Holger Fischer - Publications, H-index & Citations

Holger Fischer

University Hohenheim

43H指数

128论文数

7.2K被引数

收录论文 39

发表时间

Leveraging machine learning predicted confidence for boosting assay submission and decision-making efficiencies 利用机器学习预测置信度以提升检测提交和决策制定的效率

European Journal of Medicinal Chemistry

IF5.9

2025-07-06

PREAI

Davide Bassani; Michael Reutlinger; Holger Fischer

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice

BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE

IF3.7

2025-03-01

OAAI

Chang, Wei-li; Tegang, Karly; Samuels, Benjamin A.; Saxe, Michael; Wichmann, Juergen; David, Denis J.; David, Indira Mendez; Augustin, Angelique; Fischer, Holger; Golling, Sabrina; Lamerz, Jens; Roth, Doris; Graf, Martin; Zoffmann, Sannah; Santarelli, Luca; Jagasia, Ravi; Hen, Rene

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development 未结合的脑-血浆分配系数，Kp，uu，脑-CNS药物发现和开发的游戏改变参数

PHARMACEUTICAL RESEARCH

IF4.3

2022-04-11

OAAI

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer; Shaffer, Christopher; Kalvass, Cory; Bednarczyk, Dallas; Morrison, Denise; Lesuisse, Dominique; Hoppe, Edmund; Terstappen, Georg C.; Fischer, Holger; Di, Li; Colclough, Nicola; Summerfield, Scott; Buckley, Stephen T.; Maurer, Tristan S.; Friden, Markus

Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2021-03-01

OAAI

Fischer, Holger; Senn, Claudia; Ullah, Mohammed; Cantrill, Carina; Schuler, Franz; Yu, Li

Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt

TOXICOLOGICAL SCIENCES

IF4.1

2021-01-17

OAAI

Lenz, Barbara; Brink, Andreas; Mihatsch, Michael J.; Altmann, Bernd; Niederhauser, Urs; Steinhuber, Bernd; Wyttenbach, Nicole; Fischer, Holger

Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein

NEURO-ONCOLOGY

IF13.4

2020-05-08

OAAI

Fischer, Holger; Ullah, Mohammed; de la Cruz, Cecile C.; Hunsaker, Thomas; Senn, Claudia; Wirz, Thomas; Wagner, Bjorn; Draganov, Dragomir; Vazvaei, Faye; Donzelli, Massimiliano; Paehler, Axel; Merchant, Mark; Yu, Li

In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-27

PREAI

Lombardo, Franco; Desai, Prashant V.; Arimoto, Rieko; Desino, Kelly E.; Fischer, Holger; Keefer, Christopher E.; Petersson, Carl; Winiwarter, Susanne; Broccatelli, Fabio

Soil structure breakdown following land use change from forest to maize in Northwest Vietnam 越南西北部从森林到玉米的土地利用变化后的土壤结构分解

SOIL & TILLAGE RESEARCH

IF6.8

2017-03-01

PREAI

Schweizer, Steffen A.; Fischer, Holger; Haering, Volker; Stahr, Karl

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

CHEMMEDCHEM

IF3.4

2016-09-15

PREAI

Vorberg, Raffael; Trapp, Nils; Zimmerli, Daniel; Wagner, Bjorn; Fischer, Holger; Kratochwil, Nicole A.; Kansy, Manfred; Carreira, Erick M.; Muller, Klaus

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-11-17

181

PREAI

Huchet, Quentin A.; Kuhn, Bernd; Wagner, Bjorn; Kratochwil, Nicole A.; Fischer, Holger; Kansy, Manfred; Zimmerli, Daniel; Carreira, Erick M.; Muller, Klaus

Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2015-11-01

PREAI

Assmus, Frauke; Seelig, Anna; Gobbi, Luca; Borroni, Edilio; Glaentzlin, Patricia; Fischer, Holger

Discovery of Highly Selective Brain-Penetrant Vasopressin 1a Antagonists for the Potential Treatment of Autism via a Chemogenomic and Scaffold Hopping Approach

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-02-18

PREAI

Ratni, Hasane; Rogers-Evans, Mark; Bissantz, Caterina; Grundschober, Christophe; Moreau, Jean-Luc; Schuler, Franz; Fischer, Holger; Sanchez, Ruben Alvarez; Schnider, Patrick

Carrier Mediated Distribution System (CAMDIS): A new approach for the measurement of octanol/water distribution coefficients

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2015-02-01

PREAI

Wagner, Bjoern; Fischer, Holger; Kansy, Manfred; Seelig, Anna; Assmus, Frauke

Erosion of bulk soil and soil organic carbon after land use change in northwest Vietnam

CATENA

IF5.7

2014-11-01

PREAI

Haering, V.; Fischer, H.; Stahr, K.

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors 3-氨基-3-芳基-哌啶: 一类新型的有效，选择性和口服活性的GlyT1抑制剂

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-02-06

OAAI

Pinard, Emmanuel; Alberati, Daniela; Alvarez-Sanchez, Ruben; Brom, Virginie; Burner, Serge; Fischer, Holger; Hauser, Nicole; Kolczewski, Sabine; Lengyel, Judith; Mory, Roland; Saladin, Christian; Schulz-Gasch, Tanja; Stalder, Henri

Implication of erosion on the assessment of decomposition and humification of soil organic carbon after land use change in tropical agricultural systems

SOIL BIOLOGY & BIOCHEMISTRY

IF10.3

2013-10-01

PREAI

Haering, V.; Fischer, H.; Cadisch, G.; Stahr, K.

Improved δ13C method to assess soil organic carbon dynamics on sites affected by soil erosion

EUROPEAN JOURNAL OF SOIL SCIENCE

IF3.8

2013-07-01

PREAI

Haering, V.; Fischer, H.; Cadisch, G.; Stahr, K.

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-05-02

144

PREAI

Hilpert, Hans; Guba, Wolfgang; Woltering, Thomas J.; Wostl, Wolfgang; Pinard, Emmanuel; Mauser, Harald; Mayweg, Alexander V.; Rogers-Evans, Mark; Humm, Roland; Krummenacher, Daniela; Muser, Thorsten; Schnider, Christian; Jacobsen, Helmut; Ozmen, Laurence; Bergadano, Alessandra; Banner, David W.; Hochstrasser, Remo; Kuglstatter, Andreas; David-Pierson, Pascale; Fischer, Holger; Polara, Alessandra; Narquizian, Robert

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

DRUG DISCOVERY TODAY

IF7.5

2012-08-01

131

PREAI

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F.; Faller, Bernard; Fischer, Holger; Houston, J. Brian; Kansy, Manfred; Kerns, Edward H.; Kraemer, Stefanie D.; Lennernas, Hans; Sugano, Kiyohiko

Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-05-21

PREAI

Staedler, Davide; Chapuis-Bernasconi, Catherine; Dehmlow, Henrietta; Fischer, Holger; Juillerat-Jeanneret, Lucienne; Aebi, Johannes D.

研究方向