Jianzhang Wu

Wenzhou Medical University

H指数:29

被引数:2,850

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Discovery of novel IKKβ allosteric inhibitors as dual-antioxidant for cerebral ischemia-reperfusion injury therapy by upregulating HO-1 and SLC7A11

新型IKKβ别构抑制剂的发现：通过上调HO-1和SLC7A11作为双抗氧化剂治疗脑缺血再灌注损伤

Bioorganic Chemistry

IF4.7

2026-05-160

PRE

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition (Adv. Sci. 4/2026)

靶向TSHR的核酸适体通过新型变构抑制治疗graves眼病 (Adv. Sci. 4/2026)

Advanced Science

IF14.1

2026-01-190

OAAI

Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors

SCIENCE ADVANCES

IF12.5

2026-01-010

PRE

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

TSHR靶向核酸适配体通过新型别构抑制治疗格雷夫斯眼病

Advanced Science

IF14.1

2025-10-070

OAAI

Design, synthesis and anti-gastric cancer activity of stable Bisamide curcumin analogues

稳定双酰胺姜黄素类似物的设计、合成及其抗胃癌活性

Bioorganic Chemistry

IF4.7

2025-07-230

PRE

Dimercaprol attenuates oxidative stress-induced damage of retinal ganglion cells in an in vitro and in vivo model of traumatic optic neuropathy

二巯丙醇在体外和体内创伤性视神经病变模型中减轻氧化应激对视网膜神经节细胞的损伤

Neuropharmacology

IF4.6

2025-05-210

Design and synthesis of novel antioxidants derived from chalcones and their protective effects on cardiomyocytes by activating Nrf2/ HO-1 pathway

基于查尔酮衍生物的新型抗氧化剂的设计与合成及其通过激活Nrf2/HO-1通路对心肌细胞的保护作用

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IF2.2

2025-04-010

PRE

FGL1 facilitates rather than suppresses anticancer immunity against microsatellite instable gastric cancer

GENES AND IMMUNITY

IF4.5

2024-12-130

PRE

Design and green synthesis of asymmetric 3,4,5-trimethoxyphenyl-inspired 1,5-diaryl-1,4-pentadien-3-ones as potent anti-gastric cancer agents through ROS and JNK-triggered apoptosis

SUSTAINABLE CHEMISTRY AND PHARMACY

IF5.8

2024-12-010

PRE

Green synthesis of neuroprotective spirocyclic chalcone derivatives and their role in protecting against traumatic optic nerve injury

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-010

PRE

WYC-209 suppresses gastric cancer by down-regulating FGF18 via inactivating the STAT3 signaling pathway

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2024-11-010

OAAI

Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer

含有邻甲氧基苯基的环状C7-bridged单羰基姜黄素类似物的设计，合成和评估作为抗胃癌的潜在药物

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2024-02-221

OAAI

WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα

CANCER BIOLOGY & THERAPY

IF4.6

2024-01-046

OAAI

Effect of ultrasonic vacuum drying on the structural characteristics of whole-egg protein powder

LWT-FOOD SCIENCE AND TECHNOLOGY

IF6.6

2024-01-017

OAAI

Biological characteristics of pancreatic ductal adenocarcinoma: Initiation to malignancy, intracellular to extracellular

CANCER LETTERS

IF10.1

2023-10-0112

The role of NLRP12 in inflammatory diseases

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2023-10-018

OAAI

Elucidating the potential effects of point mutations on FGFR3 inhibitor resistance via combined molecular dynamics simulation and community network analysis

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2023-06-030

PRE

Antioxidant and Neuroprotective Xenicane Diterpenes from the Brown Alga Dictyota coriacea

来自褐藻Dictyota coriacea的抗氧化剂和神经保护性Xenicane二萜

ACS OMEGA

IF4.3

2023-02-168

OAAI

Discovery of Anodic Thiourea Oxidation as a Sustainable Counter Reaction to Boost Electro-Reductive Organic Transformations

ACS SUSTAINABLE CHEMISTRY & ENGINEERING

IF7.3

2023-01-306

PRE

Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis (vol 48, pg 579, 2023)

NEUROCHEMICAL RESEARCH

IF3.8

2023-01-200

Jianzhang Wu

个人简介

教育背景

工作经历

荣誉奖项

研究方向