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E

Ernest Hamel

national institutes of health

87H-index
658Paper Count
2.9WCitation Count
Published Papers 273
Publication Date
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Correction to “Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer”
errJournal of Medicinal Chemistry
IF6.8
err2026-03-25
err0
errOAAI
errDomiziana Masci; Lele Ling; Lian Yang; Michela Puxeddu; Claudia Colla; Marianna Nalli; Antonio Coluccia; Martina Santelli; Pietro Sciò; Petra Cuřínová; Mohammad Salik Zeya Ansari; Chiara Naro; Claudio Sette; Lucia Jimenez; Wolfgang Link; Chiara Bigogno; Giulio Dondio; Ernest Hamel; Te Liu; Romano Silvestri; Giuseppe La Regina
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Discovery of multitargeting single agents as a novel route to the potential treatment of neurodegenerative diseases
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2026-01-07
err0
errOAAI
errJeetal Vyas; Anuj S. Jamenis; Krishna Kaku; Yesha Shah; Kristin M. Miner; Tarun N. Bhatia; Roxanne E. Kim; Ruoli Bai; Ernest Hamel; Rehana K. Leak; Aleem Gangjee
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Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene; Benzosuberene; and Indole-based Inhibitors of Tubulin Polymerization
errRSC Med. Chem.
IF3.6
err2025-08-29
err0
errOAAI
errZhe Shi; Rajsekhar Guddneppanavar; Blake A Winn; Matthew T Macdonough; Clinton George; Yifan Wang; Mark Zimmer; Jeni Gerberich; Alex Winters; Elisa Lin; Casey J Maguire; Jacob Ford; Ernest Hamel; Ralph Mason; Mary Lynn Trawick; Kevin G. Pinney
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errSave
Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach
errRSC Med. Chem.
IF3.6
err2025-08-22
err0
errOAAI
errDomiziana Masci; Michela Puxeddu; Claudia Colla; Antonio Coluccia; Martina Santelli; Pietro Sciò; Elena Mariotto; Giampietro Viola; Ernest Hamel; Rosa Lerose; Carmela Mazzoccoli; Romano Silvestri; Giuseppe La Regina
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Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2025-02-01
err1
PREAI
errVairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel, Ernest; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
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Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2024-12-01
err0
errOAAI
errKong, Yali; Edler, Michael C.; Hamel, Ernest; Britton-Jenkins, Asa R.; Gillan, Omar; Mooberry, Susan L.; Mu, David; Brown, Milton L.
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errSave
Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-05-21
err3
errOAAI
errMilunovic, Miljan N. M.; Ohui, Katerina; Besleaga, Iuliana; Petrasheuskaya, Tatsiana V.; Domotor, Orsolya; Enyedy, Eva A.; Darvasiova, Denisa; Rapta, Peter; Barbierikova, Zuzana; Vegh, Daniel; Toth, Szilard; Toth, Judit; Kucsma, Nora; Szakacs, Gergely; Popovic-Bijelic, Ana; Zafar, Ayesha; Reynisson, Johannes; Shutalev, Anatoly D.; Bai, Ruoli; Hamel, Ernest; Arion, Vladimir B.
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Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?
errDALTON TRANSACTIONS
IF3.3
err2024-01-01
err0
errOAAI
errBesleaga, Iuliana; Raptova, Renata; Stoica, Alexandru-Constantin; Milunovic, Miljan N. M.; Zalibera, Michal; Bai, Ruoli; Igaz, Nora; Reynisson, Johannes; Kiricsi, Monika; Enyedy, Eva A.; Rapta, Peter; Hamel, Ernest; Arion, Vladimir B.
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Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroy-l-indole analogues as inhibitors of tubulin polymerization
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-01-01
err8
PREAI
errRen, Wen; Deng, Yuling; Ward, Jacob D.; Vairin, Rebecca; Bai, Ruoli; Wanniarachchi, Hashini I.; Hamal, Khagendra B.; Tankoano, Pouguiniseli E.; Tamminga, Caleb S.; Bueno, Lorena M. A.; Hamel, Ernest; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
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4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-30
err3
errOAAI
errMasci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D'Ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Scio, Pietro; Orlando, Viviana; D'Angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T.; Silvestri, Romano; La Regina, Giuseppe
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Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2023-09-01
err3
errOAAI
errRen, Wen; Vairin, Rebecca; Ward, Jacob D.; Francis, Ricardo; VanNatta, Jenny; Bai, Ruoli; Tankoano, Pouguiniseli E.; Deng, Yuling; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
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errSave
Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
errJOURNAL OF MOLECULAR STRUCTURE
IF4.7
err2023-08-01
err18
errOAAI
errHawash, Mohammed; Ergun, Sezen Guntekin; Kahraman, Deniz Cansen; Olgac, Abdurrahman; Hamel, Ernest; Cetin-Atalay, Rengul; Baytas, Sultan Nacak
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Identification of pyrrolo[3′,4′:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-06-01
err21
errOAAI
errBarreca, Marilia; Spano, Virginia; Rocca, Roberta; Bivacqua, Roberta; Gualtieri, Gianmarco; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Manfreda, Lorenzo; Bai, Ruoli; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Viola, Giampietro; Barraja, Paola
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6244: Design, synthesis, and structure-activity relationships of substituted pyrido[ 3,2d] pyrimidines as microtubule targeting agents and anti- cancer agents
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errShah, Yesha Vijaykumar; Bai, Ruoli; Hamel, Ernest; Gangjee, Aleem
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Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2023-03-01
err6
errOAAI
errChoudhary, Shruti; Kaku, Krishna; Robles, Andrew J.; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem
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errSave
Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(ii) complexes as microtubule destabilizing agents
errDALTON TRANSACTIONS
IF3.3
err2023-01-01
err5
errOAAI
errWittmann, Christopher; Domotor, Orsolya; Kuznetcova, Irina; Spengler, Gabriella; Reynisson, Johannes; Holder, Lauren; Miller, Gavin J. J.; Enyedy, Eva A. A.; Bai, Ruoli; Hamel, Ernest; Arion, Vladimir B. B.
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RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-01-01
err7
errOAAI
errSebastiani, Jessica; Puxeddu, Michela; Nalli, Marianna; Bai, Ruoli; Altieri, Ludovica; Rovella, Paola; Gaudio, Eugenio; Trisciuoglio, Daniela; Spriano, Filippo; Lavia, Patrizia; Fionda, Cinzia; Masci, Domiziana; Urbani, Andrea; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Bertoni, Francesco; Silvestri, Romano; La Regina, Giuseppe
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Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-12-01
err33
PREAI
errBarreca, Marilia; Span, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne -Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai, Ruoli; Steinmetz, Michel O.; Prota, Andrea E.; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola
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Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-11-17
err15
errOAAI
errPuxeddu, Michela; Wu, Jianchao; Bai, Ruoli; D'Ambrosio, Michele; Nalli, Marianna; Coluccia, Antonio; Manetto, Simone; Ciogli, Alessia; Masci, Domiziana; Urbani, Andrea; Fionda, Cinzia; Coni, Sonia; Bordone, Rosa; Canettieri, Gianluca; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
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The interaction of spongistatin 1 with tubulin (vol 727, 109296, 2022)
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2022-11-01
err0
PREAI
errBai, Ruoli; Smith III, Amos B.; Pettit, George R.; Hamel, Ernest
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Research Directions

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Co-authors
Cooperation Journals
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H-index: 122 · Papers: 1.1K
M
Manuel Hidalgo
H-index: 105 · Papers: 1.0K
D
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H-index: 101 · Papers: 949
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