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Anthony B. Lagnado

Department of Physiology and Biomedical Engineering
H指数:21
被引数:4,469

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Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline

抑制cyclin D1–CDK6可抑制衰老相关炎症基因表达和年龄相关功能下降

Nature Aging
IF19.4
2026-08-200
PRE
Adarsh Rajesh; Aaron P. Havas; Rouven Arnold; Kathryn Lande; Xue Lei; Kelly Yichen Li; Armin Gandhi; Ana Catarina Franco; Seung-Hwa Woo; Anthony B. Lagnado; Angela Liou; K. Garrett Evensen; Linshan Laux; Maggie Klaers; Jake Kircher; Amirhossein Nayeri Rad; Hiroshi Tanaka; Marcos Garcia Teneche; Michael Alcaraz; Karl N. Miller; Zoe Yao; Sviatlana Zaretski; Sainath Mamde; Qian Yang; Jessica Proulx; Andrew Davis; Laurence Haddadin; Carolina Cano Macip; Brightany Li; Nirmalya Dasgupta; Zong Ming Chua; Cedomir Stamenkovic; Gabriele Guarnaccia; Hideki Tanizawa; Charlene Miciano; Elizabeth Smoot; Allen Wang; Rebecca A. Porritt; Alessandra Sacco; Ken-ichi Noma; Jeffrey H. Albrecht; Laura J Niedernhofer; Joao F Passos; April E. Williams; Bing Ren; Kevin Y. Yip; Peter D. Adams
Mitochondrial metabolism and epigenetic crosstalk drive SASP

线粒体代谢与表观遗传学串扰驱动SASP

Nature
IF48.5
2026-07-290
OA
Hélène Martini; Jodie Birch; Francisco D. M. Marques; Stella Victorelli; Anthony B. Lagnado; Nicholas Pirius; Ana Catarina Franco; Gung Lee; Yeaeun Han; Jennifer L. Rowsey; Wazim Mohammed Ismail; Amelia Mazzone; Tianna M. Espe; Taro Hitosugi; Ya Li; Alexander M. Washington; Aaron Havas; Rabi Murad; Xue Lei; Rebecca A. Porritt; Oliver D. K. Maddocks; Jair Machado Espindola-Netto; Dominik Saul; Sundeep Khosla; Diana Jurk; Enis Kostallari; Alexandre Gaspar-Maia; Peter D. Adams; João F. Passos
Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

组蛋白分子伴侣HIRA失活揭示了黑色素细胞前体正常胚胎发育与成体黑色素细胞干细胞维持之间的联系

AGING CELL
IF7.1
2025-05-140
OA
Jaber-Hijazi, F; Arnold, R; Swaminathan, K; Gilroy, K; Wenzel, AT; Lagnado, A; Kirschner, K; Robertson, N; Reid, C; Fullarton, N; Pawlikowski, J; Rai, TS; Baranyk, I; Shi, CH; Yip, KY; Blyth, K; Mesirov, JP; Harris, ML; Passos, JF; Machesky, LM; Adams, PD
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

p53增强DNA修复，并抑制衰老细胞中的细胞质染色质片段和炎症。

NATURE COMMUNICATIONS
IF15.7
2025-03-050
OA
Miller, Karl N.; Li, Brightany; Pierce-Hoffman, Hannah R.; Patel, Shreeya; Lei, Xue; Rajesh, Adarsh; Teneche, Marcos G.; Havas, Aaron P.; Gandhi, Armin; Macip, Carolina Cano; Lyu, Jun; Victorelli, Stella G.; Woo, Seung-Hwa; Lagnado, Anthony B.; Laporta, Michael A.; Liu, Tianhui; Dasgupta, Nirmalya; Li, Sha; Davis, Andrew; Korotkov, Anatoly; Hultenius, Erik; Gao, Zichen; Altman, Yoav; Porritt, Rebecca A.; Garcia, Guillermina; Mogler, Carolin; Seluanov, Andrei; Gorbunova, Vera; Kaech, Susan M.; Tian, Xiao; Dou, Zhixun; Chen, Chongyi; Passos, Joao F.; Adams, Peter D.
Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline

