Kouichi Yoshinari

University of Shizuoka

H指数:36

被引数:4,453

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Differences in reactive metabolite formation and cytochrome P450 binding between acetaminophen and its bicyclo[1.1.1]pentane bioisostere

乙酰氨基酚及其双环[1.1.1]戊烷生物电子等排体的反应性代谢物形成和细胞色素P450结合差异

Drug Metabolism and Pharmacokinetics

IF2.2

2026-04-150

PRE

Role of constitutive androstane receptor in developmental toxicology: linking chemical exposure, nutrition, and disease susceptibility

构成性雄烷受体在发育毒理学中的作用：连接化学暴露、营养和疾病易感性

Critical Reviews in Toxicology

IF4.1

2026-02-240

PRE

Read-across prediction of nongenotoxic thyroid carcinogenicity of pesticides in rats using mechanism-based in vitro assay data

基于机制基础的体外实验数据对大鼠农药非遗传毒性甲状腺致癌性的读跨预测

Food and Chemical Toxicology

IF3.5

2026-02-120

PRE

Chem–Bio Hybrid Synthesis Enables Reengineering of Natural Product-Based Methionine Aminopeptidase 2 Inhibitors for Treating Amebiasis

Chem-bio杂交合成使基于天然产物的蛋氨酸氨肽酶2抑制剂能够用于治疗阿米巴病

Journal of the American Chemical Society

IF15.6

2026-02-030

PRE

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide

环孢素与阿帕鲁amide在转移性激素敏感型前列腺癌患者中的持续性药物相互作用：病例报告及阿帕鲁amide通过孕烷X受体激活诱导CYP3A4的评估

Case Reports in Oncological Medicine

IF0.6

2026-01-010

OAAI

Cytochrome P450 inhibition correlates with hepatotoxicity of pesticides: Analysis using repeated-dose toxicity data in rats

细胞色素P450抑制与农药肝毒性相关：基于大鼠重复剂量毒性数据的分析

Drug Metabolism and Pharmacokinetics

IF2.2

2025-10-240

PRE

Investigating the Influence of Mucus Layer, Bile Acids, and Pharmaceutical Excipients on the Intestinal Permeability of Solifenacin Using PermeaPadTM Plate

使用PermeaPad™板探究黏液层、胆汁酸和药用辅料对索非那新肠道渗透性的影响

Journal of Pharmaceutical Sciences

IF3.8

2025-08-280

PRE

Construction of refined CYP2D6-Template system for studies of its metabolism and inhibition

构建精细的CYP2D6-Template系统以研究其代谢和抑制作用

Drug Metabolism and Pharmacokinetics

IF2.2

2025-07-020

PRE

Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates

药物诱导性心力衰竭与CYP1A1、CYP1B1和CYP3A4抑制之间的关联：细胞色素P450抑制测定法在评估药物候选物心脏毒性中的效用

Toxicology in Vitro

IF2.7

2025-05-300

PRE

Machine Learning on Toxicogenomic Data Reveals a Strong Association Between the Induction of Drug-Metabolizing Enzymes and Centrilobular Hepatocyte Hypertrophy in Rats

毒理学基因组学数据上的机器学习揭示了药物代谢酶诱导与大鼠中央小叶肝细胞肥大之间存在强关联

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-05-200

Contribution of Japanese scientists to drug metabolism and disposition

日本科学家对药物代谢和分布的贡献

DRUG METABOLISM AND DISPOSITION

IF4

2025-05-010

PRE

The refined CYP2B6-Template system for studies of its ligand metabolisms☆

优化的CYP2B6-Template系统用于研究其配体代谢☆

DRUG METABOLISM AND PHARMACOKINETICS

IF2.2

2025-02-010

PRE

Comprehensive analysis of the toxicity-related findings from repeated-dose subacute toxicity studies of industrial chemicals in male rats

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2024-12-050

Machine Learning-Based In Silico Prediction of the Inhibitory Activity of Chemical Substances Against Rat and Human Cytochrome P450s

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2024-10-200

OAAI

Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression

BIOCHEMICAL JOURNAL

IF4.3

2024-09-061

PRE

Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation

TOXICOLOGICAL SCIENCES

IF4.1

2023-12-214

PRE

Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays

TOXICOLOGY

IF4.6

2023-08-018

PRE

Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2022-12-013

PRE

Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells

EXPERIMENTAL CELL RESEARCH

IF3.5

2022-10-012

PRE

A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2022-01-0115

PRE

Kouichi Yoshinari

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