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Differential regulation of BAX and BAK apoptotic activity revealed by small molecules 通过小分子揭示BAX和BAK凋亡活性的差异性调控 Li, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F. 分享 收藏
Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors 亚氨基嘧啶酮稠合的吡咯烷的结构活性分析有助于双重plasmepsin V和plasmepsin X抑制剂的开发 Hodder, Anthony N.; Sleebs, Brad E.; Adams, Greg; Rezazadeh, Sina; Ngo, Anna; Jarman, Kate; Scally, Stephen; Czabotar, Peter; Wang, Hongwu; Mccauley, John A.; Olsen, David B.; Cowman, Alan F. 分享 收藏
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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells Satish, Hema Preethi Subas; Iyer, Sweta; Shi, Melissa X.; Wong, Agnes W.; Fischer, Karla C.; Wardak, Ahmad Z.; Lio, Daisy; Brouwer, Jason M.; Uren, Rachel T.; Czabotar, Peter E.; Miller, Michelle S.; Kluck, Ruth M. 分享 收藏
Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids Miller, Michelle S.; Cowan, Angus D.; Brouwer, Jason M.; Smyth, Sean T.; Peng, Liuyu; Wardak, Ahmad Z.; Uren, Rachel T.; Luo, Cindy; Roy, Michael J.; Shah, Sayali; Tan, Ziwen; Reid, Gavin E.; Colman, Peter M.; Czabotar, Peter E. 分享 收藏
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Apoptotic cell death in disease-Current understanding of the NCCD 2023 疾病中的凋亡细胞死亡-对NCCD 2023的当前理解 Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Aqeilan, Rami, I; Arama, Eli; Baehrecke, Eric H.; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A.; Bartek, Jiri; Bazan, Nicolas G.; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Marco E.; Blagosklonny, Mikhail V.; Blander, J. Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D.; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A.; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M.; Dawson, Valina L.; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J.; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Haecker, Georg; Hajnoczky, Gyorgy; Hardwick, J. Marie; Haupt, Ygal; He, Sudan; Heery, David M.; Hengartner, Michael O.; Hetz, Claudio; Hildeman, David A.; Ichijo, Hidenori; Inoue, Satoshi; Jaeaettelae, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J.; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L.; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Kluck, Ruth; Krysko, Dmitri, V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N.; Lemasters, John J.; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; Lopez-Otin, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean-Claude; Mastroberardino, Pier G.; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A.; Moll, Ute M.; Munoz-Pinedo, Cristina; Murphy, Daniel J.; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Nunez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T.; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pentimalli, Francesca; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen H. M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rajalingam, Krishnaraj; Ravichandran, Kodi S.; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia M. P.; Rotblat, Barak; Rothlin, Carla, V; Rubinsztein, David C.; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M.; Sarosiek, Kristopher A.; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S.; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R.; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen W. G.; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M.; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G.; Vanderluit, Jacqueline L.; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K.; Vousden, Karen H.; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E.; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo 分享 收藏
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors 洞察药物再利用，以及基于哌啶的SARS-CoV-2 PLpro抑制剂的特异性和复合特性 Calleja, Dale J.; Kuchel, Nathan; Lu, Bernadine G. C.; Birkinshaw, Richard W.; Klemm, Theresa; Doerflinger, Marcel; Cooney, James P.; Mackiewicz, Liana; Au, Amanda E.; Yap, Yu Q.; Blackmore, Timothy R.; Katneni, Kasiram; Crighton, Elly; Newman, Janet; Jarman, Kate E.; Call, Melissa J.; Lechtenberg, Bernhard C.; Czabotar, Peter E.; Pellegrini, Marc; Charman, Susan A.; Lowes, Kym N.; Mitchell, Jeffrey P.; Nachbur, Ueli; Lessene, Guillaume; Komander, David 分享 收藏
Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation Robin, Adeline Y.; Miller, Michelle S.; Iyer, Sweta; Shi, Melissa X.; Wardak, Ahmad Z.; Lio, Daisy; Smith, Nicholas A.; Smith, Brian J.; Birkinshaw, Richard W.; Czabotar, Peter E.; Kluck, Ruth M.; Colman, Peter M. 分享 收藏
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL Sethi, Ashish; Horne, Christopher R.; Fitzgibbon, Cheree; Wilde, Karyn; Davies, Katherine A.; Garnish, Sarah E.; Jacobsen, Annette, V; Samson, Andre L.; Hildebrand, Joanne M.; Wardak, Ahmad; Czabotar, Peter E.; Petrie, Emma J.; Gooley, Paul R.; Murphy, James M. 分享 收藏
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Ion currents through Kir potassium channels are gated by anionic lipids Jin, Ruitao; He, Sitong; Black, Katrina A.; Clarke, Oliver B.; Wu, Di; Bolla, Jani R.; Johnson, Paul; Periasamy, Agalya; Wardak, Ahmad; Czabotar, Peter; Colman, Peter M.; Robinson, Carol, V; Laver, Derek; Smith, Brian J.; Gulbis, Jacqueline M. 分享 收藏
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis Meng, Yanxiang; Davies, Katherine A.; Fitzgibbon, Cheree; Young, Samuel N.; Garnish, Sarah E.; Horne, Christopher R.; Luo, Cindy; Garnier, Jean-Marc; Liang, Lung-Yu; Cowan, Angus D.; Samson, Andre L.; Lessene, Guillaume; Sandow, Jarrod J.; Czabotar, Peter E.; Murphy, James M. 分享 收藏
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Dynamic reconfiguration of pro-apoptotic BAK on membranes 促凋亡BAK在膜上的动态重组 Sandow, Jarrod J.; Tan, Iris Kl; Huang, Alan S.; Masaldan, Shashank; Bernardini, Jonathan P.; Wardak, Ahmad Z.; Birkinshaw, Richard W.; Ninnis, Robert L.; Liu, Ziyan; Dalseno, Destiny; Lio, Daisy; Infusini, Giuseppi; Czabotar, Peter E.; Webb, Andrew, I; Dewson, Grant 分享 收藏
BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia Carrington, Emma M.; Louis, Cynthia; Kratina, Tobias; Hancock, Manuela; Keenan, Christine R.; Iannarella, Nadia; Allan, Rhys S.; Wardak, Ahmad Z.; Czabotar, Peter E.; Herold, Marco J.; Schenk, Robyn L.; White, Christine A.; D'Silva, Damian; Yang, Yuyan; Wong, Wesley; Wong, Huon; Bryant, Vanessa L.; Huntington, Nicholas D.; Rautela, Jai; Sutherland, Robyn M.; Zhan, Yifan; Hansen, Jacinta; Duong Nhu; Lessene, Guillaume; Wicks, Ian P.; Lew, Andrew M. 分享 收藏
Structure of detergent-activated BAK dimers derived from the inert monomer Birkinshaw, Richard W.; Iyer, Sweta; Lio, Daisy; Luo, Cindy S.; Brouwer, Jason M.; Miller, Michelle S.; Robin, Adeline Y.; Uren, Rachel T.; Dewson, Grant; Kluck, Ruth M.; Colman, Peter M.; Czabotar, Peter E. 分享 收藏
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