皮肤衰老细胞移植诱导与年龄相关的外周功能障碍和认知功能下降

AGING CELL
IF7.1
2024-10-071
OAAI
Franco, Ana Catarina; Martini, Helene; Victorelli, Stella; Lagnado, Anthony B.; Wyles, Saranya P.; Rowsey, Jennifer L.; Pirius, Nicholas; Woo, Seung-Hwa; Costa, Daniela G.; Chaib, Selim; Tullius, Stefan G.; Tchkonia, Tamar; Kirkland, James L.; Khosla, Sundeep; Jurk, Diana; Cavadas, Claudia; Passos, Joao F.
Spatial mapping of cellular senescence: emerging challenges and opportunities

细胞衰老的空间图谱: 新出现的挑战和机遇

NATURE AGING
IF19.4
2023-07-0344
OA
Gurkar, Aditi U.; Gerencser, Akos A.; Mora, Ana L.; Nelson, Andrew C.; Zhang, Anru R.; Lagnado, Anthony B.; Enninful, Archibald; Benz, Christopher; Furman, David; Beaulieu, Delphine; Jurk, Diana; Thompson, Elizabeth L.; Wu, Fei; Rodriguez, Fernanda; Barthel, Grant; Chen, Hao; Phatnani, Hemali; Heckenbach, Indra; Chuang, Jeffrey H.; Horrell, Jeremy; Petrescu, Joana; Alder, Jonathan K.; Lee, Jun Hee; Niedernhofer, Laura J.; Kumar, Manoj; Konigshoff, Melanie; Bueno, Marta; Sokka, Miiko; Scheibye-Knudsen, Morten; Neretti, Nicola; Eickelberg, Oliver; Adams, Peter D.; Hu, Qianjiang; Zhu, Quan; Porritt, Rebecca A.; Dong, Runze; Peters, Samuel; Victorelli, Stella; Pengo, Thomas; Khaliullin, Timur; Suryadevara, Vidyani; Fu, Xiaonan; Bar-Joseph, Ziv; Ji, Zhicheng; Passos, Joao F.
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

老年小鼠的局部衰老仅部分复制了全身性衰老的益处

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2023-04-1727
OAAI
Farr, Joshua N.; Saul, Dominik; Doolittle, Madison L.; Kaur, Japneet; Rowsey, Jennifer L.; Vos, Stephanie J.; Froemming, Mitchell N.; Lagnado, Anthony B.; Zhu, Yi; Weivoda, Megan; Ikeno, Yuji; Pignolo, Robert J.; Niedernhofer, Laura J.; Robbins, Paul D.; Jurk, Diana; Passos, Joao F.; LeBrasseur, Nathan K.; Tchkonia, Tamara; Kirkland, James L.; Monroe, David G.; Khosla, Sundeep
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

