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Meritxell Canals

University of Nottingham

53H指数
155论文数
9.2K被引数
收录论文 107
发表时间
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The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology多巴胺D3受体与卡利拉赞结合的结构揭示了具有设计药理学特性的部分激动剂的原则
errScience Advances
IF12.5
err2026-08-28
err0
errOAAI
errEliane Hadas Yardeni; Dóra Judit Kiss; Julie Sanchez; Keshet Shavit; Dénes Szepesi Kovács; Attila Egyed; Caleb D. Vogt; Supriya A. Gaitonde; Jacqueline Glenn; Meritxell Canals; Michel Bouvier; Amy Hauck Newman; J. Robert Lane; György M. Keserű; Moran Shalev-Benami
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Quantification of drug rebinding at dopamine D2 receptor-expressing cell membranes with implications for extrapyramidal side effects在多巴胺D2受体表达细胞膜上对药物再结合进行定量，并探讨其对锥体外系副作用的影响
errCommunications Biology
IF5.1
err2026-08-19
err0
errOAAI
errHannah J. Lockington; Meritxell Canals; Jonathan A. Javitch; Stephen J. Briddon; J. Robert Lane
err分享
err收藏
Characterising C-X-C Chemokine Receptor 4 Dynamics in the Cell Membrane Using Fluorescence Fluctuation Spectroscopy
errBiomolecules
IF4.8
err2026-07-30
err0
errOAAI
errNoemi Karsai; Joëlle Goulding; Leigh A. Stoddart; Laura E. Kilpatrick; Stephen J. Hill; Meritxell Canals; Stephen J. Briddon
err分享
err收藏
Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming nitazenes into novel analgesics基于依诺硝唑的双靶点μ阿片-多巴胺D3受体(MOR-D3R)配体：将硝唑类化合物转化为新型镇痛药的新先导化合物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-06-01
err0
PREAI
errJahan, Khorshada; Glatfelter, Grant; Sanchez, Julie; Maitland, Alexander D.; Bonifazi, Alessandro; Saab, Elizabeth; Keegan, Bradley M.; Rais, Rana; Bi, Guo-Hua; Gomez, Juan L.; Michaelides, Michael; Xi, Zheng-Xiong; Lane, J. Robert; Canals, Meritxell; Baumann, Michael H.; Newman, Amy Hauck
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Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletionμ-阿片受体激动剂多样行为效应的差异性抑制及其受体渐进耗竭的影响
errNeuropharmacology
IF4.6
err2026-03-07
err0
errOAAI
errLauren Brown; Cory Langreck; Frances Hough; Mel Nelson; Stephen Briddon; J. Robert Lane; Jonathan A. Javitch; Meritxell Canals
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Membrane Permeability Drives the Extreme Potency of Fentanyl膜通透性驱动芬太尼的极端效力
errJACS Au
IF8.7
err2026-02-18
err0
errOAAI
errJoseph Clayton; George J. Farmer; Jacqueline Glenn; Shailesh N. Mistry; J. Robert Lane; Lei Shi; Lidiya Stavitskaya; Meritxell Canals; Jana Shen
err分享
err收藏
Targeted inhibition of mu-opioid receptors in neuronal subpopulations by membrane-tethered Naloxo-DART antagonists通过膜锚定Naloxo-DART拮抗剂靶向抑制神经元亚群中的μ-阿片受体
errCell Chemical Biology
IF7.2
err2025-12-03
err0
errOAAI
errJ. Sanchez; A. Bonifazi; S. Groom; M.O. Sambrook; G.A. Camacho-Hernandez; E.J. Kuijer; S. Karimi; K.U. Therese; M. Hauge Pedersen; C. Rauffenbart; M. Canals; A.H. Newman; C.P. Bailey; J.A. Javitch; J.R. Lane
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Design, Synthesis, and Characterization of Novel, Subtype-Selective Fluorescent Antagonists Targeting the Nociceptin/Orphanin FQ Opioid Peptide Receptor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errFarmer, George J.; Sanchez, Julie; Millns, Annabell; Antony, Tamzin; Canals, Meritxell; Lane, J. Robert; Mistry, Shailesh N.
