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Benjamin P. Kleinstiver

massachusetts general hospital
H指数:41
被引数:1.4万

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Toward the clinical application of long-read sequencing in repeat-expansion disorders

长读测序在重复序列扩增疾病中的临床应用展望

Nature Genetics
IF29
2026-08-200
PRE
Louise Benarroch; Jovan Pešović; Marzia Rossato; Zhongbo Chen; Morghan C. Lucas; Guillaume Cogan; Indhu-Shree Rajan-Babu; Vitus Prokosch; Christina Zarouchlioti; Marco Carlomagno; Ida Höijer; Mayra Sauer; Ismail Jamail; Shota Shibata; Glen Lester Sequiera; Benjamin P. Kleinstiver; Sonia Lameiras; Ricardo Mouro Pinto; Giuseppe Novelli; Davina Hensman Moss; Natalia Dominik; Mathieu Barbier; Isabelle Le Ber; Guillaume Bassez; Denis Furling; Massimo Delledonne; Karen Usdin; Sylvain Baulande; Geneviève Gourdon; Birgitt Schüle; Dušanka Savić-Pavićević; Annalisa Botta; Alice E. Davidson; Adam Ameur; Vincent Dion; Stéphanie Tomé
Mechanistic machine learning for prediction of prime editing outcomes

机器学习方法预测碱基编辑结果机制

Nature Biotechnology
IF41.7
2026-08-120
OAAI
Alvin Hsu; Peter J. Chen; Angus H. Li; Colin F. Hemez; Xin D. Gao; Markus Terrey; Charlie Nelson; Vijay Selvam; Ana Cristian; Amber N. McElroy; Benjamin J. Steinbeck; Gandhar K. Mahadeshwar; Smriti Pandey; Zachary Barsdale; Paul Z. Chen; Alexander A. Sousa; Holt A. Sakai; Rachel A. Silverstein; Ilias Morad; Ryan K. Krueger; Max W. Shen; Benjamin P. Kleinstiver; Cathleen M. Lutz; Jakub Tolar; Bruce R. Blazar; Mark J. Osborn; David R. Liu
Extracellular vesicles-mediated delivery of SpCas9 RNPs for therapeutic gene editing in Spinocerebellar Ataxia Type 3

外泌体介导的SpCas9核糖核蛋白递送，用于脊髓小脑共济失调3型的治疗性基因编辑

Biomaterials
IF12.9
2026-03-090
OAAI
Kevin Leandro; David Rufino-Ramos; Sara M. Lopes; Francisca Santos Silva; Paulo Rodrigues-Santos; Ana Carolina Silva; Ana Rita Fernandes; Carina Henriques; Dina Pereira; Diana Lobo; Guilherme L. Gabriel; Rosário Faro; Rui Jorge Nobre; Pedro R.L. Perdigão; Benjamin P. Kleinstiver; Luís Pereira de Almeida
Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing

通过平铺碱基编辑的等位基因读出调控元件的核苷酸分辨率定位

Nature Communications
IF15.7
2026-03-030
OAAI
Basheer Becerra; Sandra Wittibschlager; Zain M. Patel; Ana P. Kutschat; Justin Delano; Eric Che; Anzhelika Tauber; Ting Wu; Marlena Starrs; Christina S. Horstmann; Sophie Müller; Madelynn N. Whittaker; Elise Sylvander; Manfred Lehner; Michael I. Love; Benjamin P. Kleinstiver; Martin Jankowiak; Daniel E. Bauer; Davide Seruggia; Luca Pinello
Customizing CRISPR–Cas PAM specificity with protein language models

使用蛋白质语言模型定制crispr-cas PAM特异性

Nature Biotechnology
IF41.7
2026-02-020
PRE
Stephen Nayfach; Aadyot Bhatnagar; Andrey Novichkov; Nahye Kim; Alexander M. Hoffnagle; Riffat Hussain; Gabriella O. Estevam; Emily Hill; Jeffrey A. Ruffolo; Rachel A. Silverstein; Joseph Gallagher; Benjamin P. Kleinstiver; Alexander J. Meeske; Peter Cameron; Ali Madani
An opportune time for targeted brain arteriovenous malformation therapy