NIH SenNet联盟绘制人类整个生命周期中的衰老细胞以了解生理健康

NATURE AGING
IF19.4
2022-12-2049
OA
Lee, Patty J.; Benz, Christopher C.; Blood, Philip; Boerner, Katy; Campisi, Judith; Chen, Feng; Daldrup-Link, Heike; De Jager, Phil; Ding, Li; Duncan, Francesca E.; Eickelberg, Oliver; Fan, Rong; Finkel, Toren; Furman, David; Garovic, Vesna; Gehlenborg, Nils; Glass, Carolyn; Heckenbach, Indra; Joseph, Ziv-Bar; Katiyar, Pragati; Kim, So-Jin; Koenigshoff, Melanie; Kuchel, George A.; Lee, Haesung; Lee, Jun Hee; Ma, Jian; Ma, Qin; Melov, Simon; Metis, Kay; Mora, Ana L.; Musi, Nicolas; Neretti, Nicola; Passos, Joao F.; Rahman, Irfan; Rivera-Mulia, Juan Carlos; Robson, Paul; Rojas, Mauricio; Roy, Ananda L.; Scheibye-Knudsen, Morten; Schilling, Birgit; Shi, Pixu; Silverstein, Jonathan C.; Suryadevara, Vidyani; Xie, Jichun; Wang, Jinhua; Wong, A. Ian; Niedernhofer, Laura J.; Wang, Siyuan (Steven); Anvari, Hannah; Balough, Julia; Benz, Christopher; Bons, Joanna; Brenerman, Boris; Evans, William; Gerencser, Akos; Gregory, Heather; Hansen, Malene; Justice, Jamie; Kapahi, Pankaj; Murad, Natalia; O'Broin, Amy; Pavone, Mary Ellen; Powell, Mark; Scott, Gary; Shanes, Elisheva; Shankaran, Mahalakshmi; Verdin, Eric; Winer, Daniel; Wu, Fei; Adams, Andrew; Blood, Philip D.; Bueckle, Andreas; Cao-Berg, Ivan; Chen, Hao; Davis, Michael; Filus, Shane; Hao, Yuhan; Hartman, Austin; Hasanaj, Euxhen; Helfer, Jesse; Herr, Bruce, II; Bar Joseph, Ziv; Molla, Gesmira; Mou, Gloria; Puerto, Juan; Quardokus, Ellen M.; Ropelewski, Alexander J.; Ruffalo, Matt; Satija, Rahul; Schwenk, Melissa; Scibek, Robin; Shirey, William; Sibilla, Max; Welling, Joel; Yuan, Zhou; Bonneau, Richard; Christiano, Angela; Izar, Benjamin; Menon, Vilas; Owens, David M.; Phatnani, Hemali; Smith, Colin; Suh, Yousin; Teich, Andrew F.; Bekker, Valerie; Chan, Cliburn; Coutavas, Elias; Hartwig, Matthew G.; Ji, Zhicheng; Nixon, Andrew B.; Dou, Zhixun; Rajagopal, Jayaraj; Slavov, Nikolai; Holmes, David, III; Jurk, Diana; Kirkland, James L.; Lagnado, Anthony; Tchkonia, Tamara; Abraham, Kristin; Dibattista, Amanda; Fridell, Yih-Woei; Howcroft, T. Kevin; Jhappan, Chamelli; Montes, Viviana Perez; Prabhudas, Mercy; Resat, Haluk; Taylor, Veronica; Kumar, Manoj; Cigarroa, Francisco; Cohn, Rachel; Cortes, Tiffany M.; Courtois, Elise; Chuang, Jeffrey; Dave, Monica; Domanskyi, Sergii; Enninga, Elizabeth Ann Lieser; Eryilmaz, Giray Naim; Espinoza, Sara E.; Gelfond, Jon; Kirkland, James; Kuo, Chia-Ling; Lehman, Julia S.; Aguayo-Mazzucato, Cristina; Meves, Alexander; Rani, Meenakshi; Sanders, Shane; Thibodeau, Asa; Tullius, Stefan G.; Ucar, Duygu; White, Brian; Wu, Qian; Xu, Ming; Yamaguchi, Seiji; Assarzadegan, Naziheh; Cho, Chun-Seok; Hwang, Irene; Hwang, Yongha; Xi, Jingyue; Adeyi, Oyedele A.; Aliferis, Constantin F.; Bartolomucci, Alessandro; Dong, Xiao; DuFresne-To, Mickayla J.; Ikramuddin, Sayeed; Johnson, Steve G.; Nelson, Andrew C.; Revelo, Xavier S.; Trevilla-Garcia, Claudia; Sedivy, John M.; Thompson, Elizabeth L.; Robbins, Paul D.; Wang, Jinhua; Aird, Katherine M.; Alder, Jonathan K.; Beaulieu, Delphine; Bueno, Marta; Calyeca, Jazmin; Chamucero-Millaris, Julian A.; Chan, Stephen Y.; Chung, Dongjun; Corbett, Anthony; Gorbunova, Vera; Gowdy, Kymberly M.; Gurkar, Aditi; Horowitz, Jeffrey C.; Hu, Qianjiang; Kaur, Gagandeep; Khaliullin, Timur O.; Lafyatis, Robert; Lanna, Serafina; Li, Dongmei; Ma, Anjun; Morris, Alison; Muthumalage, Thivanka M.; Peters, Victor; Pryhuber, Gloria S.; Reader, Brenda F.; Rosas, Lorena; Sembrat, John C.; Shaikh, Sadiya; Shi, Hangchuan; Stacey, Sean D.; St Croix, Claudette; Wang, Cankun; Wang, Qixin; Watts, Andrew; Gu, Liangcai; Lin, Yiing; Rabinovitch, Peter S.; Sweetwyne, Mariya T.; Artyomov, Maxim N.; Ballentine, Samuel J.; Chheda, Milan G.; Davies, Sherri R.; DiPersio, John F.; Fields, Ryan C.; Fitzpatrick, James A. J.; Fulton, Robert S.; Imai, Shin-ichiro; Jain, Sanjay; Ju, Tao; Kushnir, Vladimir M.; Link, Daniel C.; Ben Major, Michael; Oh, Stephen T.; Rapp, Daniel; Rettig, Michael P.; Stewart, Shelia A.; Veis, Deborah J.; Vij, Kiran R.; Wendl, Michael C.; Wyczalkowski, Matthew A.; Craft, Joseph E.; Enninful, Archibald; Farzad, Negin; Gershkovich, Peter; Halene, Stephanie; Kluger, Yuval; VanOudenhove, Jennifer; Xu, Mina; Yang, Junchen; Yang, Mingyu
Characterization of cellular senescence in aging skeletal muscle
NATURE AGING
IF19.4
2022-07-1585
OA
Zhang, Xu; Habiballa, Leena; Aversa, Zaira; Ng, Yan Er; Sakamoto, Ayumi E. E.; Englund, Davis A. A.; Pearsall, Vesselina M. M.; White, Thomas A. A.; Robinson, Matthew M. M.; Rivas, Donato A. A.; Dasari, Surendra; Hruby, Adam J. J.; Lagnado, Anthony B. B.; Jachim, Sarah K. K.; Granic, Antoneta; Sayer, Avan A. A.; Jurk, Diana; Lanza, Ian R. R.; Khosla, Sundeep; Fielding, Roger A. A.; Nair, K. Sreekumaran; Schafer, Marissa J. J.; Passos, Joao F.; LeBrasseur, Nathan K. K.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner

