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L

L Olivier

institut pasteur and inserm
H指数:12
被引数:484

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Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1; 2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

以药效团为指导对靶向酪蛋白激酶1的抗利什曼原虫治疗中具有潜力的咪唑并[1; 2-a]吡嗪衍生物进行先导化合物CTN1122的优化设计

RSC Med. Chem.
IF3.6
2025-08-140
PRE
Lhana Tisseur; Cédric Logé; Sandrine Cojean; Khadidiatou Gassama; Lilian Karcher; Fabrice Pagniez; Christian Cavé; Guillaume Bernadat; Philippe M. Loiseau; Stéphane Bach; Jérôme Thiéfaine; Justine Bonnet; Carine Picot; Christophe Tomasoni; Olivier Leclercq; Blandine Baratte; Thomas Robert; Patrice Le Pape; Najma Rachidi; Marc-Antoine Bazin; Pascal Marchand
Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

研究基于咪唑并 [1，2-a] 吡嗪的命中化合物CTN1122的C2调节: 合成，体外抗利什曼蛋白活性，细胞毒性和酪蛋白激酶1抑制

CHEMMEDCHEM
IF3.4
2025-01-060
PRE
Tisseur, Lhana; Cojean, Sandrine; Gassama, Khadidiatou; Loge, Cedric; Pagniez, Fabrice; Cave, Christian; Bernadat, Guillaume; Loiseau, Philippe M.; Bach, Stephane; Thiefaine, Jerome; Picot, Carine; Tomasoni, Christophe; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Le Pape, Patrice; Rachidi, Najma; Bazin, Marc-Antoine; Marchand, Pascal
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2021-01-0117
OAAI
Bazin, Marc-Antoine; Cojean, Sandrine; Pagniez, Fabrice; Bernadat, Guillaume; Cave, Christian; Ourliac-Garnier, Isabelle; Nourrisson, Marie-Renee; Morgado, Cathy; Picot, Carine; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Spath, Gerald F.; Rachidi, Najma; Bach, Stephane; Loiseau, Philippe M.; Le Pape, Patrice; Marchand, Pascal
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2016-05-0141
OAAI
Durieu, Emilie; Prina, Eric; Leclercq, Olivier; Oumata, Nassima; Gaboriaud-Kolar, Nicolas; Vougogiannopoulou, Konstantina; Aulner, Nathalie; Defontaine, Audrey; No, Joo Hwan; Ruchaud, Sandrine; Skaltsounis, Alexios-Leandros; Galons, Herve; Spaeth, Gerald F.; Meijer, Laurent; Rachidi, Najma
Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

环孢菌素A治疗多氏利什曼原虫揭示了亲环蛋白在寄生虫增殖和生存中的特定阶段功能

PLOS NEGLECTED TROPICAL DISEASES
IF3.4
2010-06-2933
OAAI
Yau, Wai-Lok; Blisnick, Thierry; Taly, Jean-Francois; Helmer-Citterich, Manuela; Schiene-Fischer, Cordelia; Leclercq, Olivier; Li, Jing; Schmidt-Arras, Dirk; Morales, Miguel A.; Notredame, Cedric; Romo, Daniel; Bastin, Philippe; Spaeth, Gerald F.

研究方向

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N
Najma Rachidi
H 指数:21论文数:41被引数:1,873
G
Gerald Frank Spaeth
H 指数:4论文数:12被引数:290
P
Philippe M. Loiseau
H 指数:48论文数:376被引数:9,080
S
Sandrine Cojean
H 指数:24论文数:102被引数:1,583
S
Stéphane Bach
H 指数:30论文数:219被引数:3,203
G
Guillaume Bernadat
H 指数:23论文数:98被引数:1,599
P
Patrice Le Pape
H 指数:38论文数:224被引数:4,552
T
Thomas Robert
H 指数:32论文数:168被引数:3,478
F
Fabrice Pagniez
H 指数:20论文数:64被引数:1,218
B
Blandine Baratte
H 指数:22论文数:114被引数:1,788