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Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation Kailass, Karishma; Casalena, Dominick; Jenane, Lina; Mcedwards, Gregor; Auld, Douglas S.; Sadovski, Oleg; Kaye, Esther G.; Hudson, Elyse; Nettleton, David; Currie, Mark A.; Beharry, Andrew A. 分享 收藏
Screening in serum-derived medium reveals differential response to compounds targeting metabolism Abbott, Keene L.; Ali, Ahmed; Casalena, Dominick; Do, Brian T.; Ferreira, Raphael; Cheah, Jaime H.; Soule, Christian K.; Deik, Amy; Kunchok, Tenzin; Schmidt, Daniel R.; Renner, Steffen; Honeder, Sophie E.; Wu, Michelle; Chan, Sze Ham; Tseyang, Tenzin; Stoltzfus, Andrew T.; Michel, Sarah L. J.; Greaves, Daniel; Hsu, Peggy P.; Ng, Christopher W.; Zhang, Chelsea J.; Farsidjani, Ali; Kent, Johnathan R.; Madariaga, Maria Lucia L.; Gramatikov, Iva Monique T.; Matheson, Nicholas J.; Lewis, Caroline A.; Clish, Clary B.; Rees, Matthew G.; Roth, Jennifer A.; Griner, Lesley Mathews; Muir, Alexander; Auld, Douglas S.; Heiden, Matthew G. Vander 分享 收藏
The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation Markossian, Sarine; Brimacombe, Kyle R.; Sittampalam, G. Sitta; Grossman, Abigail; Coussens, Nathan P.; Inglese, James; Auld, Douglas S.; Chin, William; Austin, Christopher P.; Hall, Matthew D. 分享 收藏
Identification and validation of selective deubiquitinase inhibitors Varca, Anthony C.; Casalena, Dominick; Chan, Wai Cheung; Hu, Bin; Magin, Robert S.; Roberts, Rebekka M.; Liu, Xiaoxi; Zhu, He; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Marto, Jarrod A.; Auld, Douglas; Buhrlage, Sara J. 分享 收藏
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK Tan, Ceryl; Ginzberg, Miriam B.; Webster, Rachel; Iyengar, Seshu; Liu, Shixuan; Papadopoli, David; Concannon, John; Wang, Yuan; Auld, Douglas S.; Jenkins, Jeremy L.; Rost, Hannes; Topisirovic, Ivan; Hilfinger, Andreas; Derry, W. Brent; Patel, Nish; Kafri, Ran 分享 收藏
Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening 通过高通量化学筛选探测幼稚人类多能性的信号传导要求 Khan, Shafqat A.; Park, Kyoung-mi; Fischer, Laura A.; Dong, Chen; Lungjangwa, Tenzin; Jimenez, Marta; Casalena, Dominick; Chew, Brian; Dietmann, Sabine; Auld, Douglas S.; Jaenisch, Rudolf; Theunissen, Thorold W. 分享 收藏
Nuisance compounds in cellular assays Dahlin, Jayme L.; Auld, Douglas S.; Rothenaigner, Ina; Haney, Steve; Sexton, Jonathan Z.; Nissink, J. Willem M.; Walsh, Jarrod; Lee, Jonathan A.; Strelow, John M.; Willard, Francis S.; Ferrins, Lori; Baell, Jonathan B.; Walters, Michael A.; Hua, Bruce K.; Hadian, Kamyar; Wagner, Bridget K. 分享 收藏
Evolution of Novartis' Small Molecule Screening Deck Design 诺华小分子筛板设计的演变 Schuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K. 分享 收藏
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Systematic Chemogenetic Library Assembly Canham, Stephen M.; Wang, Yuan; Cornett, Allen; Auld, Douglas S.; Baeschlin, Daniel K.; Patoor, Maude; Skaanderup, Philip R.; Honda, Ayako; Llamas, Luis; Wendel, Greg; Mapa, Felipa A.; Aspesi, Peter, Jr.; Labbe-Giguere, Nancy; Gamber, Gabriel G.; Palacios, Daniel S.; Schuffenhauer, Ansgar; Deng, Zhan; Nigsch, Florian; Frederiksen, Mathias; Bushell, Simon M.; Rothman, Deborah; Jain, Rishi K.; Hemmerle, Horst; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Jenkins, Jeremy L. 分享 收藏
