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C

Christophe Rochais

normandie univ
H指数:25
被引数:2,498

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Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity.

设计、合成及生物学评价：经胆碱酯酶激活并释放5-HT<sub>4</sub>R激动剂、具有体内抗遗忘活性的多效前药

European Journal of Medicinal Chemistry
IF5.9
2026-10-100
OAAI
Alice Wang; Caroline Lahogue; Thomas Curel; Caroline Lanthier; Anne-Claire Groo; Audrey Davis; Sophie Corvaisier; Dimitri Fayolle; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Cédric Lecoutey; Sylvie Claeysen; Aurélie Malzert-Fréon; Thomas Freret; Michel Boulouard; Marc Since; Christophe Rochais; Patrick Dallemagne
Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer’s Disease

基于利伐斯明（Rivastigmine）的多效性前药的设计与评估：用于治疗阿尔茨海默病

ACS Chemical Neuroscience
IF3.9
2026-04-130
PRE
Valentin Travers-Lesage; Marc Since; Alice Wang; Audrey Davis; Dimitri Fayolle; Benoit Bernay; Fabrice Modeste; Florian Nachon; Xavier Brazzalotto; Lucie Crouzier; Jana Sopkova-De Oliveira Santos; Tangui Maurice; Patrick Dallemagne; Christophe Rochais
Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

多官能化N-芳基磺酰基吲哚：用于表观遗传学基础治疗帕金森病的(E)-N-羟基-3-{3-[(5-(3-(哌啶-1-基)丙氧基)-1H-吲哚-1-基)磺酰基]苯基}丙烯酰胺（MTP150）的鉴定

International Journal of Molecular Sciences
IF4.9
2026-03-310
OAAI
Mireia Toledano-Pinedo; Alicia Porro-Pérez; Linda Schäker-Hübner; Daniel Diez-Iriepa; Isabel Iriepa; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroz-Płonka; Jadwiga Handzlik; Justyna Godyń; Patrick Dallemagne; Christophe Rochais; Audrey Davis; Marc Since; Belén Pérez; Aina Bellver-Sanchis; Alba Irisarri; Mercè Pallàs; Cristina Solana-Manrique; Francisco López-Muñoz; Lhassane Ismaili; Christian Griñán-Ferré; Nuria Paricio; Finn K. Hansen; Anna Więckowska; José Marco-Contelles
Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer’s disease model.

获得新型强效多效性前药，其靶向丁酰胆碱酯酶和血清素再摄取，并在阿尔茨海默病模型中具有抗遗忘活性。

European Journal of Medicinal Chemistry
IF5.9
2026-02-120
PRE
Valentin Travers--Lesage; Lucie Crouzier; Mirjana Antonijevic; Alice Wang; François-Xavier Toublet; Audrey Davis; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Marc Since; Tangui Maurice; Christophe Rochais; Patrick Dallemagne
Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route

来自小鼠模型的证据支持通过鼻内途径给药将抗哮喘药物bambuterol重新用于治疗阿尔茨海默氏病

COMMUNICATIONS BIOLOGY
IF5.1
2025-02-010
OAAI
Groo, Anne-Claire; Curel, Thomas; Malzert-Freon, Aurelie; Seguy, Line; Bento, Ophelie; Corvaisier, Sophie; Culerier, Thomas; Legrand, Romain; Callizot, Noelle; Henriques, Alexandre; Culley, Georgia; Claeysen, Sylvie; Rochais, Christophe; Dallemagne, Patrick
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Rochais, Christophe; Lecoutey, Cedric; Lalut, Julien; Davis, Audrey; Duval, Emilie; Gaven, Florence; Largilliere, Stacy; Nee, Gerald; Corvaisier, Sophie; Santos, Jana Sopkova de Oliveira; Since, Marc; Freret, Thomas; Legrand, Romain; Callizot, Noelle; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
NATURE COMMUNICATIONS
IF15.7
2024-05-161
OAAI
Mistretta, Maxime; Cimino, Mena; Campagne, Pascal; Volant, Stevenn; Kornobis, Etienne; Hebert, Olivier; Rochais, Christophe; Dallemagne, Patrick; Lecoutey, Cedric; Tisnerat, Camille; Lepailleur, Alban; Ayotte, Yann; LaPlante, Steven R.; Gangneux, Nicolas; Zahorszka, Monika; Kordulakova, Jana; Vichier-Guerre, Sophie; Bonhomme, Frederic; Pokorny, Laura; Albert, Marvin; Tinevez, Jean-Yves; Manina, Giulia

研究方向

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P
Patrick Dallemagne
H 指数:32论文数:289被引数:4,098
C
Cédric Lecoutey
H 指数:16论文数:55被引数:699
A
Audrey Davis
H 指数:18论文数:43被引数:1,290
J
Jana Sopková‐de Oliveira Santos
H 指数:28论文数:222被引数:2,704
M
Marc Since
H 指数:17论文数:61被引数:826
S
Sylvie Claeysen
H 指数:36论文数:109被引数:4,228
S
Sophie Corvaisier
H 指数:16论文数:63被引数:997
T
Thomas Fréret
H 指数:34论文数:200被引数:5,888
M
Michel Boulouard
H 指数:35论文数:148被引数:5,230
S
Sylvain Rault
H 指数:42论文数:508被引数:6,646