Kim L. R. Brouwer - Publications, H-index & Citations

Kim L. R. Brouwer

university of north carolina

61H指数

377论文数

1.6W被引数

收录论文 122

发表时间

Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters 评估人类3D多细胞肝球体模型作为研究肝转运蛋白平台的可行性

Cellular and Molecular Life Sciences

IF6.2

2025-12-30

OAAI

Mattie Hartauer; Henry Ho; Meimei Wan; William A. Murphy; Jacqueline B. Tiley; John K. Fallon; Colin E. Bishop; Kim L. R. Brouwer

Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure 纳入胎盘转运的二甲双胍PBPK模型比较，以预测胎儿和母体暴露

CPT: Pharmacometrics & Systems Pharmacology

IF0

2025-11-25

OAAI

Jacqueline B. Tiley; Mattie E. Hartauer; Tajhia L. Whigham; Maïlys De Sousa Mendes; Kim L. R. Brouwer; Mary F. Hebert

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model 肥胖和MASH对区带肝细胞他汀暴露的影响：来自渗透性限制的多隔室肝脏模型的药效学见解

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2025-11-01

OAAI

Murphy, William A.; Sjostedt, Noora; Mendes, Mailys De Sousa; Hartauer, Mattie; Brouwer, Kim L. R.; Neuhoff, Sibylle

Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria 理解粪卟啉及其代谢途径：粪卟啉尿常见，原因多样，且很少提示卟啉症

The American Journal of Medicine

IF0

2025-04-12

PREAI

Herbert L. Bonkovsky; Christopher D. Ma; Manuela Araque; Jacqueline B. Tiley; Kim L.R. Brouwer; Ulrich Stölzel

Visualizing Sodium/Taurocholate Cotransporting Polypeptide (NTCP) Activity and Localization using Optogenetic Tools 利用光遗传学工具可视化钠/牛磺胆酸共转运肽(NTCP)的活性和定位

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-03-01

PREAI

Upadhye, Mihir; Tiley, Jacqueline; Brouwer, Kim; Haar, Lauren

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo (vol 16, 1906360, 2020)纳米颗粒药物递送可降低治疗性载体的肝毒性 (vol 16, 1906360, 2020)

SMALL

IF12.1

2025-01-10

PREAI

Yang, Feifei; Medik, Yusra; Li, Liantao; Tian, Xi; Fu, Dong; Brouwer, Kim L. R.; Wangner, Kyle; Sun, Bo; Sendi, Hossein; Mi, Yu; Wang, Andrew Z.

Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2024-09-24

PREAI

Tiley, Jacqueline B.; Beaudoin, James J.; Derebail, Vimal K.; Murphy, William A.; Park, Christine C.; Veeder, Justin A.; Tran, Lana; Beers, Jessica L.; Jia, Wei; Stewart, Paul W.; Brouwer, Kim L. R.

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-06-19

OAAI

Hartauer, Mattie; Murphy, William A.; Brouwer, Kim L. R.; Southall, Roz; Neuhoff, Sibylle

Effects of PFAS on human liver transporters: implications for health outcomes

TOXICOLOGICAL SCIENCES

IF4.1

2024-05-09

OAAI

Vujic, Ena; Ferguson, Stephen S.; Brouwer, Kim L. R.

Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD NAFLD患者肝细胞胆汁酸转运蛋白的区域分布和质膜定位的变化

HEPATOLOGY COMMUNICATIONS

IF4.6

2024-03-01

OAAI

Murphy, William A.; Diehl, Anna Mae; Loop, Matthew Shane; Fu, Dong; Guy, Cynthia D.; Abdelmalek, Manal F.; Karachaliou, Georgia Sofia; Sjostedt, Noora; Neuhoff, Sibylle; Honkakoski, Paavo; Brouwer, Kim L. R.

Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

PHARMACEUTICAL RESEARCH

IF4.3

2024-02-13

PREAI

Adiwidjaja, Jeffry; Spires, Jessica; Brouwer, Kim L. R.

Membrane transporters in drug development and as determinants of precision medicine 药物开发中的膜转运蛋白和精准医学的决定因素

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2024-01-24

PREAI

Galetin, Aleksandra; Brouwer, Kim L. R.; Tweedie, Donald; Yoshida, Kenta; Sjostedt, Noora; Aleksunes, Lauren; Chu, Xiaoyan; Evers, Raymond; Hafey, Michael J.; Lai, Yurong; Matsson, Par; Riselli, Andrew; Shen, Hong; Sparreboom, Alex; Varma, Manthena V. S.; Yang, Jia; Yang, Xinning; Yee, Sook Wah; Zamek-Gliszczynski, Maciej J.; Zhang, Lei; Giacomini, Kathleen M.

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

PHARMACEUTICAL RESEARCH

IF4.3

2023-06-22

PREAI

Jeong, Angela; Pastor, Catherine M.; Brouwer, Kim L. R.

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity 一种新的分化HuH-7细胞模型，用于检查胆汁酸代谢，运输和胆汁淤积性肝毒性

SCIENTIFIC REPORTS

IF3.9

2022-08-22

OAAI

Saran, Chitra; Fu, Dong; Ho, Henry; Klein, Abigail; Fallon, John K.; Honkakoski, Paavo; Brouwer, Kim L. R.

Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2022-06-22

OAAI

Taskar, Kunal S.; Yang, Xinning; Neuhoff, Sibylle; Patel, Mitesh; Yoshida, Kenta; Paine, Mary F.; Brouwer, Kim L. R.; Chu, Xiaoyan; Sugiyama, Yuichi; Cook, Jack; Polli, Joseph W.; Hanna, Imad; Lai, Yurong; Zamek-Gliszczynski, Maciej

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2022-06-02

OAAI

Murphy, William A.; Adiwidjaja, Jeffry; Sjostedt, Noora; Yang, Kyunghee; Beaudoin, James J.; Spires, Jessica; Siler, Scott Q.; Neuhoff, Sibylle; Brouwer, Kim L. R.

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium 药物转运蛋白的调控-从机制到临床影响: 代表国际转运蛋白联盟的白皮书

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2022-05-24

OAAI

Brouwer, Kim L. R.; Evers, Raymond; Hayden, Elizabeth; Hu, Shuiying; Li, Cindy Yanfei; zu Schwabedissen, Henriette E. Meyer; Neuhoff, Sibylle; Oswald, Stefan; Piquette-Miller, Micheline; Saran, Chitra; Sjostedt, Noora; Sprowl, Jason A.; Stahl, Simone H.; Yue, Wei

Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes

FEBS LETTERS

IF3

2022-02-28

OAAI

Kralj, Thomas; Khatri, Raju; Brouwer, Kenneth R.; Brouwer, Kim L. R.; Creek, Darren J.

Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors 与酪氨酸激酶抑制剂相关的新型胆汁酸依赖性肝毒性机制

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2022-02-01

OAAI

Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim L. R.

Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β)影响有机溶质转运蛋白 α/β (OSTα/β) 的关键氨基酸的鉴定

MOLECULAR PHARMACOLOGY

IF3

2021-12-01

OAAI

Murphy, William A.; Beaudoin, James J.; Laitinen, Tuomo; Sjostedt, Noora; Malinen, Melina M.; Ho, Henry; Swaan, Peter W.; Honkakoski, Paavo; Brouwer, Kim L. R.

研究方向