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J

Joanne Wilson

AstraZeneca
H指数:25
被引数:3,200

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Achieving human brain exposure with the oral ataxia-telangiectasia mutated kinase inhibitor AZD1390, a substrate of aldehyde oxidase

通过口服A-T突变酶抑制剂AZD1390（醛氧化酶底物）实现人脑暴露。

Drug Metabolism and Disposition
IF4
2025-06-030
PRE
Nicola Colclough; Alexandra L. Orton; Scott Martin; Martin Wild; Venkatesh Pilla Reddy; Eva Lenz; Roshini Markandu; Joanne Wilson; Chunling Fan; Julian Potter; David Dai; Christina Chan; Jennie Roberts; Aixiang Xue; Petar Pop-Damkov; Andy Sykes; Barry Jones; Thomas A. Hunt; Kurt G. Pike; Dermot F. McGinnity
Metabolism-driven in vitro/in vivo disconnect of an oral ERα VHL-PROTAC
COMMUNICATIONS BIOLOGY
IF5.1
2024-05-135
OAAI
Hayhow, Thomas G.; Williamson, Beth; Lawson, Mandy; Cureton, Natalie; Braybrooke, Erin L.; Campbell, Andrew; Carbajo, Rodrigo J.; Cheraghchi-Bashi, Azadeh; Chiarparin, Elisabetta; Diene, Coura R.; Fallan, Charlene; Fisher, David I.; Goldberg, Frederick W.; Hopcroft, Lorna; Hopcroft, Philip; Jackson, Anne; Kettle, Jason G.; Klinowska, Teresa; Kuenzel, Ulrike; Lamont, Gillian; Lewis, Hilary J.; Maglennon, Gareth; Martin, Scott; Gutierrez, Pablo Morentin; Morrow, Christopher J.; Nikolaou, Myria; Nissink, J. Willem M.; O'Shea, Patrick; Polanski, Radoslaw; Schade, Markus; Scott, James S.; Smith, Aaron; Weber, Judith; Wilson, Joanne; Yang, Bin; Crafter, Claire
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging
ANALYTICAL CHEMISTRY
IF6.7
2022-01-1024
PRE
Strittmatter, Nicole; Richards, Frances M.; Race, Alan M.; Ling, Stephanie; Sutton, Daniel; Nilsson, Anna; Wallez, Yann; Barnes, Jennifer; Maglennon, Gareth; Gopinathan, Aarthi; Brais, Rebecca; Wong, Edmond; Serra, Maria Paola; Atkinson, James; Smith, Aaron; Wilson, Joanne; Hamm, Gregory; Johnson, Timothy, I; Dunlop, Charles R.; Kaistha, Brajesh P.; Bunch, Josephine; Sansom, Owen J.; Takats, Zoltan; Andren, Per E.; Lau, Alan; Barry, Simon T.; Goodwin, Richard J. A.; Jodrell, Duncan, I
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-02-0516
OAAI
Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
NATURE COMMUNICATIONS
IF15.7
2019-11-07237
OAAI
Fok, Jacqueline H. L.; Ramos-Montoya, Antonio; Vazquez-Chantada, Mercedes; Wijnhoven, Paul W. G.; Follia, Valeria; James, Neil; Farrington, Paul M.; Karmokar, Ankur; Willis, Sophie E.; Cairns, Jonathan; Nikkila, Jenni; Beattie, David; Lamont, Gillian M.; Finlay, M. Raymond, V; Wilson, Joanne; Smith, Aaron; O'Connor, Lenka Oplustil; Ling, Stephanie; Fawell, Stephen E.; O'Connor, Mark J.; Hollingsworth, Simon J.; Dean, Emma; Goldberg, Frederick W.; Davies, Barry R.; Cadogan, Elaine B.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-07-3154
OAAI
