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M

Manfred Jung

university of freiburg

65H-index
466Paper Count
1.4WCitation Count
Published Papers 182
Publication Date
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Development of High-Affinity CHD1 Chromodomain Inhibitors
errJournal of Medicinal Chemistry
IF6.8
err2026-05-05
err0
errOAAI
errHolger Greschik; Florian Friedrich; Ludwig Seifert; Farnoush Mousavizadeh; Francesco Fiorentino; Johannes Walz; Lin Zhang; Jianyu Li; Emanuele Fabbrizi; Stefano Tomassi; Farhad Panahi; Niklas Papenkordt; Silas L. Wurnig; Johannes Osterroth; Anna M. Strasser; Jan Ruprecht; Aurélien F. A. Moumbock; Martin Hügle; Manuela Sum; Ling Peng; Sheng Wang; Adina A. Baniahmad; Laura Pulido-Cortés; H. Th. Marc Timmers; Ralf Flaig; Eric Metzger; Bernhard Breit; Oliver Einsle; Stefan Günther; Dante Rotili; Antonello Mai; Roland Schüle; Manfred Jung
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From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors
errAngewandte Chemie International Edition
IF16.9
err2025-10-30
err0
errOAAI
errFlorian Friedrich; Dr. Marat Meleshin; Niklas Papenkordt; Lena Gaitzsch; Isabel Prucker; Dr. Marco Borso; Jan Ruprecht; Christopher Vorreiter; Sabrina Rast; Prof. Lin Zhang; Prof. Matthias Schiedel; Prof. Wolfgang Sippl; Prof. Axel Imhof; Prof. Henning J. Jessen; Prof. Oliver Einsle; Prof. Mike Schutkowski; Prof. Manfred Jung
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Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD⁺ co-factor binding
errRSC Med. Chem.
IF3.6
err2025-08-22
err0
errOAAI
errRicky Wirawan; Matthias Frei; Anna Heider; Niklas Papenkordt; Florian Friedrich; Thomas Wein; Manfred Jung; Michael Groll; eva huber; Franz Bracher
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errSave
Molecular determinants for recognition of serotonylated chromatin
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-07-22
err0
errOAAI
errPulido-Cortes, Laura; Gielingh, Hajo; Thijssen, Vito; Liu, Minglong; Yoshisada, Ryoji; Soares, Leonardo Romao; Nizamuddin, Sheikh; Friedrich, Florian; Greschik, Holger; Peng, Ling; Honorato, Rodrigo Vargas; Jung, Manfred; Bonvin, Alexandre M. J. J.; Biniossek, Martin L.; Schuele, Roland; Jongkees, Seino; van Ingen, Hugo; Timmers, H. Th Marc
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Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity
errJournal of Medicinal Chemistry
IF6.8
err2025-06-17
err0
errOAAI
errSheng Wang; Nicolas P. F. Barthes; Sylvia Urban; Viktor I. Hazai; Sebastian O. Klein; Tabea Pappert; Paul Kümmel; Nicolas Heller; Johannes Bacher; Maximilian Staudt; Jan Ruprecht; Ling Peng; Manuela Sum; Christopher Berlin; Daad Sarraf; Pierre Regenass; Robin Warstat; Johannes Walz; Pankaj Mishra; Lin Zhang; Oliver Einsle; Stefan Günther; Bernhard Breit; Eric Metzger; Manfred Jung; Roland Schüle
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The bioactivity of atraric acid as an inducer of cellular senescence in prostate cancer cells is retained by lipophilic derivatives
errNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
IF3.1
err2025-03-01
err0
errOAAI
errBaniahmad, Adina Asara; Atri Roozbahani, Golnaz; Jung, Manfred; Baniahmad, Aria
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Identification and Characterization of Pyrimidine Nucleoside 2′-Hydroxylase
errACS CATALYSIS
IF13.1
err2025-02-13
err1
PREAI
errGenz, F; Friedrich, F; Lönarz, C; Einsle, O; Jung, M; Müller, M; Fessner, ND
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A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
errRSC CHEMICAL BIOLOGY
IF3.1
err2025-01-01
err0
errOAAI
errZmyslia, Mariia; Capper, Michael J.; Grimmeisen, Michael; Sartory, Kerstin; Deuringer, Benedikt; Abdelsalam, Mohamed; Shen, Kaiwei; Jung, Manfred; Sippl, Wolfgang; Koch, Hans-Georg; Kaul, Laurine; Suess, Regine; Koehnke, Jesko; Jessen-Trefzer, Claudia
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Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-11-11
err0
errOAAI
errBaumann, Anne; Papenkordt, Niklas; Robaa, Dina; Szigetvari, Peter D.; Vogelmann, Anja; Bracher, Franz; Sippl, Wolfgang; Jung, Manfred; Haavik, Jan
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errSave
