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H

Hamed W. El-Shafey

Mansoura University
H指数:8
被引数:232

个人简介

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Design, synthesis, and molecular modeling of quinoline-linked diphenylpyrazoles as multitarget EGFR, VEGFR-2, and COX-2 inhibitors with anticancer, anti-inflammatory and apoptosis-inducing properties

喹啉连接的二苯基吡唑类化合物的设计、合成与分子模拟：作为多靶点EGFR、VEGFR-2和COX-2抑制剂，具有抗癌、抗炎和诱导凋亡的活性

Bioorganic Chemistry
IF4.7
2026-09-240
PRE
Abdelrahman Hamdi; Mohamed R. Elnagar; Maha Salih Hussein; Nahed Nasser Eid El-Sayed; Marwa I. Serag; Adel S. El-Azab; Simone Brogi; Hazem A. Ghabbour; Nareman A. Nawareg; Hamed W. El-Shafey; Alaa A.-M. Abdel-Aziz
Discovery of thieno[2; 3-d]pyrimidine-based dual Aurora B/VEGFR-2 inhibitors with potent anticancer activity: molecular docking; mechanistic studies; and in vivo validation in a breast cancer model

噻吩并[2; 3-d]嘧啶类双 Aurora B/VEGFR-2 抑制剂的发现：具有强抗癌活性的分子对接、机理研究和乳腺癌模型中的体内验证

rsc adv.
IF0
2026-04-220
OA
Hamed W. El-Shafey; Abdelrahman Hamdi; Mohamed R. Elnagar; Sahar M. Gebril; Abdullah Haikal; Adel S. El-Azab; Simone Brogi; Ibrahim A. Al-Suwaidan; Alaa A.-M. Abdel-Aziz
Quinazoline-sulfonamide hybrids as multitarget anticancer agents: inhibition of carbonic anhydrase IX/XII isoforms and VEGFR-2 with in vitro and in silico validation

喹唑啉-磺酰胺杂合物作为多靶点抗癌药物：对碳酸酐酶IX/XII异构体和VEGFR-2的抑制及体外与计算机模拟验证

Molecular Diversity
IF3.8
2026-04-190
PRE
Mohamed A. Zeidan; Mohammad M. Al-Sanea; Mohamed R. Elnagar; Mohamed M. Tawfik; Hamed W. El-Shafey; Samar S. Tawfik; Simone Brogi; Abdelrahman Hamdi
Click chemistry synthesis of triazole-grafted quinazolinones as new multi-panel anticancer agents: mechanistic insights into apoptosis and cell cycle arrest in colorectal cancer

三唑基喹唑啉酮的点击化学合成及其作为新型多靶点抗癌药物的应用：对结直肠癌中凋亡机制和细胞周期阻滞的机制洞察

Bioorganic Chemistry
IF4.7
2026-04-070
PRE
Mohammad M. Al-Sanea; Mohamed R. Elnagar; Hamed W. El-Shafey; Marwa I. Serag; Nimah Saad Alanzi; Mahmoud S. Elkotamy; Rofaida Salem; Wagdy M. Eldehna; Abdelrahman Hamdi
Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
IF5.4
2023-07-2012
OAAI
Hamdi, Abdelrahman; Yaseen, Muhammad; Ewes, Wafaa A. A.; Bhat, Mashooq Ahmad; Ziedan, Noha I. I.; El-Shafey, Hamed W. W.; Mohamed, Ahmed A. B.; Elnagar, Mohamed R. R.; Haikal, Abdullah; Othman, Dina I. A.; Elgazar, Abdullah A. A.; Abusabaa, Ahmed H. A.; Abdelrahman, Kamal S. S.; Soltan, Osama M. M.; Elbadawi, Mostafa M. M.

研究方向

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A
Abdelrahman Hamdi
H 指数:14论文数:45被引数:507
A
Abdullah A. Elgazar
H 指数:19论文数:40被引数:818
M
Mohamed R. Elnagar
H 指数:13论文数:52被引数:617
M
Mohammad M. Al‐Sanea
H 指数:32论文数:139被引数:3,154
A
Abdullah Haikal
H 指数:10论文数:34被引数:214
S
Simone Brogi
H 指数:42论文数:209被引数:5,297
A
Ahmed A. B. Mohamed
H 指数:12论文数:36被引数:382
M
M. A. Bhat
H 指数:47论文数:355被引数:8,067
A
Alaa A.‐M. Abdel‐Aziz
H 指数:44论文数:212被引数:5,145
A
Adel S. El‐Azab
H 指数:40论文数:204被引数:4,459