Karlin, Jeremy; Allen, Jasmine; Ahmad, Syed F.; Hughes, Gareth; Sheridan, Victoria; Odedra, Rajesh; Farrington, Paul; Cadogan, Elaine B.; Riches, Lucy C.; Garcia-Trinidad, Antonio; Thomason, Andrew G.; Patel, Bhavika; Vincent, Jennifer; Lau, Alan; Pike, Kurt G.; Hunt, Thomas A.; Sule, Amrita; Valerie, Nicholas C. K.; Biddlestone-Thorpe, Laura; Kahn, Jenna; Beckta, Jason M.; Mukhopadhyay, Nitai; Barlaam, Bernard; Degorce, Sebastien L.; Kettle, Jason; Colclough, Nicola; Wilson, Joanne; Smith, Aaron; Barrett, Ian P.; Zheng, Li; Zhang, Tianwei; Wang, Yingchun; Chen, Kan; Pass, Martin; Durant, Stephen T.; Valerie, Kristoffer
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
SCIENCE ADVANCES
IF12.5
2018-06-01221
OAAI
Durant, Stephen T.; Zheng, Li; Wang, Yingchun; Chen, Kan; Zhang, Lingli; Zhang, Tianwei; Yang, Zhenfan; Riches, Lucy; Trinidad, Antonio G.; Fok, Jacqueline H. L.; Hunt, Tom; Pike, Kurt G.; Wilson, Joanne; Smith, Aaron; Colclough, Nicola; Reddy, Venkatesh Pilla; Sykes, Andrew; Janefeldt, Annika; Johnstrom, Peter; Varnas, Katarina; Takano, Akihiro; Ling, Stephanie; Orme, Jonathan; Stott, Jonathan; Roberts, Caroline; Barrett, Ian; Jones, Gemma; Roudier, Martine; Pierce, Andrew; Allen, Jasmine; Kahn, Jenna; Sule, Amrita; Karlin, Jeremy; Cronin, Anna; Chapman, Melissa; Valerie, Kristoffer; Illingworth, Ruth; Pass, Martin
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-04-23101
OAAI
Pike, Kurt G.; Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Chen, Yingxue; Colclough, Nicola; Davies, Nichola L.; de-Almeida, Camila; Degorce, Sebastien L.; Didelot, Myriam; Dishington, Allan; Ducray, Richard; Durant, Stephen T.; Hassall, Lorraine A.; Holmes, Jane; Hughes, Gareth D.; MacFaul, Philip A.; Mulholland, Keith R.; McGuire, Thomas M.; Ouvry, Gilles; Pass, Martin; Robb, Graeme; Stratton, Natalie; Wang, Zhenhua; Wilson, Joanne; Zhai, Baochang; Zhao, Kang; Al-Huniti, Nidal
Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
CANCER DISCOVERY
IF33.3
2017-03-05308
OAAI
Toy, Weiyi; Weir, Hazel; Razavi, Pedram; Lawson, Mandy; Goeppert, Anne U.; Mazzola, Anne Marie; Smith, Aaron; Wilson, Joanne; Morrow, Christopher; Wong, Wai Lin; De Stanchina, Elisa; Carlson, Kathryn E.; Martin, Teresa S.; Uddin, Sharmeen; Li, Zhiqiang; Fanning, Sean; Katzenellenbogen, John A.; Greene, Geoffrey; Baselga, Jose; Chandarlapaty, Sarat
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2016-02-10168
OAAI
Ashton, Susan; Song, Young Ho; Nolan, Jim; Cadogan, Elaine; Murray, Jim; Odedra, Rajesh; Foster, John; Hall, Peter A.; Low, Susan; Taylor, Paula; Ellston, Rebecca; Polanska, Urszula M.; Wilson, Joanne; Howes, Colin; Smith, Aaron; Goodwin, Richard J. A.; Swales, John G.; Strittmatter, Nicole; Takats, Zoltan; Nilsson, Anna; Andren, Per; Trueman, Dawn; Walker, Mike; Reimer, Corinne L.; Troiano, Greg; Parsons, Donald; De Witt, David; Ashford, Marianne; Hrkach, Jeff; Zale, Stephen; Jewsbury, Philip J.; Barry, Simon T.

研究方向

暂未获取到该数据
A
Aaron Smith
H 指数:41论文数:164被引数:6,733
E
Elaine Cadogan
H 指数:26论文数:128被引数:2,860
K
Kurt G. Pike
H 指数:24论文数:94被引数:2,060
S
Simon T. Barry
H 指数:57论文数:552被引数:1.3万
S
Stephen T. Durant
H 指数:25论文数:109被引数:3,313
R
Rajesh Odedra
H 指数:29论文数:187被引数:3,315
A
Alan Lau
H 指数:37论文数:108被引数:9,973
S
Stephanie Ling
H 指数:13论文数:38被引数:1,909
D
Dawn Trueman
H 指数:6论文数:53被引数:465
P
Paul D. Smith
H 指数:58论文数:274被引数:1.3万