未登录 Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators Perkins, James J. J.; McQuade, Paul; Bungard, Christopher J. J.; Diamond, Tracy L. L.; Gantert, Liza T. T.; Gotter, Anthony L. L.; Hanney, Barbara; Hills, Ivory D. D.; Hurzy, Danielle M. M.; Joshi, Aniket; Kern, Jonathan T. T.; Schlegel, Kelly-Ann S.; Manikowski, Jesse J. J.; Meng, Zhaoyang; O'Brien, Julie A. A.; Roecker, Anthony J. J.; Smith, Sean M. M.; Uslaner, Jason M. M.; Hostetler, Eric; Meissner, Robert S. S. 分享 收藏
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation Hong, Chuan; Byrne, Noel J.; Zamlynny, Beata; Tummala, Srivanya; Xiao, Li; Shipman, Jennifer M.; Partridge, Andrea T.; Minnick, Christina; Breslin, Michael J.; Rudd, Michael T.; Stachel, Shawn J.; Rada, Vanessa L.; Kern, Jeffrey C.; Armacost, Kira A.; Hollingsworth, Scott A.; O'Brien, Julie A.; Hall, Dawn L.; McDonald, Terrence P.; Strickland, Corey; Brooun, Alexei; Soisson, Stephen M.; Hollenstein, Kaspar 分享 收藏
Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F}-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs) Walji, Abbas M.; Hostetler, Eric D.; Selnick, Harold; Zeng, Zhizhen; Miller, Patricia; Bennacef, Idriss; Salinas, Cristian; Connolly, Brett; Gantert, Liza; Holahan, Marie; O'Malley, Stacey; Purcell, Mona; Riffel, Kerry; Li, Jin; Balsells, Jaume; OBrien, Julie A.; Melquist, Stacey; Soriano, Aileen; Zhang, Xiaoping; Ogawa, Aimie; Xu, Serena; Joshi, Elizabeth; Della Rocca, Joseph; Hess, Fred J.; Schachter, Joel; Hesk, David; Schenk, David; Struyk, Arie; Babaoglu, Kerim; Lohith, Talakad G.; Wang, Yaode; Yang, Kun; Fu, Jianmin; Evelhoch, Jeffrey L.; Coleman, Paul J. 分享 收藏
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI Pero, Joseph E.; Rossi, Michael A.; Kelly, Michael J., III; Lehman, Hannah D. G. F.; Layton, Mark E.; Garbaccio, Robert M.; O'Brien, Julie A.; Magliaro, Brian C.; Uslaner, Jason M.; Huszar, Sarah L.; Fillgrove, Kerry L.; Tang, Cuyue; Kuo, Yuhsin; Joyce, Leo A.; Sherer, Edward C.; Jacobson, Marlene A. 分享 收藏
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Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor Garbaccio, Robert M.; Brnardic, Edward J.; Fraley, Mark E.; Hartman, George D.; Hutson, Pete H.; O'Brien, Julie A.; Magliaro, Brian C.; Uslaner, Jason M.; Huszar, Sarah L.; Fillgrove, Kerry L.; Small, James H.; Tang, Cuyue; Kuo, Yuhsin; Jacobson, Marlene A. 分享 收藏
A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies Zeng, Zhizhen; O'Brien, Julie A.; Lemaire, Wei; O'Malley, Stacey S.; Miller, Patricia J.; Zhao, Zhijian; Wallace, Michael A.; Raab, Conrad; Lindsley, Craig W.; Sur, Cyrille; Williams, David L., Jr. 分享 收藏
Difference in mGluR5 interaction between positive allosteric modulators from two structural classes 来自两个结构课程的正变构调节剂之间mGluR5相互作用的差异 Williams, DL; O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Wisnoski, DD; Lindsley, CW; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ 分享 收藏
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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models Kinney, GG; O'Brien, JA; Lemaire, W; Burno, M; Bickel, DJ; Clements, MK; Chen, TB; Wisnoski, DD; Lindsley, CW; Tiller, PR; Smith, S; Jacobson, MA; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo Lindsley, CW; Wisnoski, DD; Leister, WH; O'Brien, JA; Lemaire, W; Williams, DL; Burno, M; Sur, C; Kinney, GG; Pettibone, DJ; Tiller, PR; Smith, S; Duggan, M; Hartman, GD; Conn, PJ; Huff, JR 分享 收藏
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain O'Brien, JA; Lemaire, W; Wittmann, M; Jacobson, MA; Ha, SN; Wisnoski, DD; Lindsley, CW; Schaffhauser, HJ; Rowe, B; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment Marino, MJ; Williams, DL; O'Brien, JA; Valenti, O; McDonald, TP; Clements, MK; Wang, RP; DiLella, AG; Hess, JF; Kinney, GG; Conn, PJ 分享 收藏
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Lindsley, CW; Schaffhauser, HJ; Sur, C; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
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Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist Williams, DL; Murphy, KL; Nolan, NA; OBrien, JA; Lis, EV; Pettibone, DJ; Clineschmidt, BV; Krause, SM; Veber, DF; Naylor, EM; Chakravarty, PK; Walsh, TF; Dhanoa, DM; Chen, A; Bagley, SW; Fitch, KJ; Greenlee, WJ 分享 收藏
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