Lorente-Macias, Alvaro

University of Edinburgh

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收录论文 12

发表时间

Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth 发现一种高效且选择性强的mTOR抑制剂，可强烈抑制胶质母细胞瘤细胞生长

Journal of Medicinal Chemistry

IF6.8

2026-04-01

PREAI

Lorente-Macias, Alvaro; Mok, Jonathon; Dawson, John C.; Juan-Albuquerque, Ana; Carragher, Neil O.; Frame, Margaret C.; Unciti-Broceta, Asier

Exploring Trisubstituted adenine derivatives as adenosine A1 receptor ligands with antagonist activity: Synthesis, biological evaluation and molecular modelling 探索三取代腺嘌呤衍生物作为具有拮抗剂活性的腺苷A1受体配体的研究：合成、生物评价与分子模拟

BIOORGANIC CHEMISTRY

IF4.7

2025-06-01

PREAI

Cordoba-Gomez, Laura B.; Lorente-Macias, Alvaro; Loza, Maria Isabel; Brea, Jose; Martinez, Anton Leandro; Mok, Jonathon; King, Ben; Franco-Montalban, Francisco; Garcia, Antonio Gonzalez; Guardia-Monteagudo, Juan Jose; Matos, Maria J.; Unciti-Broceta, Asier; Diaz-Mochon, Juan Jose; de Las Infantas, Maria Jose Pineda

Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC MEDICINAL CHEMISTRY

IF3.6

2025-01-01

OAAI

Ayala-Aguilera, Cecilia C.; Ge, Yang; Lorente-Macias, Alvaro; Jones, Benjamin N.; Adam, Catherine; Carragher, Neil O.; Unciti-Broceta, Asier

Degron tagging for rapid protein degradation in mice

DISEASE MODELS & MECHANISMS

IF3.3

2024-04-26

OAAI

Herna, Brianda A.; Taylor, Gillian; Lorente-Macias, Alvaro; Wood, Andrew J.

Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus 开源抗生素: 简单的二芳基咪唑对耐甲氧西林金黄色葡萄球菌有效

ACS INFECTIOUS DISEASES

IF3.8

2023-11-22

OAAI

Klug, Dana M.; Tse, Edwin G.; Silva, Daniel G.; Cao, Yafeng; Charman, Susan A.; Chauhan, Jyoti; Crighton, Elly; Dichiara, Maria; Drake, Chris; Drewry, David; da Silva Emery, Flavio; Ferrins, Lori; Graves, Lee; Hopkins, Emily; Kresina, Thomas A. C.; Lorente-Macias, Alvaro; Perry, Benjamin; Phipps, Richard; Quiroga, Bruno; Quotadamo, Antonio; Sabatino, Giada N.; Sama, Anthony; Schatzlein, Andreas; Simpson, Quillon J.; Steele, Jonathan; Shanu-Wilson, Julia; Sjo, Peter; Stapleton, Paul; Swain, Christopher J.; Vaideanu, Alexandra; Xie, Huanxu; Zuercher, William; Todd, Matthew H.

Discovery of senolytics using machine learning 使用机器学习发现senolyics

NATURE COMMUNICATIONS

IF15.7

2023-06-10

OAAI

Smer-Barreto, Vanessa; Quintanilla, Andrea; Elliott, Richard J. R.; Dawson, John C.; Sun, Jiugeng; Campa, Victor M.; Lorente-Macias, Alvaro; Unciti-Broceta, Asier; Carragher, Neil O.; Acosta, Juan Carlos; Oyarzun, Diego A.

Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-01

OAAI

Baillache, Daniel J.; Valero, Teresa; Lorente-Macias, Alvaro; Bennett, David Jonathan; Elliott, Richard J. R.; Carragher, Neil O.; Unciti-Broceta, Asier

Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-08

156

OAAI

Ayala-Aguilera, Cecilia C.; Valero, Teresa; Lorente-Macias, Alvaro; Baillache, Daniel J.; Croke, Stephen; Unciti-Broceta, Asier

Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi

PHARMACEUTICALS

IF4.8

2021-07-01

OAAI

Martinez-Peinado, Nieves; Lorente-Macias, Alvaro; Garcia-Salguero, Alejandro; Cortes-Serra, Nuria; Fenollar-Collado, Angel; Ros-Lucas, Albert; Gascon, Joaquim; Pinazo, Maria-Jesus; Molina, Ignacio J.; Unciti-Broceta, Asier; Diaz-Mochon, Juan J.; de las Infantas y Villatoro, Maria J. Pineda; Izquierdo, Luis; Alonso-Padilla, Julio

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

RSC MEDICINAL CHEMISTRY

IF3.6

2021-01-01

OAAI

Wang, Christopher B.; Lorente-Macias, Alvaro; Wells, Carrow; Pickett, Julie E.; Picado, Alfredo; Zuercher, William J.; Axtman, Alison D.

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2

CELL CHEMICAL BIOLOGY

IF7.2

2020-03-01

OAAI

Caplan, Tavia; Lorente-Macias, Alvaro; Stogios, Peter J.; Evdokimova, Elena; Hyde, Sabrina; Wellington, Melanie A.; Liston, Sean; Iyer, Kali R.; Puumala, Emily; Shekhar-Guturja, Tanvi; Robbins, Nicole; Savchenko, Alexei; Krysan, Damian J.; Whitesell, Luke; Zuercher, William J.; Cowen, Leah E.

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-10-23

OAAI

Wells, Carrow; Counago, Rafael M.; Limas, Juanita C.; Almeida, Tuanny L.; Cook, Jeanette Gowen; Drewry, David H.; Elkins, Jonathan M.; Gileadi, Opher; Kapadia, Nirav R.; Lorente-Macias, Alvaro; Pickett, Julie E.; Riemen, Alexander; Ruela-de-Sousa, Roberta R.; Willson, Timothy M.; Zhang, Cunyu; Zuercher, William J.; Zutshi, Reena; Axtman, Alison D.

研究方向