Multimodal small-molecule screening for human prion protein binders Reidenbach, Andrew G.; Mesleh, Michael F.; Casalena, Dominick; Vallabh, Sonia M.; Dahlin, Jayme L.; Leed, Alison J.; Chan, Alix I.; Usanov, Dmitry L.; Yehl, Jenna B.; Lemke, Christopher T.; Campbell, Arthur J.; Shah, Rishi N.; Shrestha, Om K.; Sacher, Joshua R.; Rangel, Victor L.; Moroco, Jamie A.; Sathappa, Murugappan; Nonato, Maria Cristina; Nguyen, Kong T.; Wright, S. Kirk; Liu, David R.; Wagner, Florence F.; Kaushik, Virendar K.; Auld, Douglas S.; Schreiber, Stuart L.; Minikel, Eric Vallabh 分享 收藏
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery Coussens, Nathan P.; Sittampalam, G. Sitta; Guha, Rajarshi; Brimacombe, Kyle; Grossman, Abigail; Chung, Thomas D. Y.; Weidner, Jeffrey R.; Riss, Terry; Trask, O. Joseph; Auld, Douglas; Dahlin, Jayme L.; Devanaryan, Viswanath; Foley, Timothy L.; Mcgee, James; Kahl, Steven D.; Kales, Stephen C.; Arkin, Michelle; Baell, Jonathan; Bejcek, Bruce; Gal-Edd, Neely; Glicksman, Marcie; Haas, Joseph V.; Iversen, Philip W.; Hoeppner, Marilu; Lathrop, Stacy; Sayers, Eric; Liu, Hanguan; Trawick, Bart; Mcvey, Julie; Lemmon, Vance P.; Li, Zhuyin; McManus, Owen; Minor, Lisa; Napper, Andrew; Wildey, Mary Jo; Pacifici, Robert; Chin, William W.; Xia, Menghang; Xu, Xin; Lal-Nag, Madhu; Hall, Matthew D.; Michael, Sam; Inglese, James; Simeonov, Anton; Austin, Christopher P. 分享 收藏
Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase Tahara, Yu-ki; Auld, Douglas; Ji, Debin; Beharry, Andrew A.; Kietrys, Anna M.; Wilson, David L.; Jimenez, Marta; King, Daniel; Nguyen, Zachary; Kool, Eric T. 分享 收藏
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models Davis, Mindy I.; Pragani, Rajan; Fox, Jennifer T.; Shen, Min; Parmar, Kalindi; Gaudiano, Emily F.; Liu, Li; Tanega, Cordelle; McGee, Lauren; Hall, Matthew D.; McKnight, Crystal; Shinn, Paul; Nelson, Henrike; Chattopadhyay, Debasish; D'Andrea, Alan D.; Auld, Douglas S.; DeLucas, Larry J.; Li, Zhuyin; Boxer, Matthew B.; Sinneonov, Anton 分享 收藏
A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics Tschapalda, Kirsten; Zhang, Ya-Qin; Liu, Li; Golovnina, Kseniya; Schlemper, Thomas; Eichmann, Thomas O.; Lal-Nag, Madhu; Sreenivasan, Urmila; McLenithan, John; Ziegler, Slava; Sztalryd, Carole; Lass, Achim; Auld, Douglas; Oliver, Brian; Waldmann, Herbert; Li, Zhuyin; Shen, Min; Boxer, Matthew B.; Beller, Mathias 分享 收藏
Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation Bill, Anke; Popa, M. Oana; van Diepen, Michiel T.; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A.; Auld, Douglas S.; Gosling, Martin; Groot-Kormelink, Paul J.; Gaither, L. Alex 分享 收藏
Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 Davis, Mindy I.; Gross, Stefan; Shen, Min; Straley, Kimberly S.; Pragani, Rajan; Lea, Wendy A.; Popovici-Muller, Janeta; DeLaBarre, Byron; Artin, Erin; Thorne, Natasha; Auld, Douglas S.; Li, Zhuyin; Dang, Lenny; Boxer, Matthew B.; Simeonov, Anton 分享 收藏
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase Brimacombe, Kyle R.; Walsh, Martin J.; Liu, Li; Vasquez-Valdivieso, Montserrat G.; Morgan, Hugh P.; McNae, Iain; Fothergill-Gilmore, Linda A.; Michels, Paul A. M.; Auld, Douglas S.; Simeonov, Anton; Walkinshaw, Malcolm D.; Shen, Min; Boxer, Matthew B. 分享 收藏
Reporter Enzyme Inhibitor Study To Aid Assembly of Orthogonal Reporter Gene Assays Ho, Pei-i; Yue, Kimberley; Pandey, Pramod; Breault, Lyne; Harbinski, Fred; McBride, Aaron J.; Webb, Brian; Narahari, Janaki; Karassina, Natasha; Wood, Keith V.; Hill, Adam; Auld, Douglas S. 分享 收藏
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