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N

Nicky J. Willis

university college london
H指数:14
被引数:1,189

个人简介

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教育背景

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工作经历

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荣誉奖项

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Structural Analysis and Development of Notum Fragment Screening Hits
ACS CHEMICAL NEUROSCIENCE
IF3.9
2022-06-224
OAAI
Zhao, Yuguang; Mahy, William; Willis, Nicky J.; Woodward, Hannah L.; Steadman, David; Bayle, Elliott D.; Atkinson, Benjamin N.; Sipthorp, James; Vecchia, Luca; Ruza, Reinis R.; Harlos, Karl; Jeganathan, Fiona; Constantinou, Stefan; Costa, Artur; Kjaer, Svend; Bictash, Magda; Salinas, Patricia C.; Whiting, Paul; Vincent, Jean-Paul; Fish, Paul, V; Jones, E. Yvonne
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-05-1010
OAAI
Willis, Nicky J.; Mahy, William; Sipthorp, James; Zhao, Yuguang; Woodward, Hannah L.; Atkinson, Benjamin N.; Bayle, Elliott D.; Svensson, Fredrik; Frew, Sarah; Jeganathan, Fiona; Monaghan, Amy; Benvegnu, Stefano; Jolly, Sarah; Vecchia, Luca; Ruza, Reinis R.; Kjaer, Svend; Howell, Steven; Snijders, Ambrosius P.; Bictash, Magda; Salinas, Patricia C.; Vincent, Jean-Paul; Jones, E. Yvonne; Whiting, Paul; Fish, Paul, V
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

4，6-二苯基嘧啶-2-碳酰肼作为促性腺激素调节剂治疗杜氏肌营养不良的发现和作用机制研究

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2021-08-019
PREAI
Vuorinen, Aini; Wilkinson, Isabel V. L.; Chatzopoulou, Maria; Edwards, Ben; Squire, Sarah E.; Fairclough, Rebecca J.; Bazan, Noelia Araujo; Milner, Josh A.; Conole, Daniel; Donald, James R.; Shah, Nandini; Willis, Nicky J.; Martinez, R. Fernando; Wilson, Francis X.; Wynne, Graham M.; Davies, Stephen G.; Davies, Kay E.; Russell, Angela J.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

来自Apc突变细胞的NOTUM偏向克隆竞争引发癌症

Nature
IF48.5
2021-06-020
PREAI
Dustin J. Flanagan; Nalle Pentinmikko; Kalle Luopajärvi; Nicky J. Willis; Kathryn Gilroy; Alexander P. Raven; Lynn Mcgarry; Johanna I. Englund; Anna T. Webb; Sandra Scharaw; Nadia Nasreddin; Michael C. Hodder; Rachel A. Ridgway; Emma Minnee; Nathalie Sphyris; Ella Gilchrist; Arafath K. Najumudeen; Beatrice Romagnolo; Christine Perret; Ann C. Williams; Hans Clevers; Pirjo Nummela; Marianne Lähde; Kari Alitalo; Ville Hietakangas; Ann Hedley; William Clark; Colin Nixon; Kristina Kirschner; E. Yvonne Jones; Ari Ristimäki; Simon J. Leedham; Paul V. Fish; Jean-Paul Vincent; Pekka Katajisto; Owen J. Sansom
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni
ACS INFECTIOUS DISEASES
IF3.8
2021-04-028
OAAI
Partridge, Frederick A.; Bataille, Carole J. R.; Forman, Ruth; Marriott, Amy E.; Forde-Thomas, Josephine; Haeberli, Cecile; Dinsdale, Ria L.; O'Sullivan, James D. B.; Willis, Nicky J.; Wynne, Graham M.; Whiteland, Helen; Archer, John; Steven, Andrew; Keiser, Jennifer; Turner, Joseph D.; Hoffmann, Karl F.; Taylor, Mark J.; Else, Kathryn J.; Russell, Angela J.; Sattelle, David B.
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-10-3015
OAAI
Mahy, William; Willis, Nicky J.; Zhao, Yuguang; Woodward, Hannah L.; Svensson, Fredrik; Sipthorp, James; Vecchia, Luca; Ruza, Reinis R.; Hillier, James; Kjaer, Svend; Frew, Sarah; Monaghan, Amy; Bictash, Magda; Salinas, Patricia C.; Whiting, Paul; Vincent, Jean-Paul; Jones, E. Yvonne; Fish, Paul, V
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-07-2917
OAAI
Mahy, William; Patel, Mikesh; Steadman, David; Woodward, Hannah L.; Atkinson, Benjamin N.; Svensson, Fredrik; Willis, Nicky J.; Flint, Alister; Papatheodorou, Dimitra; Zhao, Yuguang; Vecchia, Luca; Ruza, Reinis R.; Hillier, James; Frew, Sarah; Monaghan, Amy; Costa, Artur; Bictash, Magda; Walter, Magnus W.; Jones, E. Yvonne; Fish, Paul V.
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-10-1010
OAAI
Chatzopoulou, Maria; Claridge, Tim D. W.; Davies, Kay E.; Davies, Stephen G.; Elsey, David J.; Emer, Enrico; Fletcher, Ai M.; Harriman, Shawn; Robinson, Neil; Rowley, Jessica A.; Russell, Angela J.; Tinsley, Jonathon M.; Weaver, Richard; Wilkinson, Isabel V. L.; Willis, Nicky J.; Wilson, Francis X.; Wynne, Graham M.
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

用于线虫和寄生线虫化学文库表型筛选的自动化高通量系统

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
IF3.4
2018-04-0161
OAAI
Partridge, Frederick A.; Brown, Anwen E.; Buckingham, Steven D.; Willis, Nicky J.; Wynne, Graham M.; Forman, Ruth; Else, Kathryn J.; Morrison, Alison A.; Matthews, Jacqueline B.; Russell, Angela J.; Lomas, David A.; Sattelle, David B.
Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation (vol 1837, pg 811, 2014)
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
IF2.7
2018-02-012
PREAI
Llorente-Garcia, Isabel; Lenn, Tchern; Erhardt, Heiko; Harriman, Oliver L.; Liu, Lu-Ning; Robson, Alex; Chiu, Sheng-Wen; Matthews, Sarah; Willis, Nicky J.; Bray, Christopher D.; Lee, Sang-Hyuk; Shin, Jae Yen; Bustarnante, Carlos; Liphardt, Jan; Friedrich, Thorsten; Mullineaux, Conrad W.; Leake, Mark C.

研究方向

暂未获取到该数据
A
Angela J. Russell
H 指数:46论文数:348被引数:5,960
G
Graham M. Wynne
H 指数:20论文数:78被引数:1,255
P
Paul V. Fish
H 指数:27论文数:107被引数:4,694
F
Fredrik Svensson
H 指数:24论文数:131被引数:2,080
B
Benjamin N. Atkinson
H 指数:12论文数:29被引数:646
E
E. Yvonne Jones
H 指数:105论文数:600被引数:3.2万
J
Jean‐Paul Vincent
H 指数:46论文数:136被引数:6,694
Y
Yuguang Zhao
H 指数:43论文数:141被引数:1.0万
H
Hannah L. Woodward
H 指数:16论文数:55被引数:660
M
Magda Bictash
H 指数:19论文数:40被引数:3,865