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Proof- of- concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid Papini, Christina; Ullah, Irfan; Ranjan, Amalendu P.; Zhang, Shuo; Wu, Qihao; Spasov, Krasimir A.; Zhang, Chunhui; Mothes, Walther; Crawford, Jason M.; Lindenbach, Brett D.; Uchil, Pradeep D.; Kumar, Priti; Jorgensen, William L.; Anderson, Karen S. Share Save
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A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening Fisher, Christine R.; Medie, Felix Mba; Luu, Rebeccah J.; Gaibler, Robert B.; Mulhern, Thomas J.; Miller, Caitlin R.; Zhang, Chelsea J.; Rubio, Logan D.; Marr, Elizabeth E.; Vijayakumar, Vidhya; Gabriel, Elizabeth P.; Quezada, Landys Lopez; Zhang, Chun-Hui; Anderson, Karen S.; Jorgensen, William L.; Alladina, Jehan W.; Medoff, Benjamin D.; Borenstein, Jeffrey T.; Gard, Ashley L. Share Save
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Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands Liosi, Maria-Elena; Ippolito, Joseph A.; Henry, Sean P.; Krimmer, Stefan G.; Newton, Ana S.; Cutrona, Kara J.; Olivarez, Rene A.; Mohanty, Jyotidarsini; Schlessinger, Joseph; Jorgensen, William L. Share Save
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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency Zhang, Chun-Hui; Spasov, Krasimir A.; Reilly, Raquel A.; Hollander, Klarissa; Stone, Elizabeth A.; Ippolito, Joseph A.; Liosi, Maria-Elena; Deshmukh, Maya G.; Tirado-Rives, Julian; Zhang, Shuo; Liang, Zhuobin; Miller, Scott J.; Isaacs, Farren; Lindenbach, Brett D.; Anderson, Karen S.; Jorgensen, William L. Share Save
Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model Beloor, Jagadish; Kudalkar, Shalley N.; Buzzelli, Gina; Yang, Fan; Mandl, Hanna K.; Rajashekar, Jyothi K.; Spasov, Krasimir A.; Jorgensen, William L.; Saltzman, W. Mark; Anderson, Karen S.; Kumar, Priti Share Save
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Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations Zhang, Chun-Hui; Stone, Elizabeth A.; Deshmukh, Maya; Ippolito, Joseph A.; Ghahremanpour, Mohammad M.; Tirado-Rives, Julian; Spasov, Krasimir A.; Zhang, Shuo; Takeo, Yuka; Kudalkar, Shalley N.; Liang, Zhuobin; Isaacs, Farren; Lindenbach, Brett; Miller, Scott J.; Anderson, Karen S.; Jorgensen, William L. Share Save
Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead Ippolito, Joseph A.; Niu, Haichan; Bertoletti, Nicole; Carter, Zachary J.; Jin, Shengyan; Spasov, Krasimir A.; Cisneros, Jose A.; Valhondo, Margarita; Cutrona, Kara J.; Anderson, Karen S.; Jorgensen, William L. Share Save
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