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M

Marc Since

Université de Caen Normandie
H指数:17
被引数:826

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Enhancing brain delivery of tegaserod for Alzheimer’s disease: a pharmaceutical comparison of two nanocarrier-based strategies

增强替加色罗在阿尔茨海默病中的脑内递送：两种基于纳米载体的策略的药物学比较

International Journal of Pharmaceutics
IF5.2
2026-07-150
OAAI
Line Séguy; Léna Guyon; Sophie Corvaisier; Manon Maurel; Pascal Verdié; Romuald Herbinet; Loïc Le Pluart; Lucie Dehouck; Emmanuel Sevin; Laurence Fenart; Fabien Gosselet; Stéphanie Lagadu; Gérald Née; Thomas Fréret; Marc Since; Raphaël Delépée; Patrick Dallemagne; Vincent Lisowski; Anne-Claire Groo; Aurélie Malzert-Fréon
Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer’s Disease

基于利伐斯明（Rivastigmine）的多效性前药的设计与评估：用于治疗阿尔茨海默病

ACS Chemical Neuroscience
IF3.9
2026-04-130
PRE
Valentin Travers-Lesage; Marc Since; Alice Wang; Audrey Davis; Dimitri Fayolle; Benoit Bernay; Fabrice Modeste; Florian Nachon; Xavier Brazzalotto; Lucie Crouzier; Jana Sopkova-De Oliveira Santos; Tangui Maurice; Patrick Dallemagne; Christophe Rochais
ID Card of Mcl-1 PROTAC degrader: From in silico design to biological validation in chemoresistant ovarian cancer

Mcl-1 PROTAC降解剂的ID Card：从计算机辅助设计到化疗耐药性卵巢癌中的生物验证

European Journal of Medicinal Chemistry Reports
IF4.1
2026-04-030
OAAI
Marie Cornu; Jocelyn Pezeril; Nicolas Guedeney; Hippolyte Paysant; Thomas Lemaitre; Florian Schwalen; Romane Florent; Julie N’Guyen; Sophie Corvaisier; Marc Since; Dimitri Fayolle; Amina Hamza; Mike Maillasson; Jana Sopkova-de Oliveira Santos; Charline Kieffer; Laurent Poulain; Anne Sophie Voisin-Chiret
Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

多官能化N-芳基磺酰基吲哚：用于表观遗传学基础治疗帕金森病的(E)-N-羟基-3-{3-[(5-(3-(哌啶-1-基)丙氧基)-1H-吲哚-1-基)磺酰基]苯基}丙烯酰胺（MTP150）的鉴定

International Journal of Molecular Sciences
IF4.9
2026-03-310
OAAI
Mireia Toledano-Pinedo; Alicia Porro-Pérez; Linda Schäker-Hübner; Daniel Diez-Iriepa; Isabel Iriepa; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroz-Płonka; Jadwiga Handzlik; Justyna Godyń; Patrick Dallemagne; Christophe Rochais; Audrey Davis; Marc Since; Belén Pérez; Aina Bellver-Sanchis; Alba Irisarri; Mercè Pallàs; Cristina Solana-Manrique; Francisco López-Muñoz; Lhassane Ismaili; Christian Griñán-Ferré; Nuria Paricio; Finn K. Hansen; Anna Więckowska; José Marco-Contelles
Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer’s disease model.

获得新型强效多效性前药，其靶向丁酰胆碱酯酶和血清素再摄取，并在阿尔茨海默病模型中具有抗遗忘活性。

European Journal of Medicinal Chemistry
IF5.9
2026-02-120
PRE
Valentin Travers--Lesage; Lucie Crouzier; Mirjana Antonijevic; Alice Wang; François-Xavier Toublet; Audrey Davis; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Marc Since; Tangui Maurice; Christophe Rochais; Patrick Dallemagne
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Rochais, Christophe; Lecoutey, Cedric; Lalut, Julien; Davis, Audrey; Duval, Emilie; Gaven, Florence; Largilliere, Stacy; Nee, Gerald; Corvaisier, Sophie; Santos, Jana Sopkova de Oliveira; Since, Marc; Freret, Thomas; Legrand, Romain; Callizot, Noelle; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick
Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-12-010
OAAI
Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Since, Marc; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent
Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2022-11-010
OAAI
Mustiere, Romain; Lagardere, Prisca; Hutter, Sebastien; Dell'Orco, Viviana; Amanzougaghene, Nadia; Tajeri, Shahin; Franetich, Jean-Francois; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Masurier, Nicolas; Lisowski, Vincent; Verhaeghe, Pierre; Mazier, Dominique; Azas, Nadine; Vanelle, Patrice; Primas, Nicolas
Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore
PHARMACEUTICALS
IF4.8
2022-08-135
OAAI
Paoli-Lombardo, Romain; Primas, Nicolas; Bourgeade-Delmas, Sandra; Hutter, Sebastien; Sournia-Saquet, Alix; Boudot, Clotilde; Brenot, Emilie; Castera-Ducros, Caroline; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Courtioux, Bertrand; Valentin, Alexis; Verhaeghe, Pierre; Azas, Nadine; Rathelot, Pascal; Vanelle, Patrice
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T.b. brucei hitcompound with improved pharmacokinetic properties
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2020-11-0113
OAAI
Fersing, Cyril; Boudot, Clotilde; Paoli-Lombardo, Romain; Primas, Nicolas; Pinault, Emilie; Hutter, Sebastien; Castera-Ducros, Caroline; Kabri, Youssef; Pedron, Julien; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Valentin, Alexis; Azqueta, Amaya; Muruzabal, Damian; Destere, Alexandre; Wyllie, Susan; Fairlamb, Alan H.; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Di Giorgio, Carole; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Vanelle, Patrice; Verhaeghe, Pierre

研究方向

暂未获取到该数据
S
Sophie Corvaisier
H 指数:16论文数:63被引数:997
P
Patrick Dallemagne
H 指数:32论文数:289被引数:4,098
A
Aurélie Malzert‐Fréon
H 指数:18论文数:65被引数:1,001
C
Christophe Rochais
H 指数:25论文数:127被引数:2,498
J
Jana Sopková‐de Oliveira Santos
H 指数:28论文数:222被引数:2,704
P
Pierre Verhaeghe
H 指数:39论文数:300被引数:4,849
A
Audrey Davis
H 指数:18论文数:43被引数:1,290
A
Anne Sophie Voisin‐Chiret
H 指数:22论文数:97被引数:1,644
T
Thomas Fréret
H 指数:34论文数:200被引数:5,888
C
Cédric Lecoutey
H 指数:16论文数:55被引数:699