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J

Jan Konvalinka

Academy of Science of the Czech Republic

48H指数
252论文数
7.2K被引数
收录论文 86
发表时间
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Making Prodrugs Stick Around: Engineering Protease-Activated Tumor Retention使前药停留：工程化蛋白酶激活的肿瘤滞留
errACS Central Science
IF10.4
err2026-07-09
err0
errOAAI
errRobin Kryštůfek; Jan Konvalinka
err分享
err收藏
CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive MacrophagesCD64靶向聚合物-药物偶联物利用组织蛋白酶K依赖的载荷释放以选择性清除免疫抑制性巨噬细胞
errMolecular Pharmaceutics
IF4.5
err2026-04-21
err0
errOAAI
errDominik Musil; Markéta Krhutová; Kristýna Blažková; Anežka Kramná; Andrea Brázdová; Barbora Výmolová; Magdalena Houdová Megová; Martin Hadzima; Robin Kryštůfek; Vladimír Šubr; Libor Kostka; Tomáš Etrych; Tereza Ormsby; Pavel Šácha; Jakub Abramson; Jan Konvalinka
err分享
err收藏
Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-12-01
err0
PREAI
errSinkeviciute, Ugne; Simova, Magdalena; Stanik, Radek; Postova Slavetinska, Lenka; Blazkova, Kristyna; Sacha, Pavel; Lepsik, Martin; Rezac, Jan; Konvalinka, Jan; Ormsby, Tereza; Tichy, Michal; Hocek, Michal
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Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights靶向裂谷热病毒聚合酶：抗性机制与结构见解
errACS Infectious Diseases
IF3.8
err2025-10-30
err0
errOAAI
errMichal Král’; Amiyaranjan Das; Tomáš Kotačka; Anna Blahošová; Veronika Liščáková; Jan Hodek; Jan Konvalinka; Gabriel Demo; Milan Kožíšek
err分享
err收藏
PRECLINICAL EVALUATION OF ALPHA-KETOAMIDE-BASED FAP RADIOLIGANDS FOR TARGETING BRAIN METASTASES基于α-酮酰胺的FAP放射性配体靶向脑转移瘤的体外评价
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errVymola, P.; Simkova, A.; Vetrik, M.; Sidej, N.; Dusa, M.; Kucka, J.; Vymolova, B.; Ormsby, T.; Trajhan, F.; Konvalinka, J.; Hruby, M.; Sacha, P.; Sedo, A.; Busek, P.
err分享
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Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors超越天然黄酮类化合物：探索流感核酸内切酶抑制剂的生物等价性在设计与合成中的应用
errRSC Med. Chem.
IF3.6
err2025-08-22
err0
errOAAI
errRóbert Reiberger; Michal Kráľ; Kateřina Radilová; Tomáš Kotačka; Martin Dračínský; Artem Tsalyy; Jiří Brynda; Pavel Majer; Jan Konvalinka; Milan Kožíšek; Aleš Machara
err分享
err收藏
Identification of 6-Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5′-Nucleotidase (CD73)鉴定6-芳基-7-脱氮嘌呤核糖核苷磷酸酯作为外源性5'-核苷酸酶(CD73)的抑制剂
errACS Pharmacology & Translational Science
IF3.7
err2025-07-17
err0
errOAAI
errMagdalena Šímová; Tereza Ormsby; Ugnė Šinkevičiu̅tė; Lucia Sirotová Veselovská; Kateřina Čermáková; Martin Hadzima; Lenka Bartoň; Jana Staňurová; Anežka Kramná; Pavel Šácha; Michal Tichý; Michal Hocek; Jan Konvalinka; Kristyna Blazkova
err分享
err收藏
3′-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure–Activity Relationship Analysis, and Structural Characterization of Protein Complex3′-去氧紫草宁-4-甲酰胺作为甲型流感病毒核糖核酸酶抑制剂：合成、构效关系分析及蛋白质复合物结构表征
errChemMedChem
IF3.4
err2025-07-03
err0
PREAI
errMichal Kráľ; Tomáš Kotačka; Róbert Reiberger; Gabriela Panýrková; Kateřina Radilová; Zuzana Osifová; Miroslav Flieger; Jan Konvalinka; Pavel Majer
err分享
err收藏
On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents在树脂上组装新型抗新型隐球菌May1大环抑制剂：通往强效抗真菌药物的一条途径
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-22
err0
errOAAI
errKrystufek, Robin; Verner, Vaclav; Sacha, Pavel; Hadzima, Martin; Trajhan, Filip; Starkova, Jana; Tloustova, Eva; Dvorakova, Alexandra; Pecina, Adam; Brynda, Jiri; Chalupsky, Karel; Hajek, Miroslav; Boucher, Michael J.; Majer, Pavel; Rezac, Jan; Madhani, Hiten D.; Craik, Charles S.; Konvalinka, Jan
err分享
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The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase
errEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
IF4.7
err2025-02-01
err0
errOAAI
errCermakova, Katerina; Gregor, Jiri; Kral, Michal; Karlukova, Elena; Navrati, Vaclav; Reiberger, Robert; Albinana, Carlos Berenguer; Bechynsky, Vit; Majer, Pavel; Konvalinka, Jan; Machara, Ales; Kozisek, Milan
err分享
err收藏
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-01-01
err0
errOAAI
errNovotny, Pavel; Humpolickova, Jana; Novakova, Veronika; Stanchev, Stancho; Strisovsky, Kvido; Zgarbova, Michala; Weber, Jan; Krystufek, Robin; Starkova, Jana; Hradilek, Martin; Moravcova, Adela; Gunterova, Jana; Bach, Kathrin; Majer, Pavel; Konvalinka, Jan; Majerova, Tatana
err分享
err收藏
Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
errOAAI
errCermakova, Katerina; Simkova, Adela; Wichterle, Filip; Krystufek, Robin; Stanurova, Jana; Vanickova, Zdislava; Busek, Petr; Konvalinka, Jan; Sacha, Pavel
err分享
err收藏
3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex
errCHEMMEDCHEM
IF3.4
err2024-11-11
err1
PREAI
errKral, Michal; Kotacka, Tomas; Reiberger, Robert; Panyrkova, Gabriela; Radilova, Katerina; Osifova, Zuzana; Flieger, Miroslav; Konvalinka, Jan; Majer, Pavel; Kozisek, Milan; Machara, Ales
err分享
err收藏
Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker基于聚合物的抗体模拟物 (iBodies) 靶向人类PD-L1并作为有效的免疫检查点阻滞剂
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-06-01
err0
errOAAI
errZamani, Mohammad Reza; Hadzima, Martin; Blazkova, Kristyna; Subr, Vladimir; Ormsby, Tereza; Celis-Gutierrez, Javier; Malissen, Bernard; Kostka, Libor; Etrych, Tomas; Sacha, Pavel; Konvalinka, Jan
err分享
err收藏
Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-02-20
err3
errOAAI
errSedlak, Frantisek; Kvasnicka, Ales; Maresova, Barbora; Brumarova, Radana; Dobesova, Dana; Dostalova, Katerina; Sramkova, Karolina; Pehr, Martin; Sacha, Pavel; Friedecky, David; Konvalinka, Jan
err分享
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Viral proteases as therapeutic targets
errMOLECULAR ASPECTS OF MEDICINE
IF10.3
err2022-12-01
err20
errOAAI
errMajerova, Tatana; Konvalinka, Jan
err分享
err收藏
Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia
errSCIENTIFIC REPORTS
IF3.9
err2022-09-13
err2
errOAAI
errGrinceviciene, Svitrigaile; Vaitkiene, Daiva; Kanopiene, Daiva; Vanseviciute, Rasa; Tykvart, Jan; Sukovas, Arturas; Celiesiute, Joana; Didziokiene, Ernesta Ivanauskaite; Cizauskas, Arvydas; Laurinaviciene, Aida; Kral, Vlastimil; Hlavackova, Anna; Zemanova, Jitka; Stravinskiene, Dovile; Sliziene, Aiste; Petrosiute, Agne; Petrauskas, Vytautas; Balsyte, Renata; Grincevicius, Jonas; Navratil, Vaclav; Jahn, Ullrich; Konvalinka, Jan; Zvirbliene, Aurelija; Matulis, Daumantas; Matuliene, Jurgita
err分享
err收藏
Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2021-11-01
err11
errOAAI
errSimkova, Adela; Ormsby, Tereza; Sidej, Natan; Slavetinska, Lenka Postova; Brynda, Jiri; Beranova, Jana; Sacha, Pavel; Majer, Pavel; Konvalinka, Jan
err分享
err收藏
The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody)
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2021-11-01
err3
errOAAI
errBlazkova, Kristyna; Beranova, Jana; Hradilek, Martin; Kostka, Libor; Subr, Vladimir; Etrych, Tomas; Sacha, Pavel; Konvalinka, Jan
err分享
err收藏
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-05-18
err18
errOAAI
errKrystufek, Robin; Sacha, Pavel; Starkova, Jana; Brynda, Jiri; Hradilek, Martin; Tloust'ova, Eva; Grzymska, Justyna; Rut, Wioletta; Boucher, Michael J.; Drag, Marcin; Majer, Pavel; Hajek, Miroslav; Rezacova, Pavlina; Madhani, Hiten D.; Craik, Charles S.; Konvalinka, Jan
err分享
err收藏

研究方向

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合作学者
合作期刊
S
Stefan W. Hell
H 指数: 137 · 论文数: 729
R
Radek Zbořil
H 指数: 121 · 论文数: 917
P
Pavel Hobza
H 指数: 115 · 论文数: 704
K
Kay Hofmann
H 指数: 111 · 论文数: 473
B
Bernard Malissen
H 指数: 109 · 论文数: 820
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