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J

Jimmy Lu

University of Alberta
H指数:7
被引数:437

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Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design

结构洞察揭示了耐尼马特雷韦的SARS-CoV-2 Mpro L50F/E166A/L167F三重突变体-抑制剂复合物的策略，为下一代冠状病毒抑制剂设计提供了指导。

RSC Med. Chem.
IF3.6
2025-08-160
OAAI
Conrad Fischer; Jimmy Lu; Marco J. van Belkum; Sydney Demmon; Pu Chen; Chaoxiang Wang; Tayla J. Van Oers; Tess Lamer; M. Joanne Lemieux; John C. Vederas
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
ACS CENTRAL SCIENCE
IF10.4
2023-03-2124
OAAI
Chen, Sizhu Amelia; Arutyunova, Elena; Lu, Jimmy; Khan, Muhammad Bashir; Rut, Wioletta; Zmudzinski, Mikolaj; Shahbaz, Shima; Iyyathurai, Jegan; Moussa, Eman W.; Turner, Zoe; Bai, Bing; Lamer, Tess; Nieman, James A.; Vederas, John C.; Julien, Olivier; Drag, Marcin; Elahi, Shokrollah; Young, Howard S.; Lemieux, M. Joanne
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2021-10-0171
OAAI
Vuong, Wayne; Fischer, Conrad; Khan, Muhammad Bashir; van Belkum, Marco J.; Lamer, Tess; Willoughby, Kurtis D.; Lu, Jimmy; Arutyunova, Elena; Joyce, Michael A.; Saffran, Holly A.; Shields, Justin A.; Young, Howard S.; Nieman, James A.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Vederas, John C.
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-07-0975
PREAI
Bai, Bing; Belovodskiy, Alexandr; Hena, Mostofa; Kandadai, Appan Srinivas; Joyce, Michael A.; Saffran, Holly A.; Shields, Justin A.; Khan, Muhammad Bashir; Arutyunova, Elena; Lu, Jimmy; Bajwa, Sardeev K.; Hockman, Darren; Fischer, Conrad; Lamer, Tess; Vuong, Wayne; van Belkum, Marco J.; Gu, Zhengxian; Lin, Fusen; Du, Yanhua; Xu, Jia; Rahim, Mohammad; Young, Howard S.; Vederas, John C.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Nieman, James A.

研究方向

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J
John C. Vederas
H 指数:76论文数:524被引数:2.4万
T
Tess Lamer
H 指数:13论文数:29被引数:1,110
H
Howard S. Young
H 指数:45论文数:187被引数:5,242
E
Elena Arutyunova
H 指数:20论文数:59被引数:1,835
M
M. Joanne Lemieux
H 指数:41论文数:210被引数:5,635
M
Muhammad Bashir Khan
H 指数:17论文数:55被引数:1,380
J
James A. Nieman
H 指数:22论文数:53被引数:2,369
W
Wayne Vuong
H 指数:10论文数:15被引数:937
C
Conrad Fischer
H 指数:20论文数:75被引数:1,682
M
Michael Joyce
H 指数:38论文数:125被引数:5,653