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N

Najma Rachidi

institut pasteur and inserm
H指数:21
被引数:1,873

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Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1; 2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

以药效团为指导对靶向酪蛋白激酶1的抗利什曼原虫治疗中具有潜力的咪唑并[1; 2-a]吡嗪衍生物进行先导化合物CTN1122的优化设计

RSC Med. Chem.
IF3.6
2025-08-140
PRE
Lhana Tisseur; Cédric Logé; Sandrine Cojean; Khadidiatou Gassama; Lilian Karcher; Fabrice Pagniez; Christian Cavé; Guillaume Bernadat; Philippe M. Loiseau; Stéphane Bach; Jérôme Thiéfaine; Justine Bonnet; Carine Picot; Christophe Tomasoni; Olivier Leclercq; Blandine Baratte; Thomas Robert; Patrice Le Pape; Najma Rachidi; Marc-Antoine Bazin; Pascal Marchand
Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

研究基于咪唑并 [1，2-a] 吡嗪的命中化合物CTN1122的C2调节: 合成，体外抗利什曼蛋白活性，细胞毒性和酪蛋白激酶1抑制

CHEMMEDCHEM
IF3.4
2025-01-060
PRE
Tisseur, Lhana; Cojean, Sandrine; Gassama, Khadidiatou; Loge, Cedric; Pagniez, Fabrice; Cave, Christian; Bernadat, Guillaume; Loiseau, Philippe M.; Bach, Stephane; Thiefaine, Jerome; Picot, Carine; Tomasoni, Christophe; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Le Pape, Patrice; Rachidi, Najma; Bazin, Marc-Antoine; Marchand, Pascal
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2021-01-0117
OAAI
Bazin, Marc-Antoine; Cojean, Sandrine; Pagniez, Fabrice; Bernadat, Guillaume; Cave, Christian; Ourliac-Garnier, Isabelle; Nourrisson, Marie-Renee; Morgado, Cathy; Picot, Carine; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Spath, Gerald F.; Rachidi, Najma; Bach, Stephane; Loiseau, Philippe M.; Le Pape, Patrice; Marchand, Pascal
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2016-05-0141
OAAI
Durieu, Emilie; Prina, Eric; Leclercq, Olivier; Oumata, Nassima; Gaboriaud-Kolar, Nicolas; Vougogiannopoulou, Konstantina; Aulner, Nathalie; Defontaine, Audrey; No, Joo Hwan; Ruchaud, Sandrine; Skaltsounis, Alexios-Leandros; Galons, Herve; Spaeth, Gerald F.; Meijer, Laurent; Rachidi, Najma

研究方向

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L
L Olivier
H 指数:12论文数:63被引数:484
P
Patrice Le Pape
H 指数:38论文数:224被引数:4,551
F
Fabrice Pagniez
H 指数:20论文数:64被引数:1,218
M
Marc‐Antoine Bazin
H 指数:14论文数:40被引数:646
G
Gerald Frank Spaeth
H 指数:4论文数:12被引数:290
G
Gérald F. Späth
H 指数:41论文数:186被引数:6,142
C
Carine Picot
H 指数:13论文数:39被引数:494
P
Philippe M. Loiseau
H 指数:48论文数:376被引数:9,078
S
Sandrine Cojean
H 指数:24论文数:102被引数:1,583
S
Stéphane Bach
H 指数:30论文数:219被引数:3,203