err分享
err收藏
Mu Opioid Receptor Activation is Required for NMDA Receptor Antagonist Effects on Stress-induced Maladaptive Behaviorμ阿片受体激活是NMDA受体拮抗剂对压力诱导的不良行为效应所必需的。
errBiological Psychiatry
IF9
err2025-07-07
err0
errOAAI
errCory B. Langreck; Briana Chen; Victor M. Luna; Mel Nelson; Gergely Turi; Rob Hill; Gilles Rubinstenn; Meritxell Canals; J. Robert Lane; Christine A. Denny; Jonathan A. Javitch
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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor鉴定多巴胺D2受体正位别构调节剂的脂质暴露外旋结合位点
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-05-15
err0
PREAI
errLim, Herman D.; Bartuzi, Damian; Keen, Alastair C.; Rauffenbart, Caroline; Glenn, Jacqueline; Charlton, Steven J.; Lovera, Silvia; Sands, Zara A.; Ates, Ali; Wood, Martyn; Canals, Meritxell; Javitch, Jonathan A.; Carlsson, Jens; Lane, J. Robert
err分享
err收藏
GRK5 regulates endocytosis of FPR2 independent of β-arrestins
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
errOAAI
errJack, Christine E.; Cope, Emily M.; Lemel, Laura; Canals, Meritxell; Drube, Julia; Hoffmann, Carsten; Inoue, Asuka; Hislop, James N.; Thompson, Dawn
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Activated microglia secretome and proinflammatory cytokines increase neuronal mu-opioid receptor signalling and expression
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-12-01
err0
errOAAI
errCuitavi, Javier; Duart-Abadia, Pere; Sanchez, Julie; Sanchez-Lopez, Christian M.; Lorente, Jesus D.; Marcilla, Antonio; Farinas, Isabel; Canals, Meritxell; Hipolito, Lucia
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Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-08-02
err3
errOAAI
errUnderwood, Owen; Fritzwanker, Sebastian; Glenn, Jaqueline; Blum, Nina Kathleen; Batista-Gondin, Arisbel; Drube, Julia; Hoffmann, Carsten; Briddon, Stephen J.; Schulz, Stefan; Canals, Meritxell
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Arrestin-centred interactions at the membrane and their conformational determinants
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2024-03-13
err3
errOAAI
errUnderwood, Owen; Haider, Raphael Silvanus; Sanchez, Julie; Canals, Meritxell
err分享
err收藏
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-02-12
err5
PREAI
errTsai, Meng-Hua M.; Chen, Li; Baumann, Michael H.; Canals, Meritxell; Javitch, Jonathan A.; Lane, J. Robert; Shi, Lei
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Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans
errCHEMICAL COMMUNICATIONS
IF4.2
err2024-01-01
err0
errOAAI
errMoore, Jonathan C.; Modell, Louis; Glenn, Jacqueline R.; Jones, Kieran D.; Argent, Stephen P.; Lane, J. Robert; Canals, Meritxell; Lam, Hon Wai
err分享
err收藏
Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3)
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2023-12-08
err3
errOAAI
errDekkers, Sebastian; Comez, Dehan; Karsai, Noemi; Arimont-Segura, Marta; Canals, Meritxell; Caspar, Birgit; de Graaf, Chris; Kilpatrick, Laura E.; Leurs, Rob; Kellam, Barrie; Hill, Stephen J.; Briddon, Stephen J.; Stocks, Michael J.
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Differential interaction patterns of opioid analgesics with μ opioid receptors correlate with ligand-specific voltage sensitivity
errELIFE
IF0
err2023-11-20
err6
errOAAI
errKirchhofer, Sina B.; Lim, Victor Jun Yu; Ernst, Sebastian; Karsai, Noemi; Ruland, Julia G.; Canals, Meritxell; Kolb, Peter; Buenemann, Moritz
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err收藏
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice评估新型和经典阿片类药物诱导小鼠呼吸抑制的潜力
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2023-08-22
err6
errOAAI
errHill, Rob; Sanchez, Julie; Lemel, Laura; Antonijevic, Mirjana; Hosking, Yselkla; Mistry, Shailesh N.; Kruegel, Andrew C.; Javitch, Jonathan A.; Lane, J. Robert; Canals, Meritxell
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Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics双靶点多巴胺D3 (D3R) 和 μ-阿片 (MOR) 受体配体作为潜在更安全的镇痛药的药理和理化性质优化
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-19
err6
errOAAI
errBonifazi, Alessandro; Saab, Elizabeth; Sanchez, Julie; Nazarova, Antonina L.; Zaidi, Saheem A.; Jahan, Khorshada; Katritch, Vsevolod; Canals, Meritxell; Lane, J. Robert; Newman, Amy Hauck
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