Shengdar Q. Tsai - Publications, H-index & Citations

Shengdar Q. Tsai

St Jude Children's Research Hospital

49H指数

148论文数

2.2W被引数

收录论文 65

发表时间

Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma 靶向B7-H3-CAR T细胞中的Regnase-1重编程肿瘤微环境并增强对骨肉瘤的抗肿瘤功效

Cell Reports Medicine

IF10.6

2026-09-01

PREAI

Adeshakin, Adeleye O.; Shi, Hao; Perry, S. Scott; Sheppard, Heather; Nguyen, Phuong; Sun, Xiang; Zhou, Peipei; Metais, Jean-Yves; Cunningham, Trevor; Anil, K. C.; Tian, Liqing; Peche, Vivek; Prater, Mollie S.; Langfitt, Deanna M.; O'Reilly, Carla; Park, Jeoungeun J.; Chabot, Ashley; Zhou, Sheng; Matsubara, Azusa; Lee, GaHyun; Tsai, Shengdar Q.; Pruett-Miller, Shondra M.; Talbot, Lindsay J.; Yustein, Jason T.; Krenciute, Giedre; DeRenzo, Christopher; Chi, Hongbo; Gottschalk, Stephen

Non-genotoxic transplantation and in vivo selection through epitope editing 非基因毒性移植与通过表位编辑的体内选择

Nature

IF48.5

2026-07-08

OAAI

Gabriele Casirati; Andrea Cosentino; Marta Freschi; Jing Zeng; Adele Mucci; Sébastien Levesque; Nola Neri; Enrico Drago; Viola Carzaniga; Francesco Romano; Varun Katta; Azusa Matsubara; Yichao Li; Mohammed S. Mahmoud; Moisés Chávez-Navarro; Christian Brendel; John P. Manis; Shengdar Tsai; Danilo Pellin; Daniel Bauer; Pietro Genovese

Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation 构建一种紧凑型高保真金黄色葡萄球菌Cas9变体，并阐明其扩展靶向范围及活化的机制

Nature Communications

IF15.7

2026-04-16

OAAI

Satoshi N. Omura; Ryoya Nakagawa; Shohei Kajimoto; Sae Okazaki; Soh Ishiguro; Hideto Mori; Kosuke Onishi; Yuji Kashiwakura; Takafumi Hiramoto; Kio Horinaka; Mamoru Tanaka; Hisato Hirano; Kasey Jividen; Keitaro Yamashita; Shengdar Q. Tsai; Nozomu Yachie; Tsukasa Ohmori; Hiroshi Nishimasu; Osamu Nureki

Monitoring biological effects of somatic cell genome editing 体细胞基因组编辑的生物学效应监测

Nature Reviews Genetics

IF52

2026-01-13

PREAI

Benjamin S. Freedman; Jeff W. M. Bulte; Bruce R. Conklin; Luke M. Judge; Melinda R. Dwinell; Aron M. Geurts; Madeleine J. Sitton; Vineet Mahajan; Samira Kiani; Charles A. Gersbach; Mo R. Ebrahimkhani; John J. Kelly; John A. Ronald; Ryuji Morizane; Navin Gupta; Ali Shakeri-Zadeh; Nicole Vo; Krishanu Saha; Shivani Saxena; David M. Gamm; Divya Sinha; Alice F. Tarantal; Moriel Vandsburger; Azusa Matsubara; Hongxia Fu; Shengdar Q. Tsai

Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE 利用CHANGE-seq-BE对碱基编辑器诱导的脱靶活性进行敏感且无偏的全基因组分析

Nature Biotechnology

IF41.7

2026-01-02

OAAI

Cicera R. Lazzarotto; Varun Katta; Yichao Li; Garret Manquen; Rachael K. Wood; Jacqueline Chyr; Elizabeth Urbina; Azusa Matsubara; GaHyun Lee; Xiaolin Wu; Suk See De Ravin; Shengdar Q. Tsai

Measurement and clinical interpretation of CRISPR off-targets CRISPR脱靶效应的测量与临床解读

Nature Genetics

IF29

2025-11-24

PREAI

Ariella Angelini Stewart; Rebecca C. Ahrens-Nicklas; Shengdar Q. Tsai; Kiran Musunuru; Petros Giannikopoulos; Claire D. Clelland

PARADIGM: ST. JUDE INITIATIVE TO ADVANCE DEVELOPMENT OF INDIVIDUALIZED BASE AND PRIME EDITING THERAPIES FOR BONE MARROW FAILURE SYNDROMES

EJC Paediatric Oncology

IF0

2025-11-01

OAAI

Kennedy, Andrea; Das Gupta, Neha; Kennedy, Alyssa; Weiss, Mitch; Tsai, Shengdar; Bhoopalan, Senthil; Wlodarski, Marcin

Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice 使用定制的CRISPR–Cas9碱基编辑器治疗小鼠中的严重血管疾病

Nature Biomedical Engineering

IF26.6

2025-09-11

PREAI

Christiano R. R. Alves; Sabyasachi Das; Vijai Krishnan; Leillani L. Ha; Lauren R. Fox; Hannah E. Stutzman; Claire E. Shamber; Pazhanichamy Kalailingam; Siobhan McCarthy; Christian L. Lino Cardenas; Claire E. Fong; Takahiko Imai; Sunayana Mitra; Shuqi Yun; Rachael K. Wood; Friederike M. C. Benning; Kangsan Roh; Joseph Lawton; Nahye Kim; Rachel A. Silverstein; Joana Ferreira da Silva; Demitri de la Cruz; Rashmi Richa; Jun Xie; Heather L. Gray-Edwards; Rajeev Malhotra; David Y. Chung; Luke H. Chao; Shengdar Q. Tsai; Casey A. Maguire; Mark E. Lindsay; Benjamin P. Kleinstiver; Patricia L. Musolino

GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats GenomePAM使用哺乳动物基因组重复序列指导PAM表征和crispr-cas核酸酶的工程化

Nature Biomedical Engineering

IF26.6

2025-08-13

OAAI

Miao Yu; Limei Ai; Bang Wang; Shifeng Lian; Lawrence Ip; James Liu; Linxian Li; Shengdar Q. Tsai; Benjamin P. Kleinstiver; Zongli Zheng

Virus-free CRISPR knockin of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells 将嵌合抗原受体无病毒CRISPR敲入KLRC1可生成强效GD2特异性自然杀伤细胞

MOLECULAR THERAPY

IF12

2025-01-01

PREAI

Shankar, Keerthana; Zingler-Hoslet, Isabelle; Tabima, Diana M.; Zima, Seth; Shi, Lei; Gimse, Kirstan; Forsberg, Matthew H.; Katta, Varun; Davis, Sage Z.; Maldonado, Daniel; Russell, Brittany E.; Murtaza, Muhammed; Tsai, Shengdar Q.; Ayuso, Jose M.; Capitini, Christian M.

High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease 造血干细胞的高保真无PAMless碱基编辑治疗慢性肉芽肿病

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-10-16

PREAI

Bzhilyanskaya, Vera; Ma, Linyuan; Liu, Siyuan; Fox, Lauren R.; Whittaker, Madelynn N.; Meis, Ronald J.; Choi, Uimook; Lawson, Amanda; Ma, Michelle; Theobald, Narda; Burkett, Sandra; Sweeney, Colin L.; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Lack, Justin B.; Wu, Xiaolin; Dahl, Gary A.; Malech, Harry L.; Kleinstiver, Benjamin P.; De Ravin, Suk See

Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+cell therapy to induce fetal hemoglobin for sickle cell disease 新型Cas9基因组编辑的自体CD34细胞疗法诱导胎儿血红蛋白治疗镰状细胞病的开发和IND支持研究

MOLECULAR THERAPY

IF12

2024-10-01

OAAI

Katta, Varun; O'Keefe, Kiera; Li, Yichao; Mayuranathan, Thiyagaraj; Lazzarotto, Cicera R.; Wood, Rachael K.; Levine, Rachel M.; Powers, Alicia; Mayberry, Kalin; Manquen, Garret; Yao, Yu; Zhang, Jingjing; Jang, Yoonjeong; Nimmagadda, Nikitha; Dempsey, Erin A.; Lee, GaHyun; Uchida, Naoya; Cheng, Yong; Fazio, Frank; Lockey, Tim; Meagher, Mike; Sharma, Akshay; Tisdale, John F.; Zhou, Sheng; Yen, Jonathan S.; Weiss, Mitchell J.; Tsai, Shengdar Q.

Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy 用于SMN2功能矫正的碱基编辑器的优化，以治疗脊髓性肌萎缩症

NATURE BIOMEDICAL ENGINEERING

IF26.6

2023-12-06

OAAI

Alves, Christiano R. R.; Ha, Leillani L.; Yaworski, Rebecca; Sutton, Emma R.; Lazzarotto, Cicera R.; Christie, Kathleen A.; Reilly, Aoife; Beauvais, Ariane; Doll, Roman M.; de la Cruz, Demitri; Maguire, Casey A.; Swoboda, Kathryn J.; Tsai, Shengdar Q.; Kothary, Rashmi; Kleinstiver, Benjamin P.

Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-12-01

OAAI

Cavazza, Alessia; Hendel, Ayal; Bak, Rasmus O.; Rio, Paula; Guell, Marc; Lainscek, Dusko; Arechavala-Gomeza, Virginia; Peng, Ling; Hapil, Fatma Zehra; Harvey, Joshua; Ortega, Francisco G.; Gonzalez-Martinez, Coral; Lederer, Carsten W.; Mikkelsen, Kasper; Gasiunas, Giedrius; Kalter, Nechama; Goncalves, Manuel A. F. V.; Petersen, Julie; Garanto, Alejandro; Montoliu, Lluis; Maresca, Marcello; Seemann, Stefan E.; Gorodkin, Jan; Mazini, Loubna; Sanchez, Rosario; Rodriguez-Madoz, Juan R.; Maldonado-Perez, Noelia; Laura, Torella; Schmueck-Henneresse, Michael; Maccalli, Cristina; Gruenewald, Julian; Carmona, Gloria; Kachamakova-Trojanowska, Neli; Miccio, Annarita; Martin, Francisco; Turchiano, Giandomenico; Cathomen, Toni; Luo, Yonglun; Tsai, Shengdar Q.; Benabdellah, Karim

Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells

CRISPR JOURNAL

IF4

2023-10-01

OAAI

Molugu, Kaivalya; Khajanchi, Namita; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Saha, Krishanu

Potent and uniform fetal hemoglobin induction via base editing

NATURE GENETICS

IF31.8

2023-07-03

OAAI

Mayuranathan, Thiyagaraj; Newby, Gregory A.; Feng, Ruopeng; Yao, Yu; Mayberry, Kalin D.; Lazzarotto, Cicera R.; Li, Yichao; Levine, Rachel M.; Nimmagadda, Nikitha; Dempsey, Erin; Kang, Guolian; Porter, Shaina N.; Doerfler, Phillip A.; Zhang, Jingjing; Jang, Yoonjeong; Chen, Jingjing; Bell, Henry W.; Crossley, Merlin; Bhoopalan, Senthil Velan; Sharma, Akshay; Tisdale, John F.; Pruett-Miller, Shondra M.; Cheng, Yong; Tsai, Shengdar Q.; Liu, David R.; Weiss, Mitchell J.; Yen, Jonathan S.

CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-01-04

OAAI

Brault, Julie; Liu, Taylor; Liu, Siyuan; Lawson, Amanda; Choi, Uimook; Kozhushko, Nikita; Bzhilyanskaya, Vera; Pavel-Dinu, Mara; Meis, Ronald J.; Eckhaus, Michael A.; Burkett, Sandra S.; Bosticardo, Marita; Kleinstiver, Benjamin P.; Notarangelo, Luigi D.; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Wu, Xiaolin; Dahl, Gary A.; Porteus, Matthew H.; Malech, Harry L.; De Ravin, Suk See

Human genetic diversity alters off-target outcomes of therapeutic gene editing 人类遗传多样性改变治疗性基因编辑的脱靶结果

NATURE GENETICS

IF31.8

2022-12-15

OAAI

Cancellieri, Samuele; Zeng, Jing; Lin, Linda Yingqi; Tognon, Manuel; Nguyen, My Anh; Lin, Jiecong; Bombieri, Nicola; Maitland, Stacy A.; Ciuculescu, Marioara-Felicia; Katta, Varun; Tsai, Shengdar Q.; Armant, Myriam; Wolfe, Scot A.; Giugno, Rosalba; Bauer, Daniel E.; Pinello, Luca

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression 能够诱导实体瘤消退的无病毒crispr-car T细胞的产生和表征

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2022-09-07

OAAI

Mueller, Katherine P.; Piscopo, Nicole J.; Forsberg, Matthew H.; Saraspe, Louise A.; Das, Amritava; Russell, Brittany; Smerchansky, Madeline; Cappabianca, Dan; Shi, Lei; Shankar, Keerthana; Sarko, Lauren; Khajanchi, Namita; Denne, Nina La Vonne; Ramamurthy, Apoorva; Ali, Adeela; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Capitini, Christian M.; Saha, Krishanu

In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

NATURE BIOTECHNOLOGY

IF41.7

2022-06-09

OAAI

Nahmad, Alessio D.; Lazzarotto, Cicera R.; Zelikson, Natalie; Kustin, Talia; Tenuta, Mary; Huang, Deli; Reuveni, Inbal; Nataf, Daniel; Raviv, Yuval; Horovitz-Fried, Miriam; Dotan, Iris; Carmi, Yaron; Rosin-Arbesfeld, Rina; Nemazee, David; Voss, James E.; Stern, Adi; Tsai, Shengdar Q.; Barzel, Adi

研究方向