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古

古练权 (Lian-Quan Gu)

sun yatsen university教授

H指数:49

被引数:7,367

个人简介

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教育背景

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工作经历

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荣誉奖项

国家级精品课程（2004）
全国普通高等学校教材二等奖（2002）

Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2019-07-0427

OAAI

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

IF4.6

2018-06-1223

OAAI

Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-05-019

PREAI

Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2018-02-019

PREAI

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-08-0436

PREAI

New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-2847

PREAI

Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2017-06-2136

OAAI

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-1674

PREAI

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-02-1342

PREAI

Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-02-0117

PREAI

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

NUCLEIC ACIDS RESEARCH

IF13.1

2016-12-0689

OAAI

Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres

CELL CHEMICAL BIOLOGY

IF7.2

2016-10-01106

OAAI

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole

BIOSENSORS & BIOELECTRONICS

IF10.5

2016-09-0127

PRE

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2016-08-15119

PREAI

A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes

对噻唑橙的简单结构修饰以提高G-四链体的选择性检测

DYES AND PIGMENTS

IF4.2

2016-03-0118

PREAI

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-12-2143

PREAI

Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-12-0130

PREAI

A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology

SCIENTIFIC REPORTS

IF3.9

2015-11-2527

OAAI

Role of Hairpin-Quadruplex DNA Secondary Structural Conversion in the Promoter of hnRNP K in Gene Transcriptional Regulation

ORGANIC LETTERS

IF5

2015-09-0213

PREAI

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

6-取代吲哚并喹啉二酮类催化DNA拓扑异构酶I抑制剂的合成及生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2015-08-0118

OAAI