未登录 Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons 影响辛伐他汀和辛伐他汀酸药代动力学的内在因素：泰国成年人的年龄相关研究及跨人群比较 Srimatimanon, Thanate; Udomnilobol, Udomsak; Chariyavilaskul, Pajaree; Siwamogsatham, Sarawut; Praditpornsilpa, Kearkiat; Vorasettakarnkij, Yongkasem; Petchlorlian, Aisawan; Vanwong, Natchaya; Piriyapongsa, Jittima; Tipsombatboon, Pavita; Yodsurang, Varalee; Prueksaritanont, Thomayant 分享 收藏
Bridging Pharmacokinetics and Pharmacodynamics: A PBPK/PD Model-Based Approach for Deferasirox Dosing in Transfusion-Dependent Thalassemia 连接药代动力学与药效学：一种基于PBPK/PD模型的地拉罗司在输血依赖型地中海贫血中的给药方案 Sakares, Watchara; Udomnilobol, Udomsak; Pan, Xian; Yampayon, Kittika; Ekwattanakit, Supachai; Viprakasit, Vip; Limwongse, Chanin; Srichairatanakool, Somdet; Teerawonganan, Polsak; Kunsa-ngiem, Sumate; Khaowroongrueng, Vipada; Techatanawat, Isariya; Prueksaritanont, Thomayant; Yodsurang, Varalee 分享 收藏
Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor Ruengsatra, Tanachote; Soponpong, Jakapun; Nalinratana, Nonthaneth; Jirapongwattana, Niphat; Dunkoksung, Wilasinee; Rattanangkool, Eakkaphon; Deesiri, Sirikan; Srisa, Jakkrit; Songthammanuphap, Songkiat; Udomnilobol, Udomsak; Prueksaritanont, Thomayant 分享 收藏
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Validation of a Microdose Probe Drug Cocktail for Clinical Drug Interaction Assessments for Drug Transporters and CYP3A Prueksaritanont, T.; Tatosian, D. A.; Chu, X.; Railkar, R.; Evers, R.; Chavez-Eng, C.; Lutz, R.; Zeng, W.; Yabut, J.; Chan, G. H.; Cai, X.; Latham, A. H.; Hehman, J.; Stypinski, D.; Brejda, J.; Zhou, C.; Thornton, B.; Bateman, K. P.; Fraser, I.; Stoch, S. A. 分享 收藏
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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo Cherrin, Craig; Haskell, Kathleen; Howell, Bonnie; Jones, Raymond; Leander, Karen; Robinson, Ronald; Watkins, Aubrey; Bilodeau, Mark; Hoffman, Jacob; Sanderson, Philip; Hartman, George; Mahan, Elizabeth; Prueksantanont, Thomayant; Jiang, Guoqiang; She, Qing-Bai; Rosen, Neal; Sepp-Lorenzino, Laura; Defeo-Jones, Deborah; Huber, Hans E. 分享 收藏
Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin Prueksaritanont, Thomayant; Chu, Xiaoyan; Evers, Raymond; Klopfer, Stephanie O.; Caro, Luzelena; Kothare, Prajakti A.; Dempsey, Cynthia; Rasmussen, Scott; Houle, Robert; Chan, Grace; Cai, Xiaoxin; Valesky, Robert; Fraser, Iain P.; Stoch, S. Aubrey 分享 收藏
siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds Burke, Rob S.; Somasuntharam, Inthirai; Rearden, Paul; Brown, Duncan; Deshmukh, Sujal V.; DiPietro, Martha A.; DiMuzio, Jillian; Eisenhandler, Roy; Fauty, Scott E.; Gibson, Christopher; Gindy, Marian E.; Hamilton, Kelly A.; Knemeyer, Ian; Koeplinger, Kenneth A.; Kwon, Hae Won; Lifsted, Traci Q.; Menzel, Karsten; Patel, Mihir; Pudvah, Nicole; Rudd, Deanne Jackson; Seitzer, Jessica; Strapps, Walter R.; Prueksaritanont, Thomayant; Thompson, Charles D.; Hochman, Jerome H.; Carr, Brian A. 分享 收藏
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Discovery of 5-Chloro-N-[( 5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia Roecker, Anthony J.; Mercer, Swati P.; Schreier, John D.; Cox, Christopher D.; Fraley, Mark E.; Steen, Justin T.; Lemaire, Wei; Bruno, Joseph G.; Harrell, C. Meacham; Garson, Susan L.; Gotter, Anthony L.; Fox, Steven V.; Stevens, Joanne; Tannenbaum, Pamela L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Stellabott, Joyce; Hartman, George D.; Young, Steven D.; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J. 分享 收藏
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UGT2B17 Genetic Polymorphisms Dramatically Affect the Pharmacokinetics of MK-7246 in Healthy Subjects in a First-in-Human Study Wang, Y-H; Trucksis, M.; McElwee, J. J.; Wong, P. H.; Maciolek, C.; Thompson, C. D.; Prueksaritanont, T.; Garrett, G. C.; Declercq, R.; Vets, E.; Willson, K. J.; Smith, R. C.; Klappenbach, J. A.; Opiteck, G. J.; Tsou, J. A.; Gibson, C.; Laethem, T.; Panorchan, P.; Iwamoto, M.; Shaw, P. M.; Wagner, J. A.; Harrelson, J. C. 分享 收藏
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Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties Coleman, Paul J.; Schreier, John D.; Cox, Christopher D.; Breslin, Michael J.; Whitman, David B.; Bogusky, Michael J.; McGaughey, Georgia B.; Bednar, Rodney A.; Lemaire, Wei; Doran, Scott M.; Fox, Steven V.; Garson, Susan L.; Gotter, Anthony L.; Harrell, C. Meacham; Reiss, Duane R.; Cabalu, Tamara D.; Cui, Donghui; Prueksaritanont, Thomayant; Stevens, Joanne; Tannenbaum, Pamela L.; Ball, Richard G.; Stellabott, Joyce; Young, Steven D.; Hartman, George D.; Winrow, Christopher J.; Renger, John J. 分享 收藏
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