中性粒细胞以ROS依赖的方式诱导旁分泌端粒功能障碍和衰老

EMBO JOURNAL
IF8.3
2021-03-25125
OA
Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L.; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A.; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D.; Dolan, David; Reeves, Helen L.; Grellscheid, Sushma; Wilson, Colin H.; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L.; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L.; Jurk, Diana; Mann, Derek A.; Passos, Joao F.
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (vol 47, pg 446, 2019)
EBIOMEDICINE
IF10.8
2020-02-0136
OAAI
Hickson, Latonya J.; Prata, Larissa G. P. Langhi; Bobart, Shane A.; Evans, Tamara K.; Giorgadze, Nino; Hashmi, Shahrukh K.; Herrmann, Sandra M.; Jensen, Michael D.; Jia, Qingyi; Jordan, Kyra L.; Kellogg, Todd A.; Khosla, Sundeep; Koerber, Daniel M.; Lagnado, Anthony B.; Lawson, Donna K.; LeBrasseur, Nathan K.; Lerman, Lilach O.; McDonald, Kathleen M.; McKenzie, Travis J.; Passos, Joao F.; Pignolo, Robert J.; Pirtskhalava, Tamar; Saadiq, Ishran M.; Schaefer, Kalli K.; Textor, Stephen C.; Victorelli, Stella G.; Volkman, Tammie L.; Xue, Ailing; Wentworth, Mark A.; Gerdes, Erin O. Wissler; Allison, David B.; Dickinson, Stephanie L.; Ejima, Keisuke; Atkinson, Elizabeth J.; Lenburg, Marc; Zhu, Yi; Tchkonia, Tamara; Kirkland, James L.

研究方向

暂未获取到该数据
J
João F. Passos
H 指数:68论文数:201被引数:2.9万
D
Diana Jurk
H 指数:48论文数:98被引数:2.0万
S
Sundeep Khosla
H 指数:136论文数:754被引数:8.1万
J
James L. Kirkland
H 指数:111论文数:503被引数:5.9万
T
Tamar Tchkonia
H 指数:94论文数:344被引数:4.8万
S
Stella Victorelli
H 指数:20论文数:45被引数:5,081
P
Peter D. Adams
H 指数:78论文数:518被引数:3.3万
N
Nathan K. LeBrasseur
H 指数:78论文数:324被引数:3.3万
J
Jodie Birch
H 指数:17论文数:39被引数:5,677
R
Robert J. Pignolo
H 指数:54论文数:291被引数:1.4万