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J

Jadwiga Handzlik

jagiellonian university medical college
H指数:31
被引数:3,140

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Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

多官能化N-芳基磺酰基吲哚：用于表观遗传学基础治疗帕金森病的(E)-N-羟基-3-{3-[(5-(3-(哌啶-1-基)丙氧基)-1H-吲哚-1-基)磺酰基]苯基}丙烯酰胺（MTP150）的鉴定

International Journal of Molecular Sciences
IF4.9
2026-03-310
OAAI
Mireia Toledano-Pinedo; Alicia Porro-Pérez; Linda Schäker-Hübner; Daniel Diez-Iriepa; Isabel Iriepa; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroz-Płonka; Jadwiga Handzlik; Justyna Godyń; Patrick Dallemagne; Christophe Rochais; Audrey Davis; Marc Since; Belén Pérez; Aina Bellver-Sanchis; Alba Irisarri; Mercè Pallàs; Cristina Solana-Manrique; Francisco López-Muñoz; Lhassane Ismaili; Christian Griñán-Ferré; Nuria Paricio; Finn K. Hansen; Anna Więckowska; José Marco-Contelles
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment

第一类1,3,5-三嗪衍生的双5-HT6R/FAAH调节剂，用于寻找针对伴有认知障碍的神经退行性疾病的潜在药物

European Journal of Medicinal Chemistry
IF5.9
2025-08-050
OA
Kinga Czarnota-Łydka; Katarzyna Kucwaj-Brysz; Barbara Mordyl; Monika Głuch-Lutwin; Tadeusz Karcz; Magdalena Jastrzębska-Więsek; Anna Partyka; Monika Dąbrowska; Grzegorz Satała; Sylwia Sudoł-Tałaj; Leonardo Brunetti; Modesto de Candia; Rosa Purgatorio; Marco Cerini; Luca Piemontese; Sabina Podlewska; Gniewomir Latacz; Małgorzata Starek; Anna Wesołowska; Antonio Carrieri; Jadwiga Handzlik
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naive and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission

