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C

Chris Abell

University of Cambridge

72H-index
453Paper Count
2.1WCitation Count
Published Papers 200
Publication Date
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Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism
errJournal of Medicinal Chemistry
IF6.8
err2025-07-14
err0
errOAAI
errMadeline E. Kavanagh; Kirsty J. McLean; Sophie H. Gilbert; Cecilia N. Amadi; Matthew Snee; Richard B. Tunnicliffe; Kriti Arora; Helena I. M. Boshoff; Alexander Fanourakis; Maria Jose Rebollo-Lopez; Fatima Ortega; Colin W. Levy; Andrew W. Munro; David Leys; Chris Abell; Anthony G. Coyne
errShare
errSave
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-08-27
err0
errOAAI
errStockwell, Simon R.; Scott, Duncan E.; Fischer, Gerhard; Guarino, Estrella; Rooney, Timothy P. C.; Feng, Tzu-Shean; Moschetti, Tommaso; Srinivasan, Rajavel; Alza, Esther; Asteian, Alice; Dagostin, Claudio; Alcaide, Anna; Rocaboy, Mathieu; Blaszczyk, Beata; Higueruelo, Alicia; Wang, Xuelu; Rossmann, Maxim; Perrior, Trevor R.; Blundell, Tom L.; Spring, David R.; Mckenzie, Grahame; Abell, Chris; Skidmore, John; Venkitaraman, Ashok R.; Hyvonen, Marko
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errSave
A Fragment-Based Competitive 19F LB-NMR Platform For Hotspot-Directed Ligand Profiling
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-08-12
err0
errOAAI
errMccarthy, William J.; Thomas, Sherine E.; Olaleye, Tayo; Boland, Jennifer A.; Floto, R. Andres; Williams, Glyn; Blundell, Tom L.; Coyne, Anthony G.; Abell, Chris
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errSave
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target
errINTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
IF3.4
err2023-08-01
err0
errOAAI
errHowieson, Vanessa M.; Zeng, Joy; Kloehn, Joachim; Spry, Christina; Marchetti, Chiara; Lunghi, Matteo; Varesio, Emmanuel; Soper, Andrew; Coyne, Anthony G.; Abell, Chris; van Dooren, Giel G.; Saliba, Kevin J.
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errSave
Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
errCHEMMEDCHEM
IF3.4
err2023-06-06
err1
errOAAI
errKirkman, Tim; Fun Tan, Suk; Chavez-Pacheco, Sair Maximo; Hammer, Alexander; Abell, Chris; Tosin, Manuela; Coyne, Anthony G.; Dias, Marcio V. B.
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errSave
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2023-04-12
err4
errOAAI
errKatariya, Mona M.; Snee, Matthew; Tunnicliffe, Richard B.; Kavanagh, Madeline E.; Boshoff, Helena I. M.; Amadi, Cecilia N.; Levy, Colin W.; Munro, Andrew W.; Abell, Chris; Leys, David; Coyne, Anthony G.; McLean, Kirsty J.
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errSave
Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells*
errCOLLOIDS AND SURFACES B-BIOINTERFACES
IF5.6
err2023-01-01
err3
errOAAI
errLeontidou, Tina; Yu, Ziyi; Hess, Jeannine; Geisler, Katrin; Smith, Alison G.; Coyne, Anthony; Abell, Chris
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errSave
Development of potent inhibitors by fragment-linking strategies
errCHEMICAL BIOLOGY & DRUG DESIGN
IF3.3
err2022-08-16
err13
errOAAI
errBedwell, Elizabeth, V; McCarthy, William J.; Coyne, Anthony G.; Abell, Chris
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errSave
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2022-05-30
err5
errOAAI
errThomas, Sherine E.; McCarthy, William J.; El Bakali, Jamal; Brown, Karen P.; Kim, So Yeon; Blaszczyk, Michal; Mendes, Vitor; Abell, Chris; Floto, R. Andres; Coyne, Anthony G.; Blundell, Tom L.
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errSave
Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (vol 8, 2440, 2018)
errSCIENTIFIC REPORTS
IF3.9
err2022-04-21
err0
errOAAI
errAbalde-Cela, Sara; Taladriz-Blanco, Patricia; de Oliveira, Marcelo Ganzarolli; Abell, Chris
errShare
errSave
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
errSCIENTIFIC REPORTS
IF3.9
err2022-02-24
err2
errOAAI
errDouthwaite, Julie A.; Brown, Christopher A.; Ferdinand, John R.; Sharma, Rahul; Elliott, Jane; Taylor, Molly A.; Malintan, Nancy T.; Duvoisin, Hannah; Hill, Thomas; Delpuech, Oona; Orton, Alexandra L.; Pitt, Haidee; Kuenzi, Fred; Fish, Simon; Nicholls, David J.; Cuthbert, Anna; Richards, Ian; Ratcliffe, Giles; Upadhyay, Abhishek; Marklew, Abigail; Hewitt, Craig; Ross-Thriepland, Douglas; Brankin, Christopher; Chodorge, Matthieu; Browne, Gareth; Mander, Palwinder K.; DeWildt, Ruud M.; Weaver, Shane; Smee, Penny A.; van Kempen, Joost; Bartlett, Jon G.; Allen, Paula M.; Koppe, Emma L.; Ashby, Charlotte A.; Phipps, Julian D.; Mehta, Nalini; Brierley, David J.; Tew, David G.; Leveridge, Melanie, V; Baddeley, Stuart M.; Goodfellow, Ian G.; Green, Clive; Abell, Chris; Neely, Andy; Waddell, Ian; Rees, Steve; Maxwell, Patrick H.; Pangalos, Menelas N.; Howes, Rob; Clark, Roger
