logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
D

Doyle J. Cassar

astrazeneca
H指数:8
被引数:304

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Discovery of AZD9750; an Orally Bioavailable Androgen Receptor Degrader for the Treatment of Prostate Cancer
Journal of Medicinal Chemistry
IF6.8
2026-01-290
PRE
James S. Scott; Laura Evans; Peter C. Astles; Argyrides Argyrou; Sharan K. Bagal; David Beattie; Erin L. Braybrooke; Doyle J. Cassar; Claire Crafter; Coura Diène; Gary Fairley; Charlene Fallan; Graham Fraser; Nuria Galeano-Dalmau; Thomas G. Hammond; Andreas K. Hock; Thomas Jones; Jasper Komen; Gillian M. Lamont; Chrysiis Michaloglou; Michael J. Niedbala; Antonio Ramos-Montoya; Monica C. Rodrigo-Brenni; Martin J. Packer; Stuart Pearson; Andy Pike; Markus Schade; Joseph Shaw; Ziyanda Shologu; Oliver Steward
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-251
PRE
Lucas, Simon C. C.; Milbradt, Alexander G.; Blackwell, J. Henry; Bonomo, Silvia; Brierley, Andrew; Cassar, Doyle J.; Freeman, Jared; Hadfield, Thomas E.; Morrill, Lucas A.; Riemens, Rick; Sarda, Sunil; Schiesser, Stefan; Wiktelius, Daniel; Ahmed, Samiyah; Bostock, Mark J.; Borjesson, Ulf; De Fusco, Claudia; Guerot, Carine; Hargreaves, David; Hewitt, Sarah; Lamb, Michelle L.; Su, Nancy; Whatling, Ryan; Wheeler, Matthew; Kettle, Jason G.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-0311
PRE
Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang

研究方向

暂未获取到该数据
J
Jason G. Kettle
H 指数:31论文数:163被引数:3,394
S
Sharan K. Bagal
H 指数:23论文数:65被引数:1,857
L
Laura Evans
H 指数:9论文数:27被引数:314
G
Graeme R. Robb
H 指数:25论文数:70被引数:2,043
M
Michael S. Bodnarchuk
H 指数:16论文数:40被引数:1,018
G
Gillian M. Lamont
H 指数:16论文数:58被引数:1,626
C
Christopher Phillips
H 指数:66论文数:317被引数:1.3万
L
Libin Liu
H 指数:26论文数:85被引数:3,430
H
Hilary Lewis
H 指数:14论文数:63被引数:1,227
R
Rachel Howells
H 指数:14论文数:37被引数:909