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Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non-zinc binding mode 基于DNA编码库筛选的自主生长因子抑制剂先导化合物的优化，获得了一种具有非锌结合模式的强效体内溶血磷脂酸降低的喹唑啉酮类化合物。 Martin, Rainer E.; Satz, Alexander L.; Kuratli, Christoph; Hunziker, Daniel; Mattei, Patrizio; Hert, Jerome; Ullmer, Christoph; Rudolph, Markus G.; Alker, Andre M.; Hochstrasser, Remo; Marx, Andreas; Binder, Martin; Muller, Stephan 分享 收藏
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Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry Atz, Kenneth; Nippa, David F.; Mueller, Alex T.; Jost, Vera; Anelli, Andrea; Reutlinger, Michael; Kramer, Christian; Martin, Rainer E.; Grether, Uwe; Schneider, Gisbert; Wuitschik, Georg 分享 收藏
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening Nippa, David F.; Atz, Kenneth; Mueller, Alex T.; Wolfard, Jens; Isert, Clemens; Binder, Martin; Scheidegger, Oliver; Konrad, David B.; Grether, Uwe; Martin, Rainer E.; Schneider, Gisbert 分享 收藏
Development and Demonstration of a High-Volume Manufacturing Process for a Key Intermediate of Dalcetrapib: Investigations on the Alkylation of Carboxylic Acids, Esters, and Nitriles Harnett, Gerard J.; Hauck, Ulrike; Hayes, John J.; Hoffmann, Ursula; Lohri, Bruno; Meade, Michael; Morawitz, Falk; Plesniak, Mateusz P.; Stahr, Helmut; Veits, Joachim; Walsh, Andrew; Zogg, Andreas; Reents, Reinhard; Smith, Dennis A.; Martin, Rainer E. 分享 收藏
Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties Sela, Tatjana; Manso, Mads; Siegel, Michel; Marban-Doran, Celine; Ducret, Axel; Niewoehner, Jens; Ravn, Jacob; Martin, Rainer E.; Sommer, Annika; Lohmann, Sabine; Krippendorff, Ben-Fillippo; Ladefoged, Mette; Indlekofer, Annette; Quaiser, Tom; Bueddefeld, Florian; Koller, Erich; Mohamed, Mohamed Y.; Oelschlaegel, Tobias; Gothelf, Kurt V.; Hofer, Kerstin; Schumacher, Felix F. 分享 收藏
Rapid 18F- and 19F-Difluoromethylation through Desulfurative Fluorination of Transient N-, O-, and C-Linked Dithioles 通过瞬时N-，O-和C-连接的二硫醇的脱硫氟化作用快速进行18F-和19f-二氟甲基化 Newton, Josiah J.; Engudar, Gokce; Brooke, Alan J.; Nodwell, Matthew B.; Horngren-Rhodes, Holly; Martin, Rainer E.; Schaffer, Paul; Britton, Robert; Friesen, Chadron M. 分享 收藏
Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner Jepsen, Sara L.; Albrechtsen, Nicolai J. Wewer; Windelov, Johanne Agerlin; Galsgaard, Katrine D.; Hunt, Jenna Elizabeth; Farb, Thomas B.; Kissow, Hannelouise; Pedersen, Jens; Deacon, Carolyn F.; Martin, Rainer E.; Holst, Jens J. 分享 收藏
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Electrostatic Effects Accelerate Decatungstate-Catalyzed C-H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics Yuan, Zheliang; Yang, Hua; Malik, Noeen; Colovic, Milena; Weber, David S.; Wilson, Darryl; Benard, Francois; Martin, Rainer E.; Warren, Jeffrey J.; Schaffer, Paul; Britton, Robert 分享 收藏
18F-Branched-Chain Amino Acids: Structure-Activity Relationships and PET Imaging Potential Nodwell, Matthew B.; Yang, Hua; Merkens, Helen; Malik, Noeen; Colovic, Milena; Wagner, Bjorn; Martin, Rainer E.; Benard, Francxois; Schaffer, Paul; Britton, Robert 分享 收藏
2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design Giroud, Maude; Kuhn, Bernd; Saint-Auret, Sarah; Kuratli, Christoph; Martin, Rainer E.; Schuler, Franz; Diederich, Francois; Kaiser, Marcel; Brun, Reto; Schirmeister, Tanja; Haap, Wolfgang 分享 收藏
Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives Meanwell, Michael; Adluri, Bharani Shashank; Yuan, Zheliang; Newton, Josiah; Prevost, Philippe; Nodwell, Matthew B.; Friesen, Chadron M.; Schaffer, Paul; Martin, Rainer E.; Britton, Robert 分享 收藏
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Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors Kuhn, Bernd; Tichy, Michal; Wang, Lingle; Robinson, Shaughnessy; Martin, Rainer E.; Kuglstatter, Andreas; Benz, Jorg; Giroud, Maude; Schirmeister, Tanja; Abel, Robert; Diederich, Francois; Hert, Jerome 分享 收藏
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