靶向脑动静脉畸形治疗的有利时机

JOURNAL OF NEUROSURGERY
IF3.6
2025-12-010
PRE
Hale, Andrew T.; Kalailingam, Pazhanichamy; Kundishora, Adam J.; Reeves, Benjamin C.; Brastianos, Priscilla K.; Shih, Helen A.; Jain, Rakesh K.; Ning, Mingming; Stapleton, Christopher J.; Patel, Aman B.; Smith, Edward R.; Chapman, Paul H.; Rabinov, James D.; Kleinstiver, Benjamin P.; Musolino, Patricia L.; Kahle, Kristopher T.
Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice

使用定制的CRISPR–Cas9碱基编辑器治疗小鼠中的严重血管疾病

Nature Biomedical Engineering
IF26.6
2025-09-110
PRE
Christiano R. R. Alves; Sabyasachi Das; Vijai Krishnan; Leillani L. Ha; Lauren R. Fox; Hannah E. Stutzman; Claire E. Shamber; Pazhanichamy Kalailingam; Siobhan McCarthy; Christian L. Lino Cardenas; Claire E. Fong; Takahiko Imai; Sunayana Mitra; Shuqi Yun; Rachael K. Wood; Friederike M. C. Benning; Kangsan Roh; Joseph Lawton; Nahye Kim; Rachel A. Silverstein; Joana Ferreira da Silva; Demitri de la Cruz; Rashmi Richa; Jun Xie; Heather L. Gray-Edwards; Rajeev Malhotra; David Y. Chung; Luke H. Chao; Shengdar Q. Tsai; Casey A. Maguire; Mark E. Lindsay; Benjamin P. Kleinstiver; Patricia L. Musolino
Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model

非侵入性检测异种移植小鼠模型中TOR1A DYT1等位基因特异的CRISPR-SaCas9-KKH破坏

MOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
2025-01-010
OAAI
Maalouf, Katia E.; Frederick, Dawn Madison; Sharma, Nutan; Abou Haidar, Edwina; Xiao, Tianhe; Han, Justin Seungkyu; Mahamdeh, Mohammed S.; Soberman, Roy J.; Rufino-Ramos, David; Kleinstiver, Benjamin P.; Jinnah, Hyder A.; Vaine, Christine A.; Bragg, D. Cristopher
CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice

通过单一腺相关病毒载体对mmu-miR-21a进行CRISPR靶向治疗可延长胶质母细胞瘤小鼠的生存期

MOLECULAR THERAPY
IF12
2025-01-011
OAAI
Nieland, Lisa; Vrijmoet, Anne B.; Jetten, Isabelle W.; Rufino-Ramos, David; de Reus, Alexandra J. E. M.; Breyne, Koen; Kleinstiver, Benjamin P.; Maguire, Casey A.; Broekman, Marike L. D.; Breake, Xandra O.; Abels, Erik R.
Myocardial infarction augments sleep to limit cardiac inflammation and damage
Nature
IF48.5
2024-10-300
PRE
Pacific Huynh; Jan D. Hoffmann; Teresa Gerhardt; Máté G. Kiss; Faris M. Zuraikat; Oren Cohen; Christopher Wolfram; Abi G. Yates; Alexander Leunig; Merlin Heiser; Lena Gaebel; Matteo Gianeselli; Sukanya Goswami; Annie Khamhoung; Jeffrey Downey; Seonghun Yoon; Zhihong Chen; Vladimir Roudko; Travis Dawson; Joana Ferreira da Silva; Natalie J. Ameral; Jarod Morgenroth-Rebin; Darwin D’Souza; Laura L. Koekkoek; Walter Jacob; Jazz Munitz; Donghoon Lee; John F. Fullard; Mandy M. T. van Leent; Panos Roussos; Seunghee Kim-Schulze; Neomi Shah; Benjamin P. Kleinstiver; Filip K. Swirski; David Leistner; Marie-Pierre St-Onge; Cameron S. McAlpine
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease

造血干细胞的高保真无PAMless碱基编辑治疗慢性肉芽肿病

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-10-160
PRE
Bzhilyanskaya, Vera; Ma, Linyuan; Liu, Siyuan; Fox, Lauren R.; Whittaker, Madelynn N.; Meis, Ronald J.; Choi, Uimook; Lawson, Amanda; Ma, Michelle; Theobald, Narda; Burkett, Sandra; Sweeney, Colin L.; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Lack, Justin B.; Wu, Xiaolin; Dahl, Gary A.; Malech, Harry L.; Kleinstiver, Benjamin P.; De Ravin, Suk See
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat
NATURE COMMUNICATIONS
IF15.7
2024-04-122
OAAI
Mclean, Zachariah L.; Gao, Dadi; Correia, Kevin; Roy, Jennie C. L.; Shibata, Shota; Farnum, Iris N.; Valdepenas-Mellor, Zoe; Kovalenko, Marina; Rapuru, Manasa; Morini, Elisabetta; Ruliera, Jayla; Gillis, Tammy; Lucente, Diane; Kleinstiver, Benjamin P.; Lee, Jong-Min; Macdonald, Marcy E.; Wheeler, Vanessa C.; Mouro Pinto, Ricardo; Gusella, James F.
In situ architecture of Opa1-dependent mitochondrial cristae remodeling
EMBO JOURNAL
IF8.3
2024-01-159
OAAI
Fry, Michelle Y.; Navarro, Paula P.; Hakim, Pusparanee; Ananda, Virly Y.; Qin, Xingping; Landoni, Juan C.; Rath, Sneha; Inde, Zintis; Lugo, Camila Makhlouta; Luce, Bridget E.; Ge, Yifan; Mcdonald, Julie L.; Ali, Ilzat; Ha, Leillani L.; Kleinstiver, Benjamin P.; Chan, David C.; Sarosiek, Kristopher A.; Chao, Luke H.
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy

用于SMN2功能矫正的碱基编辑器的优化，以治疗脊髓性肌萎缩症

NATURE BIOMEDICAL ENGINEERING
IF26.6
2023-12-065
OA
Alves, Christiano R. R.; Ha, Leillani L.; Yaworski, Rebecca; Sutton, Emma R.; Lazzarotto, Cicera R.; Christie, Kathleen A.; Reilly, Aoife; Beauvais, Ariane; Doll, Roman M.; de la Cruz, Demitri; Maguire, Casey A.; Swoboda, Kathryn J.; Tsai, Shengdar Q.; Kothary, Rashmi; Kleinstiver, Benjamin P.
PAM-flexible genome editing with an engineered chimeric Cas9
NATURE COMMUNICATIONS
IF15.7
2023-10-0411
OAAI
Zhao, Lin; Koseki, Sabrina R. T.; Silverstein, Rachel A.; Amrani, Nadia; Peng, Christina; Kramme, Christian; Savic, Natasha; Pacesa, Martin; Rodriguez, Tomas C.; Stan, Teodora; Tysinger, Emma; Hong, Lauren; Yudistyra, Vivian; Ponnapati, Manvitha R.; Jacobson, Joseph M.; Church, George M.; Jakimo, Noah; Truant, Ray; Jinek, Martin; Kleinstiver, Benjamin P.; Sontheimer, Erik J.; Chatterjee, Pranam

研究方向

暂未获取到该数据
J
J. Keith Joung
H 指数:91论文数:222被引数:5.6万
S
Shengdar Q. Tsai
H 指数:49论文数:150被引数:2.2万
R
Russell T. Walton
H 指数:11论文数:16被引数:2,521
M
Michelle S. Prew
H 指数:12论文数:17被引数:5,970
C
Casey A. Maguire
H 指数:40论文数:105被引数:8,371
X
Xandra O. Breakefield
H 指数:99论文数:387被引数:6.2万
M
Martin J. Aryee
H 指数:65论文数:207被引数:4.4万
K
Kathleen A. Christie
H 指数:16论文数:28被引数:2,376
B
Bence György
H 指数:32论文数:78被引数:8,480
J
Jonathan Y. Hsu
H 指数:28论文数:48被引数:1.4万