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A

Alison D. Axtman

University of North Carolina at Chapel Hill
H指数:17
被引数:1,169

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Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5

DDX1、LGP2和MDA5第一类RNA解旋酶抑制剂的鉴定与优化

European Journal of Medicinal Chemistry
IF5.9
2026-02-260
PRE
Xiaowen Wang; Feijun Wang; Deyu Kong; Dilipkumar Uredi; Fengling Li; Feng Li; Jayachandra Rayadurgam; Hanxuan Li; Esther Wolf; U.Hang Chan; Irene Chau; Hong Zeng; Julia Garcia Perez; Derek J. Wilson; Frances M. Bashore; Xiaodong Wang; Levon Halabelian; Kevin J. Frankowski; Dmitri Kireev; Alison D. Axtman
Cascade Mono- and Di-Functionalization of Anticancer Diastereomeric Benzoxazole-Ansamycins toward the Development of Highly Potent Hsp90 Inhibitors of Decreased Toxicity in Normal Cells

抗癌差向异构苯并噁唑-安莎霉素的单-和双-官能化级联反应，用于开发低毒性高活性Hsp90抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-01-010
OA
Aleksandra Leśniewska; Adam Buczkowski; Piotr Ruszkowski; M. Binder; Alison Donnelly Axtman; Wojciech Schilf; Ewelina Smolarz; Krystian Pyta; М. Gdaniec; Franz J. Bartl; Piotr Przybylski
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-07-032
OAAI
Ong, Han Wee; Yang, Xuan; Smith, Jeffery L.; Dickmander, Rebekah J.; Brown, Jason W.; Havener, Tammy M.; Taft-Benz, Sharon; Howell, Stefanie; Sanders, Marcia K.; Capener, Jacob L.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M.
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
2023-12-013
OAAI
Du, Yuhong; Bradshaw, William J.; Leisner, Tina M.; Annor-Gyamfi, Joel K.; Qian, Kun; Bashore, Frances M.; Sikdar, Arunima; Nwogbo, Felix O.; Ivanov, Andrey A.; Frye, Stephen, V; Gileadi, Opher; Brennan, Paul E.; Levey, Allan I.; Axtman, Alison D.; Pearce, Kenneth H.; Fu, Haian; Katis, Vittorio L.
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

发现具有神经保护作用的有效且选择性的CDKL5/GSK3化学探针

ACS CHEMICAL NEUROSCIENCE
IF3.9
2023-04-214
OAAI
Ong, Han Wee; Liang, Yi; Richardson, William; Lowry, Emily R.; Wells, Carrow I.; Chen, Xiangrong; Silvestre, Margaux; Dempster, Kelvin; Silvaroli, Josie A.; Smith, Jeffery L.; Wichterle, Hynek; Pabla, Navjot S.; Ultanir, Sila K.; Bullock, Alex N.; Drewry, David H.; Axtman, Alison D.

研究方向

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D
David H. Drewry
H 指数:41论文数:276被引数:6,025
C
Carrow I. Wells
H 指数:26论文数:189被引数:2,787
T
Timothy M. Willson
H 指数:110论文数:419被引数:6.8万
J
Jeffery L. Smith
H 指数:27论文数:103被引数:3,438
F
Frances M. Bashore
H 指数:8论文数:31被引数:169
S
Stefanie Howell
H 指数:7论文数:34被引数:152
R
Rebekah J. Dickmander
H 指数:8论文数:33被引数:366
N
Nathaniel J. Moorman
H 指数:38论文数:220被引数:5,227
R
Rafael M. Couñago
H 指数:25论文数:161被引数:1,827
J
Joel K. Annor‐Gyamfi
H 指数:8论文数:24被引数:176