Not logged in Discovery of I-1000233, a potent, selective and brain permeable SHP2 allosteric inhibitor Puca, Francesca; Fabbrini, Danilo; Ciammaichella, Alina; Missineo, Antonino; Bisbocci, Monica; Nibbio, Martina; Di Marco, Annalise; Apicella, Claudia; Colaceci, Fabrizio; Sasso, Romina; Natale, Daniela; Scalabri, Francesco; Alli, Cristina; Pucci, Vincenzo; Montalbetti, Christian; Petrocchi, Alessia; Carugo, Alessandro; Toniatti, Carlo Share Save
Discovery of AM E3: A novel α-TLSPR monoclonal antibody for the ADC treatment of CRLF2-rearranged Ph-like B-ALL Dall'Armi, Claudia; Di Biasio, Valentina; Paolini, Chantal; Natale, Daniela; Scalabri, Francesco; Missineo, Antonino; Alaimo, Nadine; Nuzzo, Maurizio; Demartis, Anna; Di Pasquale, Pamela; Benoni, Roberto; Caretti, Fulvia; Beghetto, Elisa; Colaceci, Fabrizio; Sasso, Romina; Pucci, Vincenzo; Carugo, Alessandro; Tomei, Licia; Toniatti, Carlo Share Save
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors Torrente, Esther; Fodale, Valentina; Ciammaichella, Alina; Ferrigno, Federica; Ontoria, Jesus M.; Ponzi, Simona; Rossetti, Ilaria; Sferrazza, Alessio; Amaudrut, Jerome; Missineo, Antonino; Esposito, Simone; Palombo, Simone; Nibbio, Martina; Cerretani, Mauro; Bisbocci, Monica; Cellucci, Antonella; di Marco, Annalise; Alli, Cristina; Pucci, Vincenzo; Toniatti, Carlo; Petrocchi, Alessia Share Save
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease Colarusso, Stefania; Ferrigno, Federica; Ponzi, Simona; Pavone, Francesca; Conte, Immacolata; Abate, Luigi; Beghetto, Elisa; Missineo, Antonino; Amaudrut, Jerome; Bresciani, Alberto; Paonessa, Giacomo; Tomei, Licia; Montalbetti, Christian; Bianchi, Elisabetta; Toniatti, Carlo; Ontoria, Jesus M. M. Share Save
Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs Gallo, Mariana; Vanni, Domitilla; Esposito, Simone; Alaimo, Nadine; Orvieto, Federica; Rulli, Federica; Missineo, Antonino; Caretti, Fulvia; Bonelli, Fabio; Veneziano, Maria; Orsatti, Laura; Monteagudo, Edith Share Save
NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model Moretti, Daniele; Tambone, Sara; Cerretani, Mauro; Fezzardi, Paola; Missineo, Antonino; Sherman, Leticia-Toledo; Munoz-Sajuan, Ignacio; Harper, Steven; Dominquez, Celia; Pacifici, Robert; Tomei, Licia; Park, Larry; Bresciani, Alberto Share Save
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction Colarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Andreini, Matteo; Cerretani, Mauro; Missineo, Antonino; Moretti, Daniele; Tambone, Sara; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Munoz-Sanjuan, Ignacio; Park, Larry; Summa, Vincenzo; Tomei, Licia; Bresciani, Alberto; Dominguez, Celia; Toledo-Sherman, Leticia; Bianchi, Elisabetta Share Save
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme Turcano, Lorenzo; Battista, Theo; De Haro, Esther Torrente; Missineo, Antonino; Alli, Cristina; Paonessa, Giacomo; Colotti, Gianni; Harper, Steven; Fiorillo, Annarita; Ilari, Andrea; Bresciani, Alberto Share Save
Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening Turcano, Lorenzo; Torrente, Esther; Missineo, Antonino; Andreini, Matteo; Gramiccia, Marina; Di Muccio, Trentina; Genovese, Ilaria; Fiorillo, Annarita; Harper, Steven; Bresciani, Alberto; Colotti, Gianni; Ilari, Andrea Share Save
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1) Bresciani, Alberto; Missineo, Antonino; Gallo, Mariana; Cerretani, Mauro; Fezzardi, Paola; Tomei, Licia; Cicero, Daniel Oscar; Altamura, Sergio; Santoprete, Alessia; Ingenito, Raffaele; Bianchi, Elisabetta; Pacifici, Robert; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Harper, Steven; Toledo-Sherman, Leticia; Park, Larry C. Share Save
DEVELOPMENT OF AN NRF2-KEAP1 PROTEIN-PROTEIN DISRUPTOR FOR PROOF OF CONCEPT Bresciani, Alberto; Cerretani, Mauro; D'Amico, Melania; Fezzardi, Paola; Gallo, Mariana; Missineo, Antonino; Moretti, Daniele; Santoprete, Alessia; Tambone, Sara; Tomei, Licia; Dominguez, Celia; Sanjuan, Ignacio Munoz; Sherman, Leticia Toledo; Park, Larry Share Save
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