未登录Lipo-Glc-1,6-P2: A Bioprecursor Prodrug for Phosphomannomutase-2 Congenital Disorder of GlycosylationLipo-Glc-1,6-P2：一种用于糖基化先天性磷甘露糖互变酶-2障碍的生物前体前药
Sodano, Federica; Monticelli, Maria; Mele, Bruno Hay; Rolando, Barbara; Lazzarato, Loretta; De Simone, Angela; Andrisano, Vincenza; Paris, Debora; Rimoli, Maria Grazia; Cubellis, Maria Vittoria; Andreotti, Giuseppina .png)
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收藏分享 收藏 分享 收藏 分享 收藏 分享 收藏 Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic PropertiesPont, Caterina; Sampietro, Anna; Perez-Areales, F. Javier; Cristiano, Nunzia; Albalat, Agusti; Perez, Belen; Bartolini, Manuela; De Simone, Angela; Andrisano, Vincenza; Barenys, Marta; Teixido, Elisabet; Sabate, Raimon; Loza, M. Isabel; Brea, Jose; Munoz-Torrero, Diego 分享 收藏 Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancerGuardigni, Melissa; Greco, Giulia; Poeta, Eleonora; Santini, Alan; Tassinari, Elisa; Bergamini, Christian; Zalambani, Chiara; De Simone, Angela; Andrisano, Vincenza; Uliassi, Elisa; Monti, Barbara; Bolognesi, Maria Laura; Fimognari, Carmela; Milelli, Andrea 分享 收藏 Safety issues in nutraceutical exploitation of Chlorella vulgaris, Arthrospira Platensis and Scenedesmus sp. microalgaeDavani, Lara; Tassinari, Elisa; Chiaberge, Stefano; Siviero, Andrea; Serbolisca, Luca; Tumiatti, Vincenzo; Terenzi, Cristina; De Simone, Angela; Andrisano, Vincenza; Montanari, Serena 分享 收藏 Influence of high-pressure homogenization treatments combined with lysozyme activated packaging on microbiological and technological quality of vegetable smoothie during shelf lifeSiroli, Lorenzo; Glicerina, Virginia; Capelli, Filippo; Patrignani, Francesca; Fiorini, Maurizio; Andrisano, Vincenza; Minelli, Matteo; Gherardi, Matteo; Lanciotti, Rosalba; Colombo, Vittorio; Romani, Santina 分享 收藏 PROTAC-Induced Glycogen Synthase Kinase 3ß Degradation as a Potential Therapeutic Strategy for Alzheimer's DiseasePROTAC诱导的糖原合酶激酶3 ß 降解作为阿尔茨海默病的潜在治疗策略Guardigni, Melissa; Pruccoli, Letizia; Santini, Alan; De Simone, Angela; Bersani, Matteo; Spyrakis, Francesca; Frabetti, Flavia; Uliassi, Elisa; Andrisano, Vincenza; Pagliarani, Barbara; Fernandez-Gomez, Paula; Palomo, Valle; Bolognesi, Maria Laura; Tarozzi, Andrea; Milelli, Andrea 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's diseaseVrabec, Rudolf; Marikova, Jana; Locarek, Miroslav; Korabecny, Jan; Hulcova, Daniela; Hostalkova, Anna; Kunes, Jiri; Chlebek, Jakub; Kucera, Tomas; Hrabinova, Martina; Jun, Daniel; Soukup, Ondrej; Andrisano, Vincenza; Jenco, Jaroslav; Safratova, Marcela; Novakova, Lucie; Opletal, Lubomir; Cahlikova, Lucie 分享 收藏 From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effectsPont, Caterina; Ginex, Tiziana; Grinan-Ferre, Christian; Scheiner, Matthias; Mattellone, Alexia; Martinez, Noemi; Arce, Elsa M.; Soriano-Fernandez, Yolanda; Naldi, Marina; De Simone, Angela; Barenys, Marta; Gomez-Catalan, Jesus; Perez, Belen; Sabate, Raimon; Andrisano, Vincenza; Loza, Maria Isabel; Brea, Jose; Bartolini, Manuela; Laura Bolognesi, Maria; Decker, Michael; Pallas, Merce; Javier Luque, F.; Munoz-Torrero, Diego 分享 收藏 分享 收藏 (±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease(±)-BIGI-3h: 结合胆碱酯酶，单胺氧化酶和糖原合酶激酶3β 抑制作用的Pentatarget定向配体，具有钙通道拮抗作用和抗聚集特性，可用于阿尔茨海默氏病Ismaili, Lhassane; Monnin, Julie; Etievant, Adeline; Arribas, Raquel L.; Viejo, Lucia; Refouvelet, Bernard; Soukup, Ondrej; Janockova, Jana; Hepnarova, Vendula; Korabecny, Jan; Kucera, Tomas; Jun, Daniel; Andrys, Rudolf; Musilek, Kamil; Baguet, Aurelie; Garcia-Frutos, Eva M.; De Simone, Angela; Andrisano, Vincenza; Bartolini, Manuela; de Los Rios, Cristobal; Marco-Contelles, Jose; Haffen, Emmanuel 分享 收藏 Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 MiceViayna, Elisabet; Coquelle, Nicolas; Cieslikiewicz-Bouet, Monika; Cisternas, Pedro; Oliva, Carolina A.; Sanchez-Lopez, Elena; Ettcheto, Miren; Bartolini, Manuela; De Simone, Angela; Ricchini, Mattia; Rendina, Marisa; Pons, Megane; Firuzi, Omidreza; Perez, Belen; Saso, Luciano; Andrisano, Vincenza; Nachon, Florian; Brazzolotto, Xavier; Luisa Garcia, Maria; Camins, Antoni; Silman, Israel; Jean, Ludovic; Inestrosa, Nibaldo C.; Colletier, Jacques-Philippe; Renard, Pierre-Yves; Munoz-Torrero, Diego 分享 收藏 分享 收藏 
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