精神激素ibogaminalog和ibogainalog通过涉及5-HT2A受体激活和血清素能传递的机制在幼稚和抑郁小鼠中诱导抗抑郁样活性

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
IF3.9
2025-01-010
PRE
Arias, Hugo R.; Rudin, Deborah; Luethi, Dino; Valenta, Jan; Lesniak, Anna; Czartoryska, Zofia; Olejarz-Maciej, Agnieszka; Doroz-Plonka, Agata; Manetti, Dina; De Deurwaerdere, Philippe; Romanelli, Maria Novella; Handzlik, Jadwiga; Liechti, Matthias E.; Chagraoui, Abdeslam
Contilisant plus Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-100
PRE
Toledano-Pinedo, Mireia; Porro-Perez, Alicia; Schaeker-Huebner, Linda; Romero, Fernando; Dong, Min; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Bautista-Aguilera, Oscar M.; Rodriguez-Fernandez, M. Mercedes; Solana-Manrique, Cristina; Sanchis, Inmaculada; Mora-Morell, Alba; Rodriguez, Ania Canseco; Sanchez-Perez, Ana M.; Knez, Damijan; Gobec, Stanislav; Bellver-Sanchis, Aina; Perez, Belen; Dobrydnev, Alexey V.; Artetxe-Zurutuza, Aizpea; Matheu, Ander; Siwek, Agata; Wolak, Malgorzata; Satala, Grzegorz; Bojarski, Andrzej J.; Doroz-Plonka, Agata; Handzlik, Jadwiga; Godyn, Justyna; Wieckowska, Anna; Paricio, Nuria; Grinan-Ferre, Christian; Hansen, Finn K.; Marco-Contelles, Jose
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-089
OAAI
Pyka, Patryk; Haberek, Wawrzyniec; Wiecek, Malgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia; Di Sotto, Antonella; Garbo, Sabrina; Karcz, Tadeusz; Lambona, Chiara; Marocco, Francesco; Latacz, Gniewomir; Sudol-Talaj, Sylwia; Mordyl, Barbara; Gluch-Lutwin, Monika; Siwek, Agata; Czarnota-Lydka, Kinga; Gogola, Dawid; Olejarz-Maciej, Agnieszka; Wilczynska-Zawal, Natalia; Honkisz-Orzechowska, Ewelina; Starek, Malgorzata; Dabrowska, Monika; Kucwaj-Brysz, Katarzyna; Fioravanti, Rossella; Nasim, Muhammad Jawad; Hittinger, Marius; Partyka, Anna; Wesolowska, Anna; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-11-011
OAAI
Sudol-Talaj, Sylwia; Kucwaj-Brysz, Katarzyna; Podlewska, Sabina; Kurczab, Rafal; Satala, Grzegorz; Mordyl, Barbara; Gluch-Lutwin, Monika; Wilczynska-Zawal, Natalia; Jastrzebska-Wiesek, Magdalena; Czarnota-Lydka, Kinga; Kurowska, Kinga; Kubacka, Monika; Zeslawska, Ewa; Nitek, Wojciech; Olejarz-Maciej, Agnieszka; Doroz-Plonka, Agata; Partyka, Anna; Latacz, Gniewomir; Wesolowska, Anna; Handzlik, Jadwiga
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-11-018
OAAI
Czarnota-Lydka, Kinga; Sudol-Talaj, Sylwia; Kucwaj-Brysz, Katarzyna; Kurczab, Rafal; Satala, Grzegorz; de Candia, Modesto; Samarelli, Francesco; Altomare, Cosimo Damiano; Carocci, Alessia; Barbarossa, Alexia; Zeslawska, Ewa; Gluch-Lutwin, Monika; Mordyl, Barbara; Kubacka, Monika; Wilczynska-Zawal, Natalia; Jastrzebska-Wiesek, Magdalena; Partyka, Anna; Khan, Nadia; Wiecek, Malgorzata; Nitek, Wojciech; Honkisz-Orzechowska, Ewelina; Latacz, Gniewomir; Wesolowska, Anna; Carrieri, Antonio; Handzlik, Jadwiga
Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents-Design, synthesis, structural studies and pharmacological profiling
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-04-014
PRE
Stepnicki, Piotr; Targowska-Duda, Katarzyna M.; Martinez, Anton L.; Zieba, Agata; Wronikowska-Denysiuk, Olga; Wrobel, Martyna Z.; Bartyzel, Agata; Trzpil, Alicja; Wrobel, Tomasz M.; Chodkowski, Andrzej; Mirecka, Karolina; Karcz, Tadeusz; Szczepanska, Katarzyna; Loza, Maria I.; Budzynska, Barbara; Turlo, Jadwiga; Handzlik, Jadwiga; Fornal, Emilia; Poleszak, Ewa; Castro, Marian; Kaczor, Agnieszka A.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease
MOLECULES
IF4.6
2022-12-285
OAAI
Godyn, Justyna; Zareba, Paula; Stary, Dorota; Kaleta, Maria; Kuder, Kamil J.; Latacz, Gniewomir; Mogilski, Szczepan; Reiner-Link, David; Frank, Annika; Doroz-Plonka, Agata; Olejarz-Maciej, Agnieszka; Sudol-Talaj, Sylwia; Nolte, Tobias; Handzlik, Jadwiga; Stark, Holger; Wieckowska, Anna; Malawska, Barbara; Kiec-Kononowicz, Katarzyna; Lazewska, Dorota; Bajda, Marek

研究方向

暂未获取到该数据
K
Katarzyna Kieć‐Kononowicz
H 指数:39论文数:400被引数:6,057
G
Gniewomir Latacz
H 指数:27论文数:194被引数:2,369
G
Grzegorz Satała
H 指数:29论文数:202被引数:2,693
K
Katarzyna Kucwaj‐Brysz
H 指数:14论文数:52被引数:555
A
Anna Wesołowska
H 指数:33论文数:201被引数:3,836
E
Ewa Szymańska
H 指数:27论文数:146被引数:3,570
A
Anna Partyka
H 指数:29论文数:162被引数:2,382
A
Agata Siwek
H 指数:33论文数:283被引数:4,345
W
Wojciech Nitek
H 指数:27论文数:383被引数:2,397
D
Dorota Łażewska
H 指数:27论文数:126被引数:1,826