Not logged in Effects of physical form of β-lactoglobulin and calcium ingestion on GLP-1 secretion, gastric emptying and energy intake in humans: a randomised crossover trial Watkins, Jonathan D.; Smith, Harry A.; Hengist, Aaron; Nielsen, Soren B.; Mikkelsen, Ulla Ramer; Saunders, John; Koumanov, Francoise; Betts, James A.; Gonzalez, Javier T. Share Save
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Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults Chen, Yung-Chih; Smith, Harry A.; Hengist, Aaron; Chrzanowski-Smith, Oliver J.; Mikkelsen, Ulla Ramer; Carroll, Harriet A.; Betts, James A.; Thompson, Dylan; Saunders, John; Gonzalez, Javier T. Share Save
Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor Vilums, Maris; Zweemer, Annelien J. M.; Dilanchian, Arian; van Veldhoven, Jacobus P. D.; de Vries, Henk; Brussee, Johannes; Saunders, John; Stamos, Dean; Heitman, Laura H.; IJzerman, Adriaan P. Share Save
When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists Vilums, Maris; Zweemer, Annelien J. M.; Barmare, Farhana; van der Gracht, Anouk M. F.; Bleeker, Dave C. T.; Yu, Zhiyi; de Vries, Henk; Gross, Raymond; Clemens, Jeremy; Krenitsky, Paul; Brussee, Johannes; Stamos, Dean; Saunders, John; Heitman, Laura H.; IJerman, Adriaan P. Share Save
Multiple Binding Sites for Small-Molecule Antagonists at the CC Chemokine Receptor 2 Zweemer, Annelien J. M.; Nederpelt, Indira; Vrieling, Hilde; Hafith, Sarah; Doornbos, Maarten L. J.; de Vries, Henk; Abt, Jeffrey; Gross, Raymond; Stamos, Dean; Saunders, John; Smit, Martine J.; IJzerman, Adriaan P.; Heitman, Laura H. Share Save
Structure-Kinetic Relationships-An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists Vilums, Maris; Zweemer, Annelien J. M.; Yu, Zhiyi; de Vries, Henk; Hillger, Julia M.; Wapenaar, Hannah; Bollen, Ilse A. E.; Barmare, Farhana; Gross, Raymond; Clemens, Jeremy; Krenitsky, Paul; Brussee, Johannes; Stamos, Dean; Saunders, John; Heitman, Laura H.; IJzerman, Adriaan P. Share Save
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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy Lanier, Marion C.; Moorjani, Manisha; Luo, Zhiyong; Chen, Yongsheng; Lin, Emily; Tellew, John E.; Zhang, Xiaohu; Williams, John P.; Gross, Raymond S.; Lechner, Sandra M.; Markison, Stacy; Joswig, Tanya; Kargo, William; Piercey, Jaime; Santos, Mark; Malany, Siobhan; Zhao, Marilyn; Petroski, Robert; Crespo, Maria I.; Diaz, Jose-Luis; Saunders, John; Wen, Jenny; O'Brien, Zhihong; Jalali, Kayvon; Madan, Ajay; Slee, Deborah H. Share Save
Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor Chen, Chen; Wu, Dongpei; Guo, Zhiqiang; Xie, Qiu; Reinhart, Greg J.; Madan, Ajay; Wen, Jenny; Chen, Takung; Huang, Charles Q.; Chen, Mi; Chen, Yongsheng; Tucci, Fabio C.; Rowbottom, Martin; Pontillo, Joseph; Zhu, Yun-Fei; Wade, Warren; Saunders, John; Bozigian, Haig; Struthers, R. Scott Share Save
Characterization of Thien-2-yl 1S,2R-Milnacipran Analogues as Potent Norepinephrine/Serotonin Transporter Inhibitors for the Treatment of Neuropathic Pain Dyck, Brian; Tamiya, Junko; Jovic, Florence; Pick, Rebecca R.; Bradbury, Margaret J.; O'Brien, Julie; Wen, Jenny; Johns, Michael; Madan, Ajay; Fleck, Beth A.; Foster, Alan C.; Li, Binfeng; Zhang, Mingzhu; Tran, Joe A.; Vickers, Troy; Grey, Jonathan; Saunders, John; Chen, Chen Share Save
Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease Zhang, Xiaohu; Tellew, John E.; Luo, Zhiyong; Moorjani, Manisha; Lin, Emily; Lanier, Marion C.; Chen, Yongsheng; Williams, John P.; Saunders, John; Lechner, Sandra M.; Markison, Stacy; Joswig, Tanya; Petroski, Robert; Piercey, Jaime; Kargo, William; Malany, Siobhan; Santos, Mark; Gross, Raymond S.; Wen, Jenny; Jalali, Kayvon; O'Brien, Zhihong; Stotz, Carol E.; Crespo, Maria I.; Diaz, Jose-Luis; Slee, Deborah H. Share Save
2-amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists:: 1.: Structure-activity relationships and optimization of heterocyclic substituents Slee, Deborah H.; Chen, Yongsheng; Zhang, Xiaohu; Moorjani, Manisha; Lanier, Marion C.; Lin, Emily; Rueter, Jaimie K.; Williams, John P.; Lechner, Sandra M.; Markison, Stacy; Malany, Siobhan; Santos, Mark; Gross, Raymond S.; Jalali, Kayvon; Sai, Yang; Zuo, Zhiyang; Yang, Chun; Castro-Palomino, Julio C.; Crespo, Maria I.; Prat, Maria; Gual, Silvia; Diaz, Jose-Luis; Saunders, John Share Save
2-amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists:: 2.: Reduction of hERG activity, observed species selectivity, and structure-activity relationships Slee, Deborah H.; Moorjani, Manisha; Zhang, Xiaohu; Lin, Emily; Lanier, Marion C.; Chen, Yongsheng; Rueter, Jaimie K.; Lechner, Sandra M.; Markison, Stacy; Malany, Siobhan; Joswig, Tanya; Samos, Mark; Gross, Raymond S.; Williams, John P.; Castro-Palomino, Julio C.; Crespo, Maria I.; Prat, Maria; Gual, Silvia; Diaz, Jose-Luis; Jalali, Kayvon; Sai, Yang; Zuo, Zhiyang; Yang, Chun; Wen, Jenny; O'Brien, Zhihong; Petroski, Robert; Saunders, John Share Save
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy Slee, Deborah H.; Zhang, Xiaohu; Moorjani, Manisha; Lin, Emily; Lanier, Marion C.; Chen, Yongsheng; Rueter, Jaimie K.; Lechner, Sandra M.; Markison, Stacy; Malany, Siobhan; Joswig, Tanya; Santos, Mark; Gross, Raymond S.; Williams, John P.; Castro-Palomino, Julio C.; Crespo, Maria I.; Prat, Maria; Gual, Silvia; Diaz, Jose-Luis; Wen, Jenny; O'Brien, Zhihong; Saunders, John Share Save
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Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor Tran, Joe A.; Jiang, Wanlong; Tucci, Fabio C.; Fleck, Beth A.; Wen, Jenny; Sai, Yang; Madan, Ajay; Chen, Ta Kung; Markison, Stacy; Foster, Alan C.; Hoare, Sam R.; Marks, Daniel; Harman, John; Chen, Caroline W.; Arellano, Melissa; Marinkovic, Dragan; Bozigian, Haig; Saunders, John; Chen, Chen Share Save
Discovery of 1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methyl-phenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia Chen, Chen; Jiang, Wanlong; Tucci, Fabio; Tran, Joe A.; Fleck, Beth A.; Hoare, Sam R.; Joppa, Margaret; Markison, Stacy; Wen, Jenny; Sai, Yang; Johns, Michael; Madan, Ajay; Chen, Takung; Chen, Caroline W.; Marinkovic, Dragan; Arellano, Melissa; Saunders, John; Foster, Alan C. Share Save
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity Tran, Joe A.; Tucci, Fabio C.; Jiang, Wanlong; Marinkovic, Dragan; Chen, Caroline W.; Arellano, Melissa; Markison, Stacy; Fleck, Beth A.; Wen, Jenny; White, Nicole S.; Pontillo, Joseph; Saunders, John; Marks, Daniel; Hoare, Sam R.; Madan, Ajay; Foster, Alan C.; Chen, Chen Share Save
A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties Dyck, Brian; Markison, Stacy; Zhao, Liren; Tamiya, Junko; Grey, Jonathan; Rowbottom, Martin W.; Zhang, Mingzhu; Vickers, Troy; Sorensen, Katie; Norton, Christi; Wen, Jenny; Heise, Christopher E.; Saunders, John; Conlon, Paul; Madan, Ajay; Schwarz, David; Goodfellow, Val S. Share Save
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