Weiqi; Menard, Krista; Hong, Yang; Tian, Yuan; Bonacorsi, Samuel J.; Humphrey, W. Griffith; Lee, Francis Y.; Gan, Jinping

Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2016-09-01

145

OAAI

Lai, Yurong; Mandlekar, Sandhya; Shen, Hong; Holenarsipur, Vinay K.; Langish, Robert; Rajanna, Prabhakar; Murugesan, Senthilkumar; Gaud, Nilesh; Selvam, Sabariya; Date, Onkar; Cheng, Yaofeng; Shipkova, Petia; Dai, Jun; Humphreys, William G.; Marathe, Punit

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2016-05-01

OAAI

Shen, Hong; Dai, Jun; Liu, Tongtong; Cheng, Yaofeng; Chen, Weiqi; Freeden, Chris; Zhang, Yingru; Humphreys, W. Griffith; Marathe, Punit; Lai, Yurong

Label-Free Bottom-Up Proteomic Workflow for Simultaneously Assessing the Target Specificity of Covalent Drug Candidates and Their Off-Target Reactivity to Selected Proteins

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2015-12-29

PREAI

Yang, Yanou; Shu, Yue-Zhong; Humphreys, W. Griffith

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development (vol 80, pg 7019, 2015)

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2015-09-02

OAAI

Shaw, Scott A.; Balasubramanian, Balu; Bonacorsi, Samuel; Cortes, Janet Caceres; Cao, Kevin; Chen, Bang-Chi; Dai, Jun; Decicco, Carl; Goswami, Animesh; Guo, Zhiwei; Hanson, Ronald; Humphreys, W. Griffith; Lam, Patrick Y. S.; Li, Wenying; Mathur, Arvind; Maxwell, Brad D.; Michaudel, Quentin; Peng, Li; Pudzianowski, Andrew; Qiu, Feng; Su, Shun; Sun, Dawn; Tymiak, Adrienne A.; Vokits, Benjamin P.; Wang, Bei; Wexler, Ruth; Wu, Dauh-Rurng; Zhang, Yingru; Zhao, Rulin; Baran, Phil S.

研究方向