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D

David Smil

University of Toronto
H指数:28
被引数:3,018

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Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer

作为Hippo通路调节剂，用于癌症治疗的强效且选择性的双NUAK/MARK抑制剂的发现与开发

European Journal of Medicinal Chemistry
IF5.9
2026-03-310
PRE
David Smil; Yong Liu; Tao Xin; Taira Kiyota; Ahmed Aman; Julie Grouleff; Laurent Hoffer; Dhananjay C. Joshi; Mohammad R. Inanlou; Siyuan Song; Daniel Y.L. Mao; Abiodun A. Ogunjimi; Victor Pau; Fiona D. Chini; Igor Kurinov; Ying Zhang; Anh Thu Nguyen; Jeffrey L. Wrana; Frank Sicheri; Liliana Attisano
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-07-180
OAAI
Nemec, Vaclav; Remes, Marek; Benovsky, Petr; Boeck, Michael C.; Srankova, Eliska; Wong, Jong Fu; Cros, Julien; Williams, Eleanor; Tse, Lap Hang; Smil, David; Ensan, Deeba; Isaac, Methvin B.; Al-Awar, Rima; Gomolkova, Regina; Ursachi, Vlad-Constantin; Fafilek, Bohumil; Kahounova, Zuzana; Vichova, Rachel; Vacek, Ondrej; Berger, Benedict-Tilman; Wells, Carrow I.; Corona, Cesear R.; Vasta, James D.; Robers, Matthew B.; Krejci, Pavel; Soucek, Karel; Bullock, Alex N.; Knapp, Stefan; Paruch, Kamil
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

选择性PRMT4抑制剂的合理设计和合成: 开发癌症治疗药物的新化学型 **

CHEMMEDCHEM
IF3.4
2021-03-0411
OA
Sutherland, Mathew; Li, Alice; Kaghad, Anissa; Panagopoulos, Dimitrios; Li, Fengling; Szewczyk, Magdalena; Smil, David; Scholten, Cora; Bouche, Lea; Stellfeld, Timo; Arrowsmith, Cheryl H.; Barsyte, Dalia; Vedadi, Masoud; Hartung, Ingo V.; Steuber, Holger; Britton, Robert; Santhakumar, Vijayaratnam
Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-08-1117
OAAI
Smil, David; Wong, Jong Fu; Williams, Eleanor P.; Adamson, Roslin J.; Howarth, Alison; McLeod, David A.; Mamai, Ahmed; Kim, Soyoung; Wilson, Brian J.; Kiyota, Taira; Aman, Ahmed; Owen, Julie; Poda, Gennady; Horiuchi, Kurumi Y.; Kuznetsova, Ekaterina; Ma, Haiching; Hamblin, J. Nicole; Cramp, Sue; Roberts, Owen G.; Edwards, Aled M.; Uehling, David; Al-awar, Rima; Bullock, Alex N.; O'Meara, Jeff A.; Isaac, Methvin B.
Identification and characterization of the first fragment hits for SETDB1 Tudor domain
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2019-09-0114
OAAI
Mader, Pavel; Mendoza-Sanchez, Rodrigo; Iqbal, Aman; Dong, Aiping; Dobrovetsky, Elena; Corless, Victoria B.; Liew, Sean K.; Houliston, Scott R.; De Freitas, Renato Ferreira; Smil, David; Dela Sena, Carlo C.; Kennedy, Steven; Diaz, Diego B.; Wu, Hong; Dombrovski, Ludmila; Allali-Hassani, Abdellah; Min, Jinrong; Schapira, Matthieu; Vedadi, Masoud; Brown, Peter J.; Santhakumar, Vijayaratnam; Yudin, Andrei K.; Arrowsmith, Cheryl H.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
NATURE COMMUNICATIONS
IF15.7
2019-01-0388
OAAI
Scheer, Sebastian; Ackloo, Suzanne; Medina, Tiago S.; Schapira, Matthieu; Li, Fengling; Ward, Jennifer A.; Lewis, Andrew M.; Northrop, Jeffrey P.; Richardson, Paul L.; Kaniskan, H. Umit; Shen, Yudao; Liu, Jing; Smil, David; McLeod, David; Zepeda-Velazquez, Carlos A.; Luo, Minkui; Jin, Jian; Barsyte-Lovejoy, Dalia; Huber, Kilian V. M.; De Carvalho, Daniel D.; Vedadi, Masoud; Zaph, Colby; Brown, Peter J.; Arrowsmith, Cheryl H.
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