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-07
err1
PREAI
errColcerasa, Arianna; Friedrich, Florian; Melesina, Jelena; Moser, Patrick; Vogelmann, Anja; Tzortzoglou, Pavlos; Neuwirt, Emilia; Sum, Manuela; Robaa, Dina; Zhang, Lin; Ramos-Morales, Elizabeth; Romier, Christophe; Einsle, Oliver; Metzger, Eric; Schuele, Roland; Gross, Olaf; Sippl, Wolfgang; Jung, Manfred
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Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-03-27
err1
PREAI
errXiong, Yan; Greschik, Holger; Johansson, Catrine; Seifert, Ludwig; Gamble, Vicki; Park, Kwang-su; Fagan, Vincent; Li, Fengling; Chau, Irene; Vedadi, Masoud; Arrowsmith, Cheryl H.; Brennan, Paul; Fedorov, Oleg; Jung, Manfred; Farnie, Gillian; Liu, Jing; Oppermann, Udo; Schuele, Roland; Jin, Jian
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errSave
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
errNATURE COMMUNICATIONS
IF15.7
err2024-01-02
err2
errOAAI
errWang, Sheng; Klein, Sebastian O.; Urban, Sylvia; Staudt, Maximilian; Barthes, Nicolas P. F.; Willmann, Dominica; Bacher, Johannes; Sum, Manuela; Bauer, Helena; Peng, Ling; Rennar, Georg A.; Gratzke, Christian; Schuele, Katrin M.; Zhang, Lin; Einsle, Oliver; Greschik, Holger; Macleod, Calum; Thomson, Christopher G.; Jung, Manfred; Metzger, Eric; Schuele, Roland
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Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-30
err9
errOAAI
errSinatra, Laura; Vogelmann, Anja; Friedrich, Florian; Tararina, Margarita A.; Neuwirt, Emilia; Colcerasa, Arianna; Koenig, Philipp; Toy, Lara; Yesiloglu, Talha Z.; Hilscher, Sebastian; Gaitzsch, Lena; Papenkordt, Niklas; Zhai, Shiyang; Zhang, Lin; Romier, Christophe; Einsle, Oliver; Sippl, Wolfgang; Schutkowski, Mike; Gross, Olaf; Bendas, Gerd; Christianson, David W.; Hansen, Finn K.; Jung, Manfred; Schiedel, Matthias
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A novel pan-selective bromodomain inhibitor for epigenetic drug design
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-03-01
err1
PREAI
errWarstat, Robin; Pervaiz, Mehrosh; Regenass, Pierre; Amann, Marius; Schmidtkunz, Karin; Einsle, Oliver; Jung, Manfred; Breit, Bernhard; Huegle, Martin; Guenther, Stefan
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Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics
errCHEMICAL COMMUNICATIONS
IF4.2
err2023-01-01
err2
errOAAI
errKlein, Sebastian O. O.; Baniahmad, Adina A. A.; Jung, Manfred
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errSave
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages
errCHEMMEDCHEM
IF3.4
err2022-11-08
err7
PREAI
errNoce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Haeberli, Cecile; Keiser, Jennifer; Mai, Antonello
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Frontiers in Medicinal Chemistry 2022 Goes Virtual
errCHEMMEDCHEM
IF3.4
err2022-10-05
err0
PREAI
errDiamanti, Eleonora; Mendez, Maria; Ross, Tatjana; Kuttruff, Christian A.; Lefranc, Julien; Klingler, Franca-Maria; von Nussbaum, Franz; Jung, Manfred; Gehringer, Matthias
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Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-10-01
err10
PREAI
errGlas, Carina; Naydenova, Eli; Lechner, Severin; Woessner, Nathalie; Yang, Liu; Dietschreit, Johannes C. B.; Sun, Hongyan; Jung, Manfred; Kuster, Bernhard; Ochsenfeld, Christian; Bracher, Franz
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Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni
errCHEMMEDCHEM
IF3.4
err2022-08-19
err7
PREAI
errHassan, Muhammad Murtaza; Sedighi, Abootaleb; Olaoye, Olasunkanmi O.; Haeberli, Cecile; Merz, Annika; Ramos-Morales, Elizabeth; de Araujo, Elvin D.; Romier, Christophe; Jung, Manfred; Keiser, Jennifer; Gunning, Patrick T.
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errSave
Defined stereoisomers of 2''-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2022-08-01
err1
errOAAI
errZaehringer, Sarah; Rumpf, Tobias; Melesina, Jelena; Lang, Alexander E.; Aktories, Klaus; Sippl, Wolfgang; Jung, Manfred; Wagner, Gerd K.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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C.H. Arrowsmith
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