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C

Cédric Lecoutey

normandie univ
H指数:16
被引数:699

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Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity.

设计、合成及生物学评价：经胆碱酯酶激活并释放5-HT<sub>4</sub>R激动剂、具有体内抗遗忘活性的多效前药

European Journal of Medicinal Chemistry
IF5.9
2026-10-100
OAAI
Alice Wang; Caroline Lahogue; Thomas Curel; Caroline Lanthier; Anne-Claire Groo; Audrey Davis; Sophie Corvaisier; Dimitri Fayolle; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Cédric Lecoutey; Sylvie Claeysen; Aurélie Malzert-Fréon; Thomas Freret; Michel Boulouard; Marc Since; Christophe Rochais; Patrick Dallemagne
Integrative in silico and experimental identification of non-covalent UBE2N inhibitors enhancing PARP inhibitor sensitivity

通过计算和实验相结合的方法鉴定能够增强PARP抑制剂敏感性的非共价UBE2N抑制剂

European Journal of Medicinal Chemistry Reports
IF4.1
2026-07-300
OAAI
Côme Ghadi; Shafi Ullah Khan; Léonie Ibazizene; Florian Schwalen; Charline Kieffer; Peggy Suzanne; Julie Jaouen; Hassiba Bouafia; Xavier Thuru; Marie Cornu; Cedric Lecoutey; Matthieu Meryet-Figuiere; Anne Sophie Voisin-Chiret; Louis-Bastien Weiswald; Jana Sopkova-de Oliveira Santos
An efficient step-by-step approach to select pleiotropic drug candidates against Alzheimer's disease: The discovery of neocopride

一种高效、分步筛选针对阿尔茨海默病的多效性药物候选物的方法：neocopride的发现

Journal of Alzheimer’s Disease
IF0
2026-03-130
PRE
Christophe Rochais; Cédric Lecoutey; Georgia Culley; Thomas Curel; Audrey Davis; Emilie Duval; Laura Rouvière; Alexandre Henriques; Romain Legrand; Sylvie Claeysen; Noëlle Callizot; Patrick Dallemagne
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Rochais, Christophe; Lecoutey, Cedric; Lalut, Julien; Davis, Audrey; Duval, Emilie; Gaven, Florence; Largilliere, Stacy; Nee, Gerald; Corvaisier, Sophie; Santos, Jana Sopkova de Oliveira; Since, Marc; Freret, Thomas; Legrand, Romain; Callizot, Noelle; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
NATURE COMMUNICATIONS
IF15.7
2024-05-161
OAAI
Mistretta, Maxime; Cimino, Mena; Campagne, Pascal; Volant, Stevenn; Kornobis, Etienne; Hebert, Olivier; Rochais, Christophe; Dallemagne, Patrick; Lecoutey, Cedric; Tisnerat, Camille; Lepailleur, Alban; Ayotte, Yann; LaPlante, Steven R.; Gangneux, Nicolas; Zahorszka, Monika; Kordulakova, Jana; Vichier-Guerre, Sophie; Bonhomme, Frederic; Pokorny, Laura; Albert, Marvin; Tinevez, Jean-Yves; Manina, Giulia
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease
FRONTIERS IN AGING NEUROSCIENCE
IF4.5
2019-06-1920
OAAI
Hatat, Berenice; Yahiaoui, Samir; Lecoutey, Cedric; Davis, Audrey; Freret, Thomas; Boulouard, Michel; Claeysen, Sylvie; Rochais, Christophe; Dallemagne, Patrick
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2019-01-0142
PREAI
Lalut, Julien; Santoni, Gianluca; Karila, Delphine; Lecoutey, Cedric; Davis, Audrey; Nachon, Florian; Silman, Israel; Sussman, Joel; Weik, Martin; Maurice, Tangui; Dallemagne, Patrick; Rochais, Christophe

研究方向

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P
Patrick Dallemagne
H 指数:32论文数:289被引数:4,098
C
Christophe Rochais
H 指数:25论文数:127被引数:2,498
S
Sylvie Claeysen
H 指数:36论文数:109被引数:4,228
A
Audrey Davis
H 指数:18论文数:43被引数:1,290
J
Jana Sopková‐de Oliveira Santos
H 指数:28论文数:222被引数:2,704
S
Sophie Corvaisier
H 指数:16论文数:63被引数:997
T
Thomas Fréret
H 指数:34论文数:200被引数:5,888
M
Marc Since
H 指数:17论文数:61被引数:826
M
Michel Boulouard
H 指数:35论文数:148被引数:5,230
R
Rémi Legay
H 指数:17论文数:125被引数:918