蛋白质精氨酸甲基转移酶3 (PRMT3) 的有效和选择性变构抑制剂的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-01-0528
OAAI
Kaniskan, H. Umit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6

发现蛋白质精氨酸甲基转移酶4和蛋白质精氨酸甲基转移酶6的有效，选择性和细胞活性双重抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-09-1569
OAAI
Shen, Yudao; Szewczyk, Magdalena M.; Eram, Mohammad S.; Smil, David; Kaniskan, H. Umit; de Freitas, Renato Ferreira; Senisterra, Guillermo; Li, Fengling; Schapira, Matthieu; Brown, Peter J.; Arrowsmith, Cheryl H.; Barsyte-Lovejoy, Dalia; Liu, Jing; Vedadi, Masoud; Jin, Jian
Functional interdependence of BRD4 and DOT1L in MLL leukemia
NATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
2016-06-1391
OA
Gilan, Omer; Lam, Enid Y. N.; Becher, Isabelle; Lugo, Dave; Cannizzaro, Ester; Joberty, Gerard; Ward, Aoife; Wiese, Meike; Fong, Chun Yew; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; MacPherson, Laura; Weng, Chen-Fang; Chan, Yih-Chih; Ghisi, Margherita; Smil, David; Carpenter, Christopher; Brown, Peter; Garton, Neil; Blewitt, Marnie E.; Bannister, Andrew J.; Kouzarides, Tony; Huntly, Brian J. P.; Johnstone, Ricky W.; Drewes, Gerard; Dawson, Sarah-Jane; Arrowsmith, Cheryl H.; Grandi, Paola; Prinjha, Rab K.; Dawson, Mark A.
Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-0981
PREAI
Getlik, Matthaeus; Smil, David; Zepeda-Velazquez, Carlos; Bolshan, Yuri; Poda, Gennady; Wu, Hong; Dong, Aiping; Kuznetsova, Ekaterina; Marcellus, Richard; Senisterra, Guillermo; Dombrovski, Ludmila; Hajian, Taraneh; Kiyota, Taira; Schapira, Matthieu; Arrowsmith, Cheryl H.; Brown, Peter J.; Vedadi, Masoud; Al-awar, Rima
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

发现有效的I类蛋白精氨酸甲基转移酶片段抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-01-2932
PREAI
de Freitas, Renato Ferreira; Eram, Mohammad S.; Szewczyk, Magdalena M.; Steuber, Holger; Smil, David; Wu, Hong; Li, Fengling; Senisterra, Guillermo; Dong, Aiping; Brown, Peter J.; Hitchcock, Marion; Moosmayer, Dieter; Stegmann, Christian M.; Egner, Ursula; Arrowsmith, Cheryl; Barsyte-Loyejoy, Dalia; Vedadi, Masoud; Schapira, Matthieu
Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia (vol 11, pg 571, 2015 )
NATURE CHEMICAL BIOLOGY
IF13.7
2015-09-171
OAAI
Grebien, Florian; Vedadi, Masoud; Getlik, Matthaeus; Giambruno, Roberto; Grover, Amit; Avellino, Roberto; Skucha, Anna; Vittori, Sarah; Kuznetsova, Ekaterina; Smil, David; Barsyte-Lovejoy, Dalia; Li, Fengling; Poda, Gennadiy; Schapira, Matthieu; Wu, Hong; Dong, Aiping; Senisterra, Guillermo; Stukalov, Alexey; Huber, Kilian V. M.; Schoenegger, Andreas; Marcellus, Richard; Bilban, Martin; Bock, Christoph; Brown, Peter J.; Zuber, Johannes; Bennett, Keiryn L.; Al-awar, Rima; Delwel, Ruud; Nerlov, Claus; Arrowsmith, Cheryl H.; Superti-Furga, Giulio

研究方向

暂未获取到该数据
M
Masoud Vedadi
H 指数:70论文数:400被引数:1.8万
M
Matthieu Schapira
H 指数:60论文数:414被引数:1.7万
C
C.H. Arrowsmith
H 指数:112论文数:3,098被引数:4.2万
P
Peter J. Brown
H 指数:66论文数:347被引数:1.8万
F
Fengling Li
H 指数:56论文数:258被引数:1.0万
D
Dalia Baršytė-Lovejoy
H 指数:53论文数:227被引数:1.2万
R
Rima Al‐awar
H 指数:42论文数:252被引数:5,873
A
Aiping Dong
H 指数:49论文数:218被引数:7,743
M
Magdalena M. Szewczyk
H 指数:33论文数:110被引数:3,845
G
Guillermo Senisterra
H 指数:40论文数:109被引数:5,006