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Michael D. Wyatt

University of South Carolina

37H-index
141Paper Count
8.1KCitation Count
Published Papers 53
Publication Date
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Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real-World Data
errClinical and Translational Science
IF2.8
err2026-05-27
err0
errOAAI
errJoseph Magagnoli; Tammy H. Cummings; Michael D. Wyatt; Campbell McInnes; Jayakrishna Ambati; S. Scott Sutton
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Evaluating methylphenidate as a potential treatment for cocaine use disorder: a propensity score-matched study
errAmerican Journal of Drug and Alcohol Abuse
IF2.6
err2026-02-01
err0
PREAI
errMagagnoli, Joseph; Cummings, Tammy H.; Wyatt, Michael D.; Shtutman, Michael; Sutton, S. Scott
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AI-based mining of biomedical literature: Applications for drug repurposing for the treatment of dementia
errArtificial Intelligence in Medicine
IF6.2
err2025-07-10
err0
errOAAI
errAliaksandra Sikirzhytskaya; Ilya Tyagin; S. Scott Sutton; Michael D. Wyatt; Ilya Safro; Michael Shtutman
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Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery
errCANCER GENE THERAPY
IF5
err2025-05-16
err0
errOAAI
errDanda Chapagai; Klaus Strebhardt; Michael D. Wyatt; Campbell McInnes
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Semi-Synthesis of Dimeric Cannabidiol Derivatives and Evaluation of their Affinity at Neurological Targets
errJOURNAL OF NATURAL PRODUCTS
IF3.6
err2025-01-24
err0
PREAI
errStryker, Zachary; Castillo-Arellano, Jorge I.; Cutler, Stephen J.; Wyatt, Michael D.; Leon, Francisco
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errSave
Exposure to angiotensin-converting enzyme inhibitors that cross the blood-brain barrier and the risk of dementia among people with HIV
errAIDS
IF3.1
err2024-09-09
err0
PREAI
errCummings, Tammy H.; Magagnoli, Joseph; Sikirzhytskaya, Aliaksandra; Tyagin, Ilya; Safro, Ilya; Wyatt, Michael D.; Shtutman, Michael S.; Sutton, S. Scott
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errSave
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-04-03
err0
PREAI
errCastillo-Arellano, Jorge I.; Stryker, Zachary; Wyatt, Michael D.; Leon, Francisco
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Probing monomer - dimer and conformational transitions of PLK1 using catalytic and polo-box domain inhibitors
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSanhaji, Mourad; Raab, Monika; Merhej, George; Rao, Chintada Nageswara; Babic, Ivan; Nurmemmedov, Elmar; Strebhardt, Klaus; Wyatt, MIchael; McInnes, Campbell
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Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors
errACS CHEMICAL BIOLOGY
IF3.8
err2023-07-11
err7
PREAI
errChapagai, Danda; Merhej, George; McInnes, Campbell; Wyatt, Michael D.
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Development of abbapolin inhibitors of the PLK1 PBD as potential therapeutics for prostate and other challenging cancers
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errStafford, Jessy; Chapagai, Danda; Merhej, George; Pressley, Justin; Nageswara-Rao, Chintada; Wyatt, Michael; Mcinnes, Campbell
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errSave
Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer
errEXPERT OPINION ON DRUG DISCOVERY
IF4.9
err2023-01-01
err20
errOAAI
errStafford, Jessy M.; Wyatt, Michael D.; McInnes, Campbell
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errSave
Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2022-12-01
err10
errOAAI
errGasparian, A.; Aksenova, M.; Oliver, D.; Levina, E.; Doran, R.; Lucius, M.; Piroli, G.; Oleinik, N.; Ogretmen, B.; Mythreye, K.; Frizzell, N.; Broude, E.; Wyatt, M. D.; Shtutman, M.
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errSave
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration
errNATURE COMMUNICATIONS
IF15.7
err2022-06-10
err19
errOAAI
errJhanji, Megha; Rao, Chintada Nageswara; Massey, Jacob C.; Hope, Marion C., III; Zhou, Xueyan; Keene, C. Dirk; Ma, Tao; Wyatt, Michael D.; Stewart, Jason A.; Sajish, Mathew
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Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-01-01
err9
errOAAI
errCraig, Sandra N.; Baxter, Merissa; Chapagai, Danda; Stafford, Jessy M.; Nurmemmedov, Elmar; Altomare, Diego; Wyatt, Michael D.; McInnes, Campbell
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errSave
Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-07-02
err0
errOAAI
errChapagai, Danda; Ramamoorthy, Gurusankar; Varghese, Jessy; Nurmemmedov, Elmar; McInnes, Campbell; Wyatt, Michael D.
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errSave
The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4 (vol 102, pg 151, 2018)
errINTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
IF2.8
err2021-01-01
err1
PREAI
errSiddharth, Sumit; Nayak, Anmada; Das, Sarita; Nayak, Deepika; Panda, Jyochanamayi; Wyatt, Michael D.; Kundu, Chanakya Nath
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Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2020-12-01
err20
errOAAI
errCui, B. Celia; Sikirzhytski, Vitali; Aksenova, Marina; Lucius, Matthew D.; Levon, Gabrielle H.; Mack, Zachary T.; Pollack, Charlotte; Odhiambo, Diana; Broude, Eugenia; Lizarraga, Sofia B.; Wyatt, Michael D.; Shtutman, Michael
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Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor
errCHEMMEDCHEM
IF3.4
err2020-04-28
err13
errOAAI
errBaxter, Merissa; Chapagai, Danda; Craig, Sandra; Hurtado, Cecilia; Varghese, Jessy; Nurmemmedov, Elmar; Wyatt, Michael D.; McInnes, Campbell
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errSave
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation
errJOURNAL OF NEUROIMMUNE PHARMACOLOGY
IF3.5
err2019-12-04
err17
errOAAI
errAksenova, Marina; Sybrandt, Justin; Cui, Biyun; Sikirzhytski, Vitali; Ji, Hao; Odhiambo, Diana; Lucius, Matthew D.; Turner, Jill R.; Broude, Eugenia; Pena, Edsel; Lizarraga, Sofia; Zhu, Jun; Safro, Ilya; Wyatt, Michael D.; Shtutman, Michael
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errSave
Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal
errSCIENCE ADVANCES
IF12.5
err2019-10-11
err70
errOAAI
errAdeluyi, Adewale; Guerin, Lindsey; Fisher, Miranda L.; Galloway, Ashley; Cole, Robert D.; Chan, Sherine S. L.; Wyatt, Michael D.; Davis, Shannon W.; Freeman, Linnea R.; Ortinski, Pavel I.; Turner, Jill R.
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Research Directions

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Co-authors
Cooperation Journals
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Curtis C. Harris
H-index: 137 · Papers: 1.3K
A
Anders Pape Møller
H-index: 134 · Papers: 1.1K
C
Catherine J. Murphy
H-index: 99 · Papers: 559
Y
Yibin Wang
H-index: 99 · Papers: 1.0K
C
C. Dirk Keene
H-index: 84 · Papers: 544
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