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M

Magdalena M. Szewczyk

university of toronto
H指数:33
被引数:3,843

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ABHD2 activity is not required for the non-genomic action of progesterone on human sperm

ABHD2活性并非孕酮对人类精子非基因组作用所必需

Human Reproduction
IF6.1
2026-05-290
OA
Madison Edwards; Alexandra Amaral; Eve M Carter; Oliver Arnolds; Karen Vester; Anna Thrun; Edvard Wigren; Evert Homan; Pauline Ribera; Kirsty Bentley; Martin Haraldsson; Nmesoma Theo-Emegano; Peter Loppnau; Magdalena M Szewczyk; Michelle A Cao; Dalia Barsyte-Lovejoy; Nicole Dittmar; Anika Hans; Mandy Weber; Jens Münchow; W Felix Zhu; Louisa Temme; Christoph Brenker; Timo Strünker; Michael Sundström; Matthew H Todd; Aled M Edwards; Ralf Lesche; Opher Gileadi; Claudia Tredup; null
OICR-41103 as a chemical probe for the DCAF1 WD40 domain

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Communications Biology
IF5.1
2025-07-190
OAAI
Serah W. Kimani; Mahmoud Noureldin; Brian Wilson; Laurent Hoffer; Stuart R. Green; Magdalena M. Szewczyk; Héctor González-Álvarez; Mohammed Mohammed; Manuel Chan; Chiara Krausser; Alice Shi Ming Li; Taraneh Hajian; Sarah Tucker; Dhananjay Joshi; Punit Saraon; Brigitte Thériault; Ji Sup Kim; Vijayaratnam Santhakumar; Peter Loppnau; Yanjun Li; Almagul Seitova; Aiping Dong; Taira Kiyota; Tobias Hammann; Paul Gehrtz; Bhashant Patel; Vaibhavi Rathod; Anand Vala; Bhimsen Rout; Paras Jagodra; Peter J. Brown; Ahmed Aman; Jailall Ramnauth; Gennady Poda; David Uehling; Cheryl H. Arrowsmith; Dalia Barsyte-Lovejoy; Richard Marcellus; Suzanne Ackloo; Ahmed Mamai; Rima Al-awar; Levon Halabelian
Recruitment of FBXO22 for targeted degradation of NSD2

招募FBXO22靶向降解NSD2

NATURE CHEMICAL BIOLOGY
IF13.7
2024-07-047
PRE
Nie, David Y.; Tabor, John R.; Li, Jianping; Kutera, Maria; St-Germain, Jonathan; Hanley, Ronan P.; Wolf, Esther; Paulakonis, Ethan; Kenney, Tristan M. G.; Duan, Shili; Shrestha, Suman; Owens, Dominic D. G.; Maitland, Matthew E. R.; Pon, Ailing; Szewczyk, Magdalena; Lamberto, Anthony Joseph; Menes, Michael; Li, Fengling; Penn, Linda Z.; Barsyte-Lovejoy, Dalia; Brown, Nicholas G.; Barsotti, Anthony M.; Stamford, Andrew W.; Collins, Jon L.; Wilson, Derek J.; Raught, Brian; Licht, Jonathan D.; James, Lindsey I.; Arrowsmith, Cheryl H.
A chemical probe to modulate human GID4 Pro/N-degron interactions
NATURE CHEMICAL BIOLOGY
IF13.7
2024-05-214
PRE
Owens, Dominic D. G.; Maitland, Matthew E. R.; Yazdi, Aliakbar Khalili; Song, Xiaosheng; Reber, Viviane; Schwalm, Martin P.; Machado, Raquel A. C.; Bauer, Nicolas; Wang, Xu; Szewczyk, Magdalena M.; Dong, Cheng; Dong, Aiping; Loppnau, Peter; Calabrese, Matthew F.; Dowling, Matthew S.; Lee, Jisun; Montgomery, Justin I.; O'Connell, Thomas N.; Subramanyam, Chakrapani; Wang, Feng; Adamson, Ella C.; Schapira, Matthieu; Gstaiger, Matthias; Knapp, Stefan; Vedadi, Masoud; Min, Jinrong; Lajoie, Gilles A.; Barsyte-Lovejoy, Dalia; Owen, Dafydd R.; Schild-Poulter, Caroline; Arrowsmith, Cheryl H.
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
RSC MEDICINAL CHEMISTRY
IF3.6
2024-01-013
OA
Yazdi, Aliakbar Khalili; Perveen, Sumera; Dong, Cheng; Song, Xiaosheng; Dong, Aiping; Szewczyk, Magdalena M.; Calabrese, Matthew F.; Casimiro-Garcia, Agustin; Chakrapani, Subramanyam; Dowling, Matthew S.; Ficici, Emel; Lee, Jisun; Montgomery, Justin I.; O'Connell, Thomas N.; Skrzypek, Grzegorz J.; Tran, Tuan P.; Troutman, Matthew D.; Wang, Feng; Young, Jennifer A.; Min, Jinrong; Barsyte-Lovejoy, Dalia; Brown, Peter J.; Santhakumar, Vijayaratnam; Arrowsmith, Cheryl H.; Vedadi, Masoud; Owen, Dafydd R.
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration

HC-258的开发，一种共价丙烯酰胺TEAD抑制剂，可减少基因表达和细胞迁移

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-11-306
PRE
Fnaiche, Ahmed; Chan, Hwai-Chien; Paquin, Alexis; Suarez, Narjara Gonzalez; Vu, Victoria; Li, Fengling; Allali-Hassani, Abdellah; Cao, Michelle Ada; Szewczyk, Magdalena M.; Bolotokova, Albina; Allemand, Frederic; Gelin, Muriel; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Vedadi, Masoud; Guichou, Jean-Francois; Annabi, Borhane; Gagnon, Alexandre
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-273
OAAI
Harding, Rachel J.; Franzoni, Ivan; Mann, Mandeep K.; Szewczyk, Magdalena M.; Mirabi, Bijan; de Freitas, Renato Ferreira; Owens, Dominic D. G.; Ackloo, Suzanne; Scheremetjew, Alexej; Juarez-Ornelas, Kevin A.; Sanichar, Randy; Baker, Rachel J.; Dank, Christian; Brown, Peter J.; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Schapira, Matthieu; Lautens, Mark; Arrowsmith, Cheryl H.
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2

发现一种有效且选择性的靶向NSD2降解剂，用于还原H3K36me2

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2023-03-2825
PRE
Hanley, Ronan P.; Nie, David Y.; Tabor, John R.; Li, Fengling; Sobh, Amin; Xu, Chenxi; Barker, Natalie K.; Dilworth, David; Hajian, Taraneh; Gibson, Elisa; Szewczyk, Magdalena M.; Brown, Peter J.; Barsyte-Lovejoy, Dalia; Herring, Laura E.; Wang, Gang Greg; Licht, Jonathan D.; Vedadi, Masoud; Arrowsmith, Cheryl H.; James, Lindsey I.
Discovery of Nanomolar DCAF1 Small Molecule Ligands
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-03-2220
OAAI
Li, Alice Shi Ming; Kimani, Serah; Wilson, Brian; Noureldin, Mahmoud; Gonzalez-Alvarez, Hector; Mamai, Ahmed; Hoffer, Laurent; Guilinger, John P.; Zhang, Ying; von Rechenberg, Moritz; Disch, Jeremy S.; Mulhern, Christopher J.; Slakman, Belinda L.; Cuozzo, John W.; Dong, Aiping; Poda, Gennady; Mohammed, Mohammed; Saraon, Punit; Mittal, Manish; Modh, Prati k; Rathod, Vaibhavi; Patel, Bhashant; Ackloo, Suzanne; Santhakumar, Vijayaratnam; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Marcellus, Richard; Guie, Marie-Aude; Keefe, Anthony D.; Brown, Peter J.; Halabelian, Levon; Al-awar, Rima; Vedadi, Masoud
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
NATURE COMMUNICATIONS
IF15.7
2023-03-1310
OAAI
Dahlin, Jayme L.; Hua, Bruce K.; Zucconi, Beth E.; Nelson, Shawn D.; Singh, Shantanu; Carpenter, Anne E.; Shrimp, Jonathan H.; Lima-Fernandes, Evelyne; Wawer, Mathias J.; Chung, Lawrence P. W.; Agrawal, Ayushi; O'Reilly, Mary; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena; Li, Fengling; Lak, Parnian; Cuellar, Matthew; Cole, Philip A.; Meier, Jordan L.; Thomas, Tim; Baell, Jonathan B.; Brown, Peter J.; Walters, Michael A.; Clemons, Paul A.; Schreiber, Stuart L.; Wagner, Bridget K.
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

PRMT抑制在三阴性乳腺癌中诱导病毒模仿反应

NATURE CHEMICAL BIOLOGY
IF13.7
2022-05-1660
OAAI
Wu, Qin; Nie, David Y.; Ba-alawi, Wail; Ji, YiShuai; Zhang, ZiWen; Cruickshank, Jennifer; Haight, Jillian; Ciamponi, Felipe E.; Chen, Jocelyn; Duan, Shili; Shen, Yudao; Liu, Jing; Marhon, Sajid A.; Mehdipour, Parinaz; Szewczyk, Magdalena M.; Dogan-Artun, Nergiz; Chen, WenJun; Zhang, Lan Xin; Deblois, Genevieve; Prinos, Panagiotis; Massirer, Katlin B.; Barsyte-Lovejoy, Dalia; Jin, Jian; De Carvalho, Daniel D.; Haibe-Kains, Benjamin; Wang, XiaoJia; Cescon, David W.; Lupien, Mathieu; Arrowsmith, Cheryl H.
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1
COMMUNICATIONS BIOLOGY
IF5.1
2021-12-0827
OAAI
Harding, Rachel J.; Deme, Justin C.; Hevler, Johannes F.; Tamara, Sem; Lemak, Alexander; Cantle, Jeffrey P.; Szewczyk, Magdalena M.; Begeja, Nola; Goss, Siobhan; Zuo, Xiaobing; Loppnau, Peter; Seitova, Alma; Hutchinson, Ashley; Fan, Lixin; Truant, Ray; Schapira, Matthieu; Carroll, Jeffrey B.; Heck, Albert J. R.; Lea, Susan M.; Arrowsmith, Cheryl H.
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

靶向PWWP结构域的化学探针改变了NSD2核仁定位

NATURE CHEMICAL BIOLOGY
IF13.7
2021-11-1553
OA
Dilworth, David; Hanley, Ronan P.; de Freitas, Renato Ferreira; Allali-Hassani, Abdellah; Zhou, Mengqi; Mehta, Naimee; Marunde, Matthew R.; Ackloo, Suzanne; Machado, Raquel Arminda Carvalho; Yazdi, Aliakbar Khalili; Owens, Dominic D. G.; Vu, Victoria; Nie, David Y.; Alqazzaz, Mona; Marcon, Edyta; Li, Fengling; Chau, Irene; Bolotokova, Albina; Qin, Su; Lei, Ming; Liu, Yanli; Szewczyk, Magdalena M.; Dong, Aiping; Kazemzadeh, Sina; Abramyan, Tigran; Popova, Irina K.; Hall, Nathan W.; Meiners, Matthew J.; Cheek, Marcus A.; Gibson, Elisa; Kireev, Dmitri; Greenblatt, Jack F.; Keogh, Michael-C; Min, Jinrong; Brown, Peter J.; Vedadi, Masoud; Arrowsmith, Cheryl H.; Barsyte-Lovejoy, Dalia; James, Lindsey, I; Schapira, Matthieu
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid

氟芬那酸小分子TEAD抑制剂LM98的研制

CHEMMEDCHEM
IF3.4
2021-07-2821
PREAI
Melin, Lea; Abdullayev, Shuay; Fnaiche, Ahmed; Vu, Victoria; Suarez, Narjara Gonzalez; Zeng, Hong; Szewczyk, Magdalena M.; Li, Fengling; Senisterra, Guillermo; Allali-Hassani, Abdellah; Chau, Irene; Dong, Aiping; Woo, Simon; Annabi, Borhane; Halabelian, Levon; LaPlante, Steven R.; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Gagnon, Alexandre

研究方向

暂未获取到该数据
D
Dalia Baršytė-Lovejoy
H 指数:53论文数:227被引数:1.2万
C
C.H. Arrowsmith
H 指数:112论文数:3,098被引数:4.2万
M
Masoud Vedadi
H 指数:70论文数:400被引数:1.8万
P
Peter J. Brown
H 指数:66论文数:347被引数:1.8万
F
Fengling Li
H 指数:56论文数:258被引数:1.0万
M
Matthieu Schapira
H 指数:60论文数:414被引数:1.7万
M
Mohammad S. Eram
H 指数:23论文数:43被引数:2,051
V
Vijayaratnam Santhakumar
H 指数:22论文数:126被引数:1,817
L
Levon Halabelian
H 指数:22论文数:118被引数:1,384
D
David Smil
H 指数:28论文数:115被引数:3,017