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Christopher J. Smedley

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15H-index
63Paper Count
1.6KCitation Count
Published Papers 18
Publication Date
Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium
err2026-06-16
err0
errOAAI
errKyong T. Fam; Pavan Kumar Chodisetti; Zifei Wang; Joshua A. Homer; Christopher J. Smedley; Seiya Kitamura; Benjamin Silva; Yijun Xiong; Althea Hansel-Harris; Matthew Holcomb; Simeon Babarinde; Adrianna M. Turner; Daria Van Tyne; Ian A. Wilson; Stefano Forli; Benjamin F. Cravatt; Donghyun Park; Dennis W. Wolan; John E. Moses; Howard C. Hang
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Structure-Activity Relationships of Highly Potent and Selective A2B Adenosine Receptor Agonists
err2025-10-01
err0
PREAI
errSmedley, Christopher J.; Awalt, Jon Kyle; Nguyen, Anh T. N.; Wang, Bing H.; Christopoulos, Arthur; Jorg, Manuela; May, Lauren T.; Scammells, Peter J.
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The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy
err2024-12-16
err1
PREAI
errKop, Joshua W.; Hua, Carol; Priebbenow, Daniel L.; Smedley, Christopher J.
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Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs
errCHEM
IF19.6
err2023-08-01
err18
errOAAI
errSun, Shoujun; Homer, Joshua A.; Smedley, Christopher J.; Cheng, Qing-Qing; Sharpless, K. Barry; Moses, John E.
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Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells
err2023-01-01
err1
errOAAI
errGialelis, Timothy L.; Wang, Zifei; Homer, Joshua A.; Yang, Wen-Hsuan; Chung, Taemoon; Hu, Qingting; Smedley, Christopher J.; Pawar, Nitin J.; Upadhyay, Nitinkumar S.; Tuveson, David A.; Lyons, Scott K.; Lukey, Michael J.; Moses, John E.
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Diversity oriented clicking delivers ?-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors br
err2022-09-07
err22
errOAAI
errCheng, Yunfei; Li, Gencheng; Smedley, Christopher J.; Giel, Marie -Claire; Kitamura, Seiya; Woehl, Jordan L.; Bianco, Giulia; Forli, Stefano; Homer, Joshua A.; Cappiello, John R.; Wolan, Dennis W.; Moses, John E.; Sharpless, K. Barry
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Accelerated SuFEx Click Chemistry For Modular Synthesis**
err2021-12-07
err82
errOAAI
errSmedley, Christopher J.; Homer, Joshua A.; Gialelis, Timothy L.; Barrow, Andrew S.; Koelln, Rebecca A.; Moses, John E.
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Aminium cation-radical catalysed selective hydration of (E)-aryl enynes
err2021-01-01
err5
errOAAI
errGiel, Marie-Claire; Barrow, Andrew S.; Smedley, Christopher J.; Lewis, William; Moses, John E.
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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs
err2020-06-04
err92
errOAAI
errSmedley, Christopher J.; Li, Gencheng; Barrow, Andrew S.; Gialelis, Timothy L.; Giel, Marie-Claire; Ottonello, Alessandra; Cheng, Yunfei; Kitamura, Seiya; Wolan, Dennis W.; Sharpless, K. Barry; Moses, John E.
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Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides
err2019-11-28
err65
PREAI
errGiel, Marie-Claire; Smedley, Christopher J.; Mackie, Emily R. R.; Guo, Taijie; Dong, Jiajia; da Costa, Tatiana P. Soares; Moses, John E.
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
err2019-09-04
err142
errOAAI
errZheng, Qinheng; Woehl, Jordan L.; Kitamura, Seiya; Santos-Martins, Diogo; Smedley, Christopher J.; Li, Gencheng; Forli, Stefano; Moses, John E.; Wolan, Dennis W.; Sharpless, K. Barry
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Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
err2019-02-27
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errOAAI
errSmedley, Christopher J.; Zheng, Qinheng; Gao, Bing; Li, Suhua; Molino, Andrew; Duivenvoorden, Hendrika M.; Parker, Belinda S.; Wilson, David J. D.; Sharpless, K. Barry; Moses, John E.
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Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site
err2018-07-13
err13
errOAAI
errSmedley, Christopher J.; Stanley, Paul A.; Qazzaz, Mohannad E.; Prota, Andrea E.; Olieric, Natacha; Collins, Hilary; Eastman, Harry; Barrow, Andrew S.; Lim, Kuan-Hon; Kam, Toh-Seok; Smith, Brian J.; Duivenvoorden, Hendrika M.; Parker, Belinda S.; Bradshaw, Tracey D.; Steinmetz, Michel O.; Moses, John E.
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1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry
err2018-01-01
err71
PREAI
errSmedley, Christopher J.; Giel, Marie-Claire; Molino, Andrew; Barrow, Andrew S.; Wilson, David J. D.; Moses, John E.
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Sulfur-Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates
err2017-07-26
err42
PREAI
errSmedley, Christopher J.; Barrow, Andrew S.; Spiteri, Christian; Giel, Marie-Claire; Sharma, Pallavi; Moses, John E.
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Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents
err2014-09-30
err32
errOAAI
errAdams, James; Anderson, Edward C.; Blackham, Emma E.; Chiu, Yin Wa Ryan; Clarke, Thomas; Eccles, Natasha; Gill, Luke A.; Haye, Joshua J.; Haywood, Harvey T.; Hoenig, Christian R.; Kausas, Marius; Le, Joelle; Russell, Hannah L.; Smedley, Christopher; Tipping, William J.; Tongue, Tom; Wood, Charlotte C.; Yeung, Jason; Rowedder, James E.; Fray, M. Jonathan; McInally, Thomas; Macdonald, Simon J. F.
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