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errSave
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-02-01
err6
errOAAI
errFrederickson, Martyn; Selvam, Irwin R.; Evangelopoulos, Dimitrios; McLean, Kirsty J.; Katariya, Mona M.; Tunnicliffe, Richard B.; Campbell, Bethany; Kavanagh, Madeline E.; Charoensutthivarakul, Sitthivut; Blankley, Richard T.; Levy, Colin W.; de Carvalho, Luiz Pedro S.; Leys, David; Munro, Andrew W.; Coyne, Anthony G.; Abell, Chris
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errSave
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-01-26
err6
errOAAI
errAcebron-Garcia-de-Eulate, Marta; Mayol-Llinas, Joan; Holland, Matthew T. O.; Kim, So Yeon; Brown, Karen P.; Marchetti, Chiara; Hess, Jeannine; Di Pietro, Ornella; Mendes, Vitor; Abell, Chris; Floto, R. Andres; Coyne, Anthony G.; Blundell, Tom L.
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errSave
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach
errACS INFECTIOUS DISEASES
IF3.8
err2022-01-17
err10
errOAAI
errCharoensutthivarakul, Sitthivut; Thomas, Sherine E.; Curran, Amy; Brown, Karen P.; Belardinelli, Juan M.; Whitehouse, Andrew J.; Acebron-Garcia-de-Eulate, Marta; Sangan, Jaspar; Gramani, Subramanian G.; Jackson, Mary; Mendes, Vitor; Floto, R. Andres; Blundell, Tom L.; Coyne, Anthony G.; Abell, Chris
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errSave
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections
errRSC MEDICINAL CHEMISTRY
IF3.6
err2022-01-01
err3
errOAAI
errAddison, William; Frederickson, Martyn; Coyne, Anthony G.; Abell, Chris
errShare
errSave
Microdroplets confined assembly of opal composites in dynamic borate ester-based networks
errCHEMICAL ENGINEERING JOURNAL
IF13.2
err2021-12-01
err11
PREAI
errZhang, Jing; Qin, Yipeng; Pambos, Oliver J.; Zhang, Jingjing; Chen, Su; Yu, Ziyi; Abell, Chris
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errSave
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
errCELL CHEMICAL BIOLOGY
IF7.2
err2021-06-01
err32
errOAAI
errScott, Duncan E.; Francis-Newton, Nicola J.; Marsh, May E.; Coyne, Anthony G.; Fischer, Gerhard; Moschetti, Tommaso; Bayly, Andrew R.; Sharpe, Timothy D.; Haas, Kalina T.; Barber, Lorraine; Valenzano, Chiara R.; Srinivasan, Rajavel; Huggins, David J.; Lee, Miyoung; Emery, Amy; Hardwick, Bryn; Ehebauer, Matthias; Dagostin, Claudio; Esposito, Alessandro; Pellegrini, Luca; Perrior, Trevor; McKenzie, Grahame; Blundell, Tom L.; Hyvonen, Marko; Skidmore, John; Venkitaraman, Ashok R.; Abell, Chris
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errSave
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-L-cysteine Synthetase (CoaB) Activity
errACS INFECTIOUS DISEASES
IF3.8
err2021-05-03
err5
errOAAI
errEvans, Joanna C.; Murugesan, Dinakaran; Post, John M.; Mendes, Vitor; Wang, Zhe; Nahiyaan, Navid; Lynch, Sasha L.; Thompson, Stephen; Green, Simon R.; Ray, Peter C.; Hess, Jeannine; Spry, Christina; Coyne, Anthony G.; Abell, Chris; Boshoff, Helena I. M.; Wyatt, Paul G.; Rhee, Kyu Y.; Blundell, Tom L.; Barry, Clifton E. I. I. I. I. I. I.; Mizrahi, Valerie
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errSave
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site
errNATURE COMMUNICATIONS
IF15.7
err2021-01-08
err11
errOAAI
errMendes, Vitor; Green, Simon R.; Evans, Joanna C.; Hess, Jeannine; Blaszczyk, Michal; Spry, Christina; Bryant, Owain; Cory-Wright, James; Chan, Daniel S-H; Torres, Pedro H. M.; Wang, Zhe; Nahiyaan, Navid; O'Neill, Sandra; Damerow, Sebastian; Post, John; Bayliss, Tracy; Lynch, Sasha L.; Coyne, Anthony G.; Ray, Peter C.; Abell, Chris; Rhee, Kyu Y.; Boshoff, Helena I. M.; Barry, Clifton E., III; Mizrahi, Valerie; Wyatt, Paul G.; Blundell, Tom L.
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Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (vol 63, pg 4749, 2020)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-07-22
err0
errOAAI
errSabbah, Mohamad; Mendes, Vitor; Vistal, Robert G.; Dias, David M. G.; Zahorszka, Monika; Mikusova, Katarina; Kordulakova, Jana; Coyne, Anthony G.; Blundell, Tom L.; Abell, Chris
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
C
Carol V. Robinson
H-index: 132 · Papers: 818
D
David E. Neal
H-index: 123 · Papers: 1.3K
S
Shankar Balasubramanian
H-index: 118 · Papers: 521
C
Clifton E. Barry
H-index: 113 · Papers: 448
T
Tom L. Blundell
H-index: 112 